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Although MT dynamics and MT\u2010binding agents have been studied extensively, their potential as biomarkers in neurodegenerative diseases has received limited attention. Emerging evidence suggests that MT destabilization is one of the earliest pathological events in Alzheimer's disease, Parkinson's disease, and other related disorders. This review highlights MT dysregulation as a promising marker of early neurodegenerative changes and discusses recent advances in imaging tools, particularly positron emission tomography (PET), that enable in vivo visualization of MT dynamics. We focus on the development and application of novel MT\u2010targeting PET radiotracers, such as [\n                      <jats:sup>11<\/jats:sup>\n                      C]MPC\u20106827, which demonstrate high specificity for destabilized MTs and excellent brain uptake. To our knowledge, this is the first comprehensive review emphasizing MT alterations as a translational imaging biomarker, offering a new perspective in the early detection and monitoring of neurodegenerative diseases.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>Microtubule (MT) instability is an early and underrecognized event in neurodegenerative disease pathogenesis and may precede classical hallmarks of Alzheimer's disease pathology.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>MT dysregulation holds promise as a novel diagnostic biomarker, offering new opportunities for early detection and disease monitoring in Alzheimer's disease, Parkinson's disease, and related disorders.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>\n                            Recent advances in MT\u2010targeted positron emission tomography imaging, particularly with [\n                            <jats:sup>11<\/jats:sup>\n                            C]MPC\u20106827, enable non\u2010invasive, in vivo visualization of MT dynamics with high specificity and brain penetration.\n                          <\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Cross\u2010species validation of MT imaging, from rodent models to non\u2010human primates and humans, demonstrates strong translational potential, supporting its future clinical application.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Integration of MT imaging with established amyloid, tau, and neuroinflammation markers enhances diagnostic precision, supports early intervention strategies, and enables more personalized approaches to neurodegenerative disease care.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.70670","type":"journal-article","created":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T10:03:07Z","timestamp":1758621787000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Imaging microtubule dynamics: A new frontier in biomarker development for neurodegenerative diseases"],"prefix":"10.1002","volume":"21","author":[{"given":"Naresh","family":"Damuka","sequence":"first","affiliation":[{"name":"Department of Radiology Wake Forest School of Medicine  Winston\u2010Salem North Carolina 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