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post mortem<\/jats:italic>\n Alzheimer's disease (AD) studies compared to European\u2010ancestry (EA) individuals.\n <\/jats:p>\n <\/jats:sec>\n \n METHODS<\/jats:title>\n We generated transcriptome\u2010wide bulk pre\u2010frontal cortex (PFC) gene expression data from 125 AA donors with neuropathologically determined AD and 82 AA controls.<\/jats:p>\n <\/jats:sec>\n \n RESULTS<\/jats:title>\n \n Transcriptome\u2010wide significant differential expression was observed with 482 genes. The most significant,\n ADAMTS2<\/jats:italic>\n , showed 1.52 times higher expression in AD cases (\n p<\/jats:italic>\n \u00a0=\u00a02.96x10\n \u22128<\/jats:sup>\n ). Comparison of findings with those from a recent gene expression study of EA brain donors revealed substantial concordance, including\n ADAMTS2<\/jats:italic>\n . Other associations not observed in EA results may be especially relevant to AD risk in the AA population. Examination of AA AD GWAS\u2010implicated variants identified several expression quantitative trait loci.\n <\/jats:p>\n <\/jats:sec>\n \n CONCLUSION<\/jats:title>\n \n This first large\u2010scale AA brain AD gene expression study identified many differentially expressed genes, including\n ADAMTS2<\/jats:italic>\n , and supports gene expression as a molecular pathway underlying the impact of several AA AD risk variants.\n <\/jats:p>\n <\/jats:sec>\n \n Highlights<\/jats:title>\n \n \n \n We performed the largest African American brain tissue Alzheimer's disease (AD) gene expression study.<\/jats:p>\n <\/jats:list-item>\n \n \n Expression differences for 482 genes, notably\n ADAMTS2<\/jats:italic>\n , were study\u2010wide significant.\n <\/jats:p>\n <\/jats:list-item>\n \n Many significant differentially expressed genes are involved in energy metabolism.<\/jats:p>\n <\/jats:list-item>\n \n Several previously known AD\u2010associated variants in African Americans are eQTLs.<\/jats:p>\n <\/jats:list-item>\n \n These results advance knowledge of the genetic basis of AD in the AA population.<\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/alz.70629","type":"journal-article","created":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T11:00:15Z","timestamp":1759921215000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Novel differentially expressed genes and multiple biological pathways for Alzheimer's disease identified in brain tissue from African American donors"],"prefix":"10.1002","volume":"21","author":[{"given":"Mark W.","family":"Logue","sequence":"first","affiliation":[{"name":"Department of Psychiatry Boston University Chobanian & Avedisian School of Medicine Boston Massachusetts USA"},{"name":"Department of Medicine (Biomedical Genetics) Boston University Chobanian & Avedisian School of Medicine Boston Massachusetts USA"},{"name":"Department of Biostatistics and Boston University School of Public Health Boston Massachusetts USA"},{"name":"National Center for PTSD Behavioral Sciences Division VA Boston Healthcare System Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adam","family":"Labadorf","sequence":"additional","affiliation":[{"name":"Department of Neurology Boston University Chobanian & Avedisian School of Medicine Boston Massachusetts USA"},{"name":"Bioinformatics Hub Boston University Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicholas K.","family":"O'Neill","sequence":"additional","affiliation":[{"name":"Department of Medicine (Biomedical Genetics) Boston University Chobanian & Avedisian School of Medicine Boston Massachusetts USA"},{"name":"Bioinformatics Program Boston University Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dennis W.","family":"Dickson","sequence":"additional","affiliation":[{"name":"Departments of Neuroscience and Laboratory Medicine & Pathology Mayo Clinic Jacksonville Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brittany N.","family":"Dugger","sequence":"additional","affiliation":[{"name":"Departments of Pathology and Laboratory Medicine UC Davis School of Medicine Sacramento California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margaret E.","family":"Flanagan","sequence":"additional","affiliation":[{"name":"Northwestern University Feinberg School of Medicine Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew P.","family":"Frosch","sequence":"additional","affiliation":[{"name":"C.S. Kubik Laboratory for Neuropathology Massachusetts General Hospital & Harvard Medical School Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marla","family":"Gearing","sequence":"additional","affiliation":[{"name":"GADRC and Departments of Pathology & Laboratory Medicine and Neurology Emory University Atlanta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lee\u2010Way","family":"Jin","sequence":"additional","affiliation":[{"name":"Departments of Pathology and Laboratory Medicine UC Davis School of Medicine Sacramento California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia","family":"Kofler","sequence":"additional","affiliation":[{"name":"Division of Neuropathology University of Pittsburgh Pittsburgh Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Mayeux","sequence":"additional","affiliation":[{"name":"Taub Institute for Research on 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Pathology University of Southern California Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melissa E.","family":"Murray","sequence":"additional","affiliation":[{"name":"Departments of Neuroscience and Laboratory Medicine & Pathology Mayo Clinic Jacksonville Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter T.","family":"Nelson","sequence":"additional","affiliation":[{"name":"Sanders\u2010Brown Center on Aging and Department of Pathology & Laboratory Medicine University of Kentucky Lexington Kentucky USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard J.","family":"Perrin","sequence":"additional","affiliation":[{"name":"Departments of Neurology and Pathology and Immunology Washington University School of Medicine St. Louis Missouri USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie 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