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While sex differences in cardiovascular disease (CVD) risk factors and outcomes are well established, the question of whether vascular contributions to AD\/ADRD vary by sex has only recently garnered attention. In this narrative review, we discuss sex differences in conventional CVD risk factors (e.g., hypertension, dyslipidemia, diabetes), as well as underrecognized female\u2010specific (e.g., menopause history, polycystic ovary syndrome, adverse pregnancy outcomes) and female\u2010predominant (e.g., autoimmune conditions, breast cancer) CVD risk factors. Despite their relevance, these sex\u2010specific considerations are rarely incorporated into current approaches to quantify CVD risk in AD\/ADRD research. We offer recommendations to address these gaps and promote the use of sex\u2010informed methods for studying cardiovascular contributions to AD\/ADRD in women, which is essential for developing precision strategies to improve outcomes for all individuals at risk of dementia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Highlights<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>There are extensive sex differences in cardiovascular risk, dementia risk, and their interrelationships.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Many cardiovascular risk factors confer greater risk for dementia in women than men.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Existing approaches to quantifying cardiovascular risk often overlook sex differences and female\u2010specific factors.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Sex\u2010informed approaches are essential for an accurate understanding of cardiovascular contributions to dementia.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec>","DOI":"10.1002\/alz.70610","type":"journal-article","created":{"date-parts":[[2025,8,25]],"date-time":"2025-08-25T07:05:47Z","timestamp":1756105547000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Cardiovascular contributions to dementia: Examining sex differences and female\u2010specific factors"],"prefix":"10.1002","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4598-0201","authenticated-orcid":false,"given":"Madeline","family":"Wood Alexander","sequence":"first","affiliation":[{"name":"Hurvitz Brain Sciences Program Sunnybrook Research Institute  Toronto Ontario Canada"},{"name":"Rehabilitation Sciences Institute Temerty Faculty of Medicine University of Toronto 500 University Ave  Toronto Ontario Canada"},{"name":"Harquail Centre for Neuromodulation Sunnybrook Health Sciences Centre University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane","family":"Paterson","sequence":"additional","affiliation":[{"name":"Hurvitz Brain Sciences Program Sunnybrook Research Institute  Toronto Ontario Canada"},{"name":"Harquail Centre for Neuromodulation Sunnybrook Health Sciences Centre University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zoe","family":"Arvanitakis","sequence":"additional","affiliation":[{"name":"Rush Alzheimer's Disease Center Rush University Medical Center  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra E.","family":"Black","sequence":"additional","affiliation":[{"name":"Hurvitz Brain Sciences Program Sunnybrook Research Institute  Toronto Ontario Canada"},{"name":"Rehabilitation Sciences Institute Temerty Faculty of Medicine University of Toronto 500 University Ave  Toronto Ontario Canada"},{"name":"Centre for Brain Resilience and Recovery Hurvitz Brain Sciences Program Sunnybrook Research Institute Toronto Ontario Canada"},{"name":"Division of Neurology Department of Medicine Sunnybrook Health Sciences Centre University of Toronto Toronto Ontario Canada"},{"name":"Rotman Research Institute Baycrest Hospital University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaitlin B.","family":"Casaletto","sequence":"additional","affiliation":[{"name":"Memory and Aging Center Department of Neurology Weill Institute for Neurosciences University of California  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie K.","family":"Christakis","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology University of Toronto  Toronto Ontario Canada"},{"name":"Department of Obstetrics &amp; Gynaecology St. Michael's Hospital  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gillian","family":"Einstein","sequence":"additional","affiliation":[{"name":"Rotman Research Institute Baycrest Hospital University of Toronto  Toronto Ontario Canada"},{"name":"Dalla Lana School of Public Health University of Toronto  Toronto Ontario Canada"},{"name":"Department of Psychology University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liisa A. 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