{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T04:56:51Z","timestamp":1781931411635,"version":"3.54.5"},"reference-count":61,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T00:00:00Z","timestamp":1760659200000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["UL1\u2010TR\u2010000040"],"award-info":[{"award-number":["UL1\u2010TR\u2010000040"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["UL1\u2010TR\u2010001079"],"award-info":[{"award-number":["UL1\u2010TR\u2010001079"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["UL1\u2010TR\u2010001420"],"award-info":[{"award-number":["UL1\u2010TR\u2010001420"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["R01AG054069"],"award-info":[{"award-number":["R01AG054069"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["R01AG058969"],"award-info":[{"award-number":["R01AG058969"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["RF1AG054474"],"award-info":[{"award-number":["RF1AG054474"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["R01AG080048"],"award-info":[{"award-number":["R01AG080048"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01HL127659"],"award-info":[{"award-number":["R01HL127659"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01HL126477"],"award-info":[{"award-number":["R01HL126477"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01HL101250"],"award-info":[{"award-number":["R01HL101250"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01HL135009"],"award-info":[{"award-number":["R01HL135009"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>Arterial stiffness measured within various arterial beds may be differentially associated with neuroimaging biomarkers of dementia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>We related carotid and regional (cardio\u2010ankle vascular index [CAVI] and heart\u2010ankle pulse wave velocity [haPWV]) arterial stiffness measures to biomarkers (gray matter volume [GMV], white matter hyperintensity volume [WMHV], and fractional anisotropy [WMFA]) and amyloid positron emission tomography (PET) positivity (centiloid\u00a0&gt;\u00a012.2), controlling for covariates.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>All arterial stiffness measures were associated with higher WMHV. Lower carotid distensibility (increased mechanical stress) was positively associated with WMFA, while Young's elastic modulus and haPWV (greater stiffness) were associated with lower WMFA. Only CAVI was significantly related to amyloid PET positivity, although similar effect sizes were observed for carotid measures. No main associations were observed with GMV. Significant interactions showed men and Black and Hispanic participants had stronger associations between carotid stiffness and GMV.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>Carotid stiffness measures were associated with WM injury while regional CAVI measures were associated with amyloid positivity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>We studied differences between carotid ultrasound and regional (cardio\u2010ankle vascular index [CAVI] and heart\u2010ankle pulse wave velocity [haPWV]) measures of arterial stiffness and neuroimaging abnormalities (white matter changes and amyloid positron emission tomography [PET] positivity) in the Multi\u2010Ethnic Study of Atherosclerosis, a diverse cohort of older adults.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Carotid measures were associated with white matter injury, demonstrated usingwhite matter hyperintensity volume and white matter fractional anisotropy, and were not associated with amyloid PET positivity.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Regional measures had variable relationships with white matter injury and CAVI, and in particular, were associated with amyloid deposition.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Black and Hispanic participants had significant associations between arterial stiffness measures and brain volume that were not observed in White participants.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Men showed significant associations with carotid distensibility and white matter injury while women did not.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.70688","type":"journal-article","created":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T10:27:08Z","timestamp":1760696828000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Carotid and regional arterial stiffness and dementia\u2010related imaging biomarkers in the Multi\u2010Ethnic Study of Atherosclerosis (MESA)"],"prefix":"10.1002","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1235-5285","authenticated-orcid":false,"given":"Sheina","family":"Emrani","sequence":"first","affiliation":[{"name":"Department of Neurology Perelman Center for Advanced Medicine University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordan","family":"Tanley","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Section on Gerontology and Geriatric Medicine Wake Forest School of Medicine  Winston\u2010Salem North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher L.","family":"Schaich","sequence":"additional","affiliation":[{"name":"Department of Surgery Hypertension and Vascular Research Center Wake Forest University School of Medicine  Winston\u2010Salem North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjiv","family":"Shah","sequence":"additional","affiliation":[{"name":"Department of Cardiology Northwestern University School of Medicine  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain G.","family":"Bertoni","sequence":"additional","affiliation":[{"name":"Division of Public Health Sciences Wake Forest University School of Medicine  Winston\u2010Salem North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Korcarz","sequence":"additional","affiliation":[{"name":"Cardiovascular Division, Department of Medicine University of Wisconsin School of Medicine and Public Health  Madison Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan R.","family":"Heckbert","sequence":"additional","affiliation":[{"name":"Department of Epidemiology University of Washington School of Public Health  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamad","family":"Habes","sequence":"additional","affiliation":[{"name":"Neuroimage Analytics Laboratory and Biggs Institute Neuroimaging Core Glenn Biggs Institute for Alzheimer's &amp; Neurodegenerative Diseases University of Texas Health Science Center  San Antonio Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel N.","family":"Lockhart","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Section on Gerontology and Geriatric Medicine Wake Forest School of Medicine  Winston\u2010Salem North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julio A.","family":"Chirinos","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine Hospital of the University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingzhong","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Section on Gerontology and Geriatric Medicine Wake Forest School of Medicine  Winston\u2010Salem North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James H.","family":"Stein","sequence":"additional","affiliation":[{"name":"Cardiovascular Division, Department of Medicine University of Wisconsin School of Medicine and Public Health  Madison Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam D.","family":"Gepner","sequence":"additional","affiliation":[{"name":"Cardiovascular Division, Department of Medicine University of Wisconsin School of Medicine and Public Health  Madison Wisconsin USA"},{"name":"Department of Medicine Division of Cardiovascular Medicine William S. Middleton Memorial Veteran's Hospital  Madison Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. Nick","family":"Bryan","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilya M.","family":"Nasrallah","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 A.","family":"Luchsinger","sequence":"additional","affiliation":[{"name":"Departments of Medicine and Epidemiology Columbia University Irving Medical Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen M.","family":"Hayden","sequence":"additional","affiliation":[{"name":"Department of Social Sciences and Health Policy Division of Public Health Sciences Wake Forest School of Medicine  Winston\u2010Salem North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongmei","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Medicine Division of Cardiology Duke Molecular Physiology Institute Duke University Medical Center  Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy M.","family":"Hughes","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Section on Gerontology and Geriatric Medicine Wake Forest School of Medicine  Winston\u2010Salem North Carolina USA"},{"name":"Division of Public Health Sciences Wake Forest University School of Medicine  Winston\u2010Salem North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,17]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/STR.0b013e3182299496"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2009.27"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.3090"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2020.00005"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2019.10551"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2018.21442"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.121.18776"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40885\u2010018\u20100102\u20108"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2019.07.012"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2022.1261"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000012257"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000005259"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000435301.64776.37"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2014.186"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.118.011045"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2014.186"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2022.852173"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwf113"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehi177"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehl254"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1161\/strokeaha.113.002649"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.5551\/jat.7716"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/jch.14294"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen\u20102020\u2010038581"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000107251.49515.c2"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2008.09.014"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/clc.23020"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1161\/jaha.121.023159"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1109\/tmi.2010.2046908"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.acra.2013.09.010"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2015.11.073"},{"key":"e_1_2_9_33_1","article-title":"DeepMRSeg: a convolutional deep neural network for anatomy and abnormality segmentation on MR images","author":"Doshi J","year":"2019","journal-title":"ArXiv Prepr"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2018.02.032"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.3233\/jad\u2010220646"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2021.645342"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12429"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2014.07.003"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2018.09.001"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41398\u2010019\u20100401\u20101"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1474\u20104422(12)70191\u20106"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.3233\/jad\u2010191073"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.hyp.37.5.1236"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000128420.01881.aa"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/21.9.678"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1159\/000445214"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.122.027517"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultrasmedbio.2022.06.014"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.121.18772"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.121.18444"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000435301.64776.37"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1161\/jaha.124.039925"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1161\/jaha.112.002154"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1161\/atvbaha.120.313133"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2016.07.012"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.110.968792"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1097\/hjh.0000000000003404"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10571\u2010016\u20100334\u20107"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1097\/NEN.0b013e31823ac627"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.3233\/jad\u2010201382"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1177\/13872877251331235"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(25)03117-1"}],"container-title":["Alzheimer's &amp; Dementia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alz.70688","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T12:33:40Z","timestamp":1764160420000},"score":1,"resource":{"primary":{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/10.1002\/alz.70688"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":61,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["10.1002\/alz.70688"],"URL":"https:\/\/doi.org\/10.1002\/alz.70688","archive":["Portico"],"relation":{},"ISSN":["1552-5260","1552-5279"],"issn-type":[{"value":"1552-5260","type":"print"},{"value":"1552-5279","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"2025-04-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70688"}}