{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T18:24:32Z","timestamp":1787509472396,"version":"build-2736575974"},"reference-count":69,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,9,7]],"date-time":"2025-09-07T00:00:00Z","timestamp":1757203200000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>Risperidone is approved for behaviors and psychological symptoms of dementia (BPSD), despite modest efficacy and known risks. Identifying responsive symptoms, treatment modifiers, and predictors is crucial for personalized treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHOD<\/jats:title>\n                    <jats:p>\n                      A one\u2010stage individual participant data meta\u2010analysis of six randomized controlled trials (risperidone:\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a01009; placebo:\n                      <jats:italic>N<\/jats:italic>\n                      \u00a0=\u00a0712) was conducted. Mixed\u2010effects models assessed treatment effects, modifiers, and predictors, with BPSD measured via the Behavioral Pathology in Alzheimer's Disease scale.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Risperidone showed modest 8 week benefits for aggression (standardized mean difference [SMD]: \u22120.22;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001), psychosis (SMD: \u22120.23;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.001), and anxiety\/phobias (SMD: \u22120.19;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.014), but not for activity, affective, or sleep disturbances. Pharmacokinetic\/pharmacodynamic\u2010related factors (e.g., body mass index, endocrine disease, race\/ethnicity) potentially modified treatment effects. Week 2 response predicted week 8 improvement (odds ratio: 4.46;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Risperidone provided symptom\u2010specific benefits in reducing aggression, psychosis, and anxiety\/phobias. Week 2 response predicted treatment outcomes, while certain patient characteristics may modify treatment response. Further research is needed to optimize the benefit\u2013risk balance and individualize treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>Risperidone modestly reduces symptoms of psychosis, aggression, and anxiety\/phobias.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Risperidone shows no effect on activity, affective, or sleep disturbances.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Patient factors (body mass index, endocrine disease, race\/ethnicity) may affect response.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Positive response by week 2 predicts significant improvement later.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.70665","type":"journal-article","created":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T03:15:36Z","timestamp":1757301336000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Treatment modifiers and predictors of risperidone response in dementia: An individual participant data meta\u2010analysis of six randomized controlled trials"],"prefix":"10.1002","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6812-7778","authenticated-orcid":false,"given":"Hieu T.","family":"Le","sequence":"first","affiliation":[{"name":"School of Pharmacy Faculty of Medicine and Health The University of Sydney, Camperdown  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-5712-2337","authenticated-orcid":false,"given":"Edward C. 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