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Dementia"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>The PResymptomatic EValuation of Experimental or Novel Treatments for Alzheimer's Disease (PREVENT\u2010AD) is an investigator\u2010driven study that was created in 2011 and enrolled cognitively normal older adults with a family history of sporadic AD. Participants are deeply phenotyped and have now been followed annually for more than 12 years (median follow\u2010up 8.0 years, SD 3.1). Multimodal magnetic resonance imaging (MRI), genetic, neurosensory, clinical, cerebrospinal fluid, and cognitive data collected until 2017 on 348 participants who agreed to open sharing with the neuroscience community were already available. We now share a new release including 6 years of additional follow\u2010up cognitive data, and additional MRI follow\u2010ups, clinical progression, new longitudinal behavioral and lifestyle measures (questionnaires, actigraphy), longitudinal AD plasma biomarkers, amyloid\u2010beta and tau positron emission tomography (PET), magnetoencephalography, as well as neuroimaging analytic measures from all MRI modalities. We describe the PREVENT\u2010AD study, the data shared with the global research community, as well as the model we created to sustain longitudinal follow\u2010ups while also allowing new innovative data collection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>The PResymptomatic EValuation of Experimental or Novel Treatments for Alzheimer's Disease (PREVENT\u2010AD) is a single\u2010site longitudinal study that started in 2011 with annual follow\u2010up data collection on individuals at risk of Alzheimer's disease who were all cognitively normal at enrolment.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>All 387 participants were enrolled between 2011 and 2017 and 306 (79%) of these participants were still in the study as of December 2023.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>While the PREVENT\u2010AD dataset was not originally planned to be shared with the global research community, 348 participants retrospectively consented for their data to be shared with researchers worldwide.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>The first release of data was in 2019. We now share a second release that includes 6 years of additional follow\u2010up visits, information on clinical progression and novel cognitive, behavioral, genetic, plasma and neuroimaging (amyloid and tau positron emission tomography [PET], magnetoencephalography [MEG], and new magnetic resonance imaging [MRI] sequences) data. It also includes analytic outputs for neuroimaging modalities.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.70653","type":"journal-article","created":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T11:16:19Z","timestamp":1759144579000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["The PREVENT\u2010AD cohort: Accelerating Alzheimer's disease research and treatment in Canada and beyond"],"prefix":"10.1002","volume":"21","author":[{"given":"Sylvia","family":"Villeneuve","sequence":"first","affiliation":[{"name":"StoP\u2010AD Centre Douglas Mental Health University Institute McGill University  Montr\u00e9al Quebec Canada"},{"name":"Department of Psychiatry McGill University  Montr\u00e9al Quebec Canada"},{"name":"McConnell Brain Imaging Center Montreal Neurological Institute McGill University  Montr\u00e9al Quebec Canada"},{"name":"Cerebral Imaging Centre Douglas Mental Health University Institute McGill University  Montr\u00e9al Quebec Canada"},{"name":"Integrated Program in Neuroscience McGill University  Montr\u00e9al Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judes","family":"Poirier","sequence":"additional","affiliation":[{"name":"StoP\u2010AD Centre Douglas Mental Health University Institute McGill University  Montr\u00e9al Quebec Canada"},{"name":"Department of Psychiatry McGill University  Montr\u00e9al Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John C. S.","family":"Breitner","sequence":"additional","affiliation":[{"name":"StoP\u2010AD Centre Douglas Mental Health University Institute McGill University  Montr\u00e9al Quebec Canada"},{"name":"Department of Psychiatry McGill University  Montr\u00e9al Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Tremblay\u2010Mercier","sequence":"additional","affiliation":[{"name":"StoP\u2010AD Centre Douglas Mental Health University Institute McGill University  Montr\u00e9al Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordana","family":"Remz","sequence":"additional","affiliation":[{"name":"StoP\u2010AD Centre Douglas Mental Health University Institute McGill University  Montr\u00e9al Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Michel","family":"Raoult","sequence":"additional","affiliation":[{"name":"StoP\u2010AD Centre Douglas Mental Health University Institute McGill 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