{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T09:09:01Z","timestamp":1784365741105,"version":"3.55.0"},"reference-count":87,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T00:00:00Z","timestamp":1757376000000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["20SFRN35360180"],"award-info":[{"award-number":["20SFRN35360180"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100002565","name":"Alzheimer's Drug Discovery Foundation","doi-asserted-by":"publisher","award":["RDADB\u2010202104\u20102021750"],"award-info":[{"award-number":["RDADB\u2010202104\u20102021750"]}],"id":[{"id":"10.13039\/100002565","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100021066","name":"Gates Ventures","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100021066","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["P30AG072978"],"award-info":[{"award-number":["P30AG072978"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01AG083735"],"award-info":[{"award-number":["R01AG083735"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp; Dementia"],"published-print":{"date-parts":[[2025,9]]},"abstract":"Abstract<\/jats:title>\n \n \n \n We describe the rationale, methodology, and design of the Boston University Alzheimer's Disease Research Center (BU ADRC) Clinical Core (CC). The CC characterizes a longitudinal cohort of participants with\/without brain trauma to characterize the clinical presentation, biomarker profiles, and risk factors of post\u2010traumatic Alzheimer's disease (AD) and AD\u2010related dementias (ADRD), including chronic traumatic encephalopathy (CTE). Participants complete assessments of traumatic brain injury (TBI) and repetitive head impacts (RHIs); annual Uniform Data Set (UDS) and supplementary evaluations; digital phenotyping; annual blood draw; magnetic resonance imaging (MRI) and lumbar puncture every 3 years; electroencephalogram (EEG); and amyloid and\/or tau positron emission tomography (PET) on a subset. As of 3\/2025, the CC consists of 467 participants (mean age: 65.6, 50.1% female), including 163 RHI and 302 TBI who completed a UDS 3.0 baseline visit. Common sources of RHI included football (\n n<\/jats:italic>\n \u00a0=\u00a095), soccer (\n n<\/jats:italic>\n \u00a0=\u00a026), ice hockey (\n n<\/jats:italic>\n \u00a0=\u00a017), and military service (\n n<\/jats:italic>\n \u00a0=\u00a046). Most TBIs were mild (97.7%). Eighty\u2010nine percent agreed to brain donation. The BU ADRC CC will facilitate research, education, and training on post\u2010traumatic AD\/ADRD.\n <\/jats:p>\n <\/jats:sec>\n \n Highlights<\/jats:title>\n \n \n \n The Boston University Alzheimer's Disease Research Center (ADRC) Clinical Core facilitates unique research, education, and training on Alzheimer's disease and Alzheimer's disease\u2010related dementias (AD\/ADRD) with a focus on post\u2010traumatic AD\/ADRD, including chronic traumatic encephalopathy (CTE).<\/jats:p>\n <\/jats:list-item>\n \n We summarize the rationale, mission, study design, and recent updates for the Clinical Core.<\/jats:p>\n <\/jats:list-item>\n \n As of March 2025, the Clinical Core includes a longitudinal cohort of 467 participants enriched for repetitive head impacts (\u223c1\/3) and traumatic brain injury (\u223c1\/3) exposure who span the cognitive continuum, with most having available fluid and neuroimaging biomarker data and agreeing to brain donation (89%).<\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/alz.70654","type":"journal-article","created":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T09:53:05Z","timestamp":1757411585000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Boston University Alzheimer's Disease Research Center Clinical Core: Infrastructure to facilitate research on post\u2010traumatic Alzheimer's disease and related dementias"],"prefix":"10.1002","volume":"21","author":[{"given":"Michael L.","family":"Alosco","sequence":"first","affiliation":[{"name":"Boston University Alzheimer's Disease Research Center and BU CTE Center Boston University Chobanian & Avedisian School of Medicine Boston Massachusetts USA"},{"name":"Department of Neurology Boston Medical Center Boston Massachusetts USA"},{"name":"Department of Neurology Boston University Chobanian & Avedisian School of Medicine Boston Massachusetts USA"},{"name":"Department of 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