{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,15]],"date-time":"2026-02-15T12:01:05Z","timestamp":1771156865092,"version":"3.50.1"},"reference-count":46,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T00:00:00Z","timestamp":1757462400000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100020206","name":"Korea Dementia Research Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100020206","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003653","name":"Korea National Institute of Health","doi-asserted-by":"publisher","award":["2024\u2010ER1003\u201001"],"award-info":[{"award-number":["2024\u2010ER1003\u201001"]}],"id":[{"id":"10.13039\/501100003653","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF\u20102019R1A5A2027340"],"award-info":[{"award-number":["NRF\u20102019R1A5A2027340"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>We developed and validated age\u2010related amyloid beta (A\u03b2) positron emission tomography (PET) trajectories using a statistical model in cognitively unimpaired (CU) individuals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      We analyzed 849 CU Korean and 521 CU non\u2010Hispanic White (NHW) participants after propensity score matching. A\u03b2 PET trajectories were modeled using the generalized additive model for location, scale, and shape (GAMLSS) based on baseline data and validated with longitudinal data. Subgroup analyses examined apolipoprotein E (\n                      <jats:italic>APOE<\/jats:italic>\n                      ) \u03b54 and sex effects.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Age\u2010related centile curves of A\u03b2 PET Centiloid values showed stable distributions in the lower percentiles, increasing with age in the upper percentiles. NHWs exhibited steeper A\u03b2 accumulation trajectories, particularly among\n                      <jats:italic>APOE<\/jats:italic>\n                      \u03b54 carriers. Calibration with longitudinal data confirmed the reliability of this cross\u2010sectional method.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>We developed a statistical model of age\u2010related A\u03b2 PET trajectories using baseline data, validated with longitudinal data. NHWs exhibited steeper trajectories than Koreans, suggesting population\u2010specific differences in A\u03b2 accumulation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>A generalized additive model for location, scale, and shape model was applied to examine age\u2010related amyloid beta (A\u03b2) trajectories with baseline data.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Trajectories were validated using longitudinal data, confirming model reliability.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Non\u2010Hispanic Whites exhibited steeper trajectories than Koreans, especially in apolipoprotein E \u03b54 carriers.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Our approach enables scalable modeling of A\u03b2 dynamics for Alzheimer's disease prevention strategies.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Findings highlight the importance of multi\u2010ethnic research in A\u03b2 accumulation.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.70675","type":"journal-article","created":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T09:14:33Z","timestamp":1757495673000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Age\u2010related amyloid beta dynamics modeled with the generalized additive model for location, scale, and shape (GAMLSS) across diverse populations: Cross\u2010sectional trajectories and longitudinal validation"],"prefix":"10.1002","volume":"21","author":[{"given":"Sungjoo","family":"Lee","sequence":"first","affiliation":[{"name":"Alzheimer's Disease Convergence Research Center Samsung Medical Center  Seoul South Korea"},{"name":"Department of Neurology Samsung Medical Center Sungkyunkwan University School of Medicine  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min Young","family":"Chun","sequence":"additional","affiliation":[{"name":"Department of Neurology Yonsei University College of Medicine  Seoul South Korea"},{"name":"Department of Neurology Yongin Severance Hospital Yonsei University Health System  \u00a0 Gyeonggi South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyemin","family":"Jang","sequence":"additional","affiliation":[{"name":"Department of Neurology Seoul National University Hospital Seoul National University College of Medicine  Seoul South Korea"},{"name":"Department of Neurology Asan Medical Center University of Ulsan College of Medicine  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Weiner","sequence":"additional","affiliation":[{"name":"Department of Radiology and Biomedical Imaging University of California San Francisco  San Francisco California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suzanne E.","family":"Schindler","sequence":"additional","affiliation":[{"name":"Department of Neurology Washington University School of Medicine  St. Louis Missouri USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daeun","family":"Shin","sequence":"additional","affiliation":[{"name":"Alzheimer's Disease Convergence Research Center Samsung Medical Center  Seoul South Korea"},{"name":"Department of Neurology Samsung Medical Center Sungkyunkwan 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