{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,5]],"date-time":"2026-07-05T03:25:24Z","timestamp":1783221924332,"version":"3.54.6"},"reference-count":10,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T00:00:00Z","timestamp":1756771200000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MR\/T046171\/1"],"award-info":[{"award-number":["MR\/T046171\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007130","name":"University of Texas System","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007130","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30AG066546"],"award-info":[{"award-number":["P30AG066546"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["N\u00b0AC19\/00097"],"award-info":[{"award-number":["N\u00b0AC19\/00097"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010767","name":"Innovative Medicines Initiative","doi-asserted-by":"publisher","award":["115975"],"award-info":[{"award-number":["115975"]}],"id":[{"id":"10.13039\/501100010767","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["RA1971\/7\u20101"],"award-info":[{"award-number":["RA1971\/7\u20101"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1002\/alz.70647","type":"journal-article","created":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T04:30:14Z","timestamp":1756873814000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Replication of blood DNA methylomic signatures associated with cerebrospinal fluid levels of YKL\u201040 and NfL biomarkers"],"prefix":"10.1002","volume":"21","author":[{"given":"Timo","family":"Kaleck","sequence":"first","affiliation":[{"name":"Division of Neurogenetics and Molecular Psychiatry Department of Psychiatry and Psychotherapy Faculty of Medicine and University Hospital Cologne University of Cologne  Cologne Germany"},{"name":"Department of Old Age Psychiatry and Cognitive Disorders University Hospital Bonn  Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"Campos\u2010Martin","sequence":"additional","affiliation":[{"name":"Division of Neurogenetics and Molecular Psychiatry Department of Psychiatry and Psychotherapy Faculty of Medicine and University Hospital Cologne University of Cologne  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"Cano","sequence":"additional","affiliation":[{"name":"Ace Alzheimer Center Barcelona Universitat Internacional de Catalunya  Barcelona Spain"},{"name":"Biomedical Research Networking Centre in Neurodegenerative Diseases (CIBERNED) National Institute of Health Carlos III  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Victoria","family":"Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Ace Alzheimer Center Barcelona Universitat Internacional de Catalunya  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela","family":"Martino\u2010Adami","sequence":"additional","affiliation":[{"name":"Division of Neurogenetics and Molecular Psychiatry Department of Psychiatry and Psychotherapy Faculty of Medicine and University Hospital Cologne University of Cologne  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Kleineidam","sequence":"additional","affiliation":[{"name":"Department of Old Age Psychiatry and Cognitive Disorders University Hospital Bonn  Bonn Germany"},{"name":"German Center for Neurodegenerative Diseases (DZNE) Venusberg\u2010Campus 1  Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor M. Andrade","family":"Fuentes","sequence":"additional","affiliation":[{"name":"Division of Neurogenetics and Molecular Psychiatry Department of Psychiatry and Psychotherapy Faculty of Medicine and University Hospital Cologne University of Cologne  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kumar P.","family":"Tripathi","sequence":"additional","affiliation":[{"name":"Division of Neurogenetics and Molecular Psychiatry Department of Psychiatry and Psychotherapy Faculty of Medicine and University Hospital Cologne University of Cologne  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kayenat","family":"Parveen","sequence":"additional","affiliation":[{"name":"Division of Neurogenetics and Molecular Psychiatry Department of Psychiatry and Psychotherapy Faculty of Medicine and University Hospital Cologne University of Cologne  Cologne Germany"},{"name":"Department of Old Age Psychiatry and Cognitive Disorders University Hospital Bonn  Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel","family":"Puerta","sequence":"additional","affiliation":[{"name":"Ace Alzheimer Center Barcelona Universitat Internacional de Catalunya  Barcelona Spain"},{"name":"PhD Program in Biotechnology Faculty of Pharmacy and Food Sciences University of Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Itziar","family":"de Rojas","sequence":"additional","affiliation":[{"name":"Ace Alzheimer Center Barcelona Universitat Internacional de Catalunya  Barcelona Spain"},{"name":"Luxembourg Centre for Systems Biomedicine (LCSB) University of Luxembourg  Esch\u2010sur\u2010Alzette Luxembourg"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kishore A","family":"Ravichandran","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases (DZNE) Venusberg\u2010Campus 1  Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Peters","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases (DZNE)  Berlin Germany"},{"name":"Department of Psychiatry and Neurosciences Charit\u00e9 Universit\u00e4tsmedizin Berlin  Berlin Germany"},{"name":"ECRC Experimental and Clinical Research Center Charit\u00e9 Universit\u00e4tsmedizin Berlin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian","family":"Hellmann\u2010Regen","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases (DZNE)  Berlin Germany"},{"name":"Department of Psychiatry and Neurosciences Charit\u00e9 Universit\u00e4tsmedizin Berlin  Berlin Germany"},{"name":"ECRC Experimental and Clinical Research Center Charit\u00e9 Universit\u00e4tsmedizin Berlin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josef","family":"Priller","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases (DZNE)  Berlin Germany"},{"name":"Department of Psychiatry and Psychotherapy Charit\u00e9  Berlin Germany"},{"name":"Department of Psychiatry and Psychotherapy and German Center for Mental Health (DZPG) School of Medicine and Health Technical University of Munich  Munich Germany"},{"name":"University of Edinburgh and UK Dementia Research Institute  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Gemenetzi","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases (DZNE)  Berlin Germany"},{"name":"Department of Psychiatry and Psychotherapy Charit\u00e9  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anja","family":"Schneider","sequence":"additional","affiliation":[{"name":"Department of Old Age Psychiatry and Cognitive Disorders University Hospital Bonn  Bonn Germany"},{"name":"German Center for Neurodegenerative Diseases (DZNE) Venusberg\u2010Campus 1  Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens","family":"Wiltfang","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases (DZNE)  Goettingen Germany"},{"name":"Department of Psychiatry and Psychotherapy University Medical Center Goettingen University of Goettingen  Goettingen Germany"},{"name":"Neurosciences and Signaling Group Institute of Biomedicine (iBiMED) Department of Medical Sciences University of Aveiro Campus Universitario de Santiago  Aveiro Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emrah","family":"D\u00fczel","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases (DZNE)  Magdeburg Germany"},{"name":"Institute of Cognitive Neurology and Dementia Research (IKND) Otto\u2010von\u2010Guericke University  Magdeburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina","family":"Buerger","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases (DZNE, Munich)  Munich Germany"},{"name":"Institute for Stroke and Dementia Research (ISD) University Hospital LMU Munich  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Perneczky","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases (DZNE, Munich)  Munich Germany"},{"name":"Department of Psychiatry and Psychotherapy University Hospital LMU Munich  Munich Germany"},{"name":"Munich Cluster for Systems Neurology (SyNergy) Munich  Munich Germany"},{"name":"Ageing Epidemiology Research Unit (AGE) School of Public Health Imperial College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Teipel","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases (DZNE)  Rostock Germany"},{"name":"Department of Psychosomatic Medicine Rostock University Medical Center  Rostock Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Laske","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases (DZNE)  T\u00fcbingen Germany"},{"name":"Section for Dementia Research Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy University of T\u00fcbingen  T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederic","family":"Brosseron","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases (DZNE) Venusberg\u2010Campus 1  Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Marqui\u00e9","sequence":"additional","affiliation":[{"name":"Ace Alzheimer Center Barcelona Universitat Internacional de Catalunya  Barcelona Spain"},{"name":"Biomedical Research Networking Centre in Neurodegenerative Diseases (CIBERNED) National Institute of Health Carlos III  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel LA","family":"van den Hove","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Neuropsychology School for Mental Health and Neuroscience (MHeNs) Faculty of Health Medicine and Life Sciences (FHML) Maastricht University  Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Merc\u00e8","family":"Boada","sequence":"additional","affiliation":[{"name":"Ace Alzheimer Center Barcelona Universitat Internacional de Catalunya  Barcelona Spain"},{"name":"Biomedical Research Networking Centre in Neurodegenerative Diseases (CIBERNED) National Institute of Health Carlos III  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael T.","family":"Heneka","sequence":"additional","affiliation":[{"name":"Department of Old Age Psychiatry and Cognitive Disorders University Hospital Bonn  Bonn Germany"},{"name":"German Center for Neurodegenerative Diseases (DZNE) Venusberg\u2010Campus 1  Bonn Germany"},{"name":"Luxembourg Centre for Systems Biomedicine (LCSB) University of Luxembourg  Esch\u2010sur\u2010Alzette Luxembourg"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Wagner","sequence":"additional","affiliation":[{"name":"Department of Old Age Psychiatry and Cognitive Disorders University Hospital Bonn  Bonn Germany"},{"name":"German Center for Neurodegenerative Diseases (DZNE) Venusberg\u2010Campus 1  Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie","family":"Marchant","sequence":"additional","affiliation":[{"name":"Division of Psychiatry University College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Charles","family":"Lambert","sequence":"additional","affiliation":[{"name":"Univ. Lille, Inserm, CHU Lille Institut Pasteur de Lille LabEx DISTALZ \u2010 U1167\u2010RID\u2010AGE Facteurs de risque et d\u00e9terminants mol\u00e9culaires des maladies li\u00e9es au vieillissement  Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth","family":"Frikke\u2010Schmidt","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry Copenhagen University Hospital \u2010 Rigshospitalet  Copenhagen N Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Jessen","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases (DZNE) Venusberg\u2010Campus 1  Bonn Germany"},{"name":"Department of Psychiatry University of Cologne Medical Faculty  Cologne Germany"},{"name":"Cologne Excellence Cluster on Cellular Stress Responses in Aging\u2010Associated Diseases (CECAD) University of Cologne  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agust\u00edn","family":"Ruiz","sequence":"additional","affiliation":[{"name":"Ace Alzheimer Center Barcelona Universitat Internacional de Catalunya  Barcelona Spain"},{"name":"Biomedical Research Networking Centre in Neurodegenerative Diseases (CIBERNED) National Institute of Health Carlos III  Madrid Spain"},{"name":"Glenn Biggs Institute for Alzheimer's &amp; Neurodegenerative Diseases University of Texas Health Science Center  San Antonio Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4991-763X","authenticated-orcid":false,"given":"Alfredo","family":"Ramirez","sequence":"additional","affiliation":[{"name":"Division of Neurogenetics and Molecular Psychiatry Department of Psychiatry and Psychotherapy Faculty of Medicine and University Hospital Cologne University of Cologne  Cologne Germany"},{"name":"Department of Old Age Psychiatry and Cognitive Disorders University Hospital Bonn  Bonn Germany"},{"name":"Department of Psychiatry and Neurosciences Charit\u00e9 Universit\u00e4tsmedizin Berlin  Berlin Germany"},{"name":"Cologne Excellence Cluster on Cellular Stress Responses in Aging\u2010Associated Diseases (CECAD) University of Cologne  Cologne Germany"},{"name":"Department of Psychiatry &amp; Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases University of Texas Health Science Center  San Antonio Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,9,2]]},"reference":[{"key":"e_1_2_1_4_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.14098"},{"key":"e_1_2_1_4_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12330"},{"key":"e_1_2_1_4_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-017-0314-2"},{"key":"e_1_2_1_4_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2016.18"},{"key":"e_1_2_1_4_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bty476"},{"key":"e_1_2_1_4_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-023-02219-4"},{"key":"e_1_2_1_4_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awac024"},{"key":"e_1_2_1_4_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkv907"},{"key":"e_1_2_1_4_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-022-01024-z"},{"key":"e_1_2_1_4_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-024-02524-6"}],"container-title":["Alzheimer's &amp; Dementia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alz.70647","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/alz.70647","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alz.70647","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,15]],"date-time":"2026-02-15T11:07:58Z","timestamp":1771153678000},"score":1,"resource":{"primary":{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/10.1002\/alz.70647"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":10,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["10.1002\/alz.70647"],"URL":"https:\/\/doi.org\/10.1002\/alz.70647","archive":["Portico"],"relation":{},"ISSN":["1552-5260","1552-5279"],"issn-type":[{"value":"1552-5260","type":"print"},{"value":"1552-5279","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"2025-04-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-02","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70647"}}