{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T06:52:24Z","timestamp":1789627944286,"version":"build-2803163510"},"reference-count":69,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,9,18]],"date-time":"2025-09-18T00:00:00Z","timestamp":1758153600000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000957","name":"Alzheimer's Association","doi-asserted-by":"publisher","award":["AARG\u201022\u2010972229"],"award-info":[{"award-number":["AARG\u201022\u2010972229"]}],"id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003061","name":"Erasmus Medisch Centrum","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003061","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["CD23\/00096"],"award-info":[{"award-number":["CD23\/00096"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>Physical activity is linked to lower dementia risk, but its connection to Alzheimer's disease (AD) pathology remains uncertain. This study examined the relationship between objectively measured physical activity and early AD biomarkers in cognitively unimpaired adults.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      Accelerometer\u2010measured physical activity and plasma AD biomarkers (beta\u2010amyloid [A\u03b2]42\/A\u03b240, p\u2010tau217) were assessed in 242 participants (age\u00a0=\u00a063.37 [54\u201379] years) of the population\u2010based Rotterdam Study. Cortical A\u03b2 was assessed via\n                      <jats:sup>18<\/jats:sup>\n                      F\u2010florbetaben positron emission tomography (PET) 7 years later. Robust regression assessed the relationship between physical activity, plasma AD biomarkers, and A\u03b2 PET burden, while compositional analysis examined how the time\u2010use composition relates to AD outcomes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Physical activity was not associated with plasma A\u03b242\/A\u03b240, p\u2010tau217, or brain A\u03b2 burden 7 years later. Reallocating awake sedentary time to physical activity showed no association with AD biomarkers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>No relationship was identified between physical activity and AD biomarkers, suggesting physical activity might affect dementia risk through other pathways or in an earlier life phase.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>Physical activity was not associated with plasma beta\u2010amyloid (A\u03b2)42\/A\u03b240 nor p\u2010tau217.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>No association was observed between physical activity and brain A\u03b2 7 years later.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Age, sex, and apolipoprotein E \u03b54 carriership did not moderate these relationships.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Reallocating 30 minutes of sedentary time to physical activity resulted in no change in Alzheimer's disease (AD) biomarkers.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.70655","type":"journal-article","created":{"date-parts":[[2025,9,18]],"date-time":"2025-09-18T14:40:57Z","timestamp":1758206457000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Objective physical activity and Alzheimer's disease burden in the population\u2010based Rotterdam Study"],"prefix":"10.1002","volume":"21","author":[{"given":"Phuong Thuy","family":"Nguyen Ho","sequence":"first","affiliation":[{"name":"Department of Radiology and Nuclear Medicine Erasmus MC University Medical Centre  Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meike W.","family":"Vernooij","sequence":"additional","affiliation":[{"name":"Department of Radiology and Nuclear Medicine Erasmus MC University Medical Centre  Rotterdam the Netherlands"},{"name":"Department of Epidemiology Erasmus MC University Medical Centre  Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trudy","family":"Voortman","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Erasmus MC University Medical Centre  Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"Rodriguez\u2010Ayllon","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Erasmus MC University Medical Centre  Rotterdam the Netherlands"},{"name":"Biomedical Research Institute of Malaga (IBIMA Platform Bionand)  Malaga Spain"},{"name":"Prevention and Health Promotion Research Network (redIAPP) &amp; Chronicity Primary Care and Health Promotion Research Network  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5739-466X","authenticated-orcid":false,"given":"Julia","family":"Neitzel","sequence":"additional","affiliation":[{"name":"Department of Radiology and Nuclear Medicine Erasmus MC University Medical Centre  Rotterdam the Netherlands"},{"name":"Department of Epidemiology Erasmus MC University Medical Centre  Rotterdam the Netherlands"},{"name":"Department of Epidemiology Harvard T.H Chan School of 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