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This study assessed the effects of long\u2010term anti\u2010A\u03b2 antibodies on amyloid plaques, tau tangles, and CSF tau species to determine the relationships between them.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      A post\u2010hoc analysis of the DIAN\u2010TU\u2010001 trial (NCT01760005) examined 142 participants at risk for dominantly inherited AD randomized to solanezumab (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a050), gantenerumab (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a052), or placebo (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a040). High\u2010resolution mass spectrometry quantified CSF tau species over four years.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Phosphorylated tau (p\u2010tau) species (153, 181, 217, 231) increased early in preclinical AD but were reduced with gantenerumab\u2010mediated A\u03b2 plaque reduction. Nearly a decade later, MTBR\u2010tau243 and p\u2010tau205 increased, showing no association with A\u03b2 reduction, aligning with tau tangle pathology progression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Initially changing soluble p\u2010tau species track A\u03b2 plaque reduction, while ptau205 and MTBR\u2010243 reflect tau tangle pathology, informing different pathways of therapeutic strategies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>p\u2010tau217 and p\u2010tau231 correlate with A\u03b2\u2010PET and respond to A\u03b2\u2010plaque lowering therapies.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>A\u03b2 immunotherapy trials support a direct link between p\u2010tau changes and A\u03b2 plaques<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Gantenerumab reduces A\u03b2 plaques but does not affect tau NFT\u2010related biomarkers.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Blood\u2010based p\u2010tau217 assays may provide a non\u2010invasive tool to monitor A\u03b2 therapies.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>MTBR\u2010tau243 strongly correlates with tau PET and tracks NFT pathology progression.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Further studies are needed to validate tau biomarkers for tracking NFT\u2010targeting therapies.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.70689","type":"journal-article","created":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T10:24:32Z","timestamp":1758623072000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["The relationship of soluble tau species with Alzheimer's disease amyloid plaque removal and tau pathology"],"prefix":"10.1002","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6764-3866","authenticated-orcid":false,"given":"Eric M.","family":"McDade","sequence":"first","affiliation":[{"name":"Department of Neurology Washington University School of Medicine at St. Louis  St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas R.","family":"Barth\u00e9lemy","sequence":"additional","affiliation":[{"name":"Department of Neurology Washington University School of Medicine at St. Louis  St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoqiao","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology Washington University School of Medicine at St. Louis  St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurology Washington University School of Medicine at St. Louis  St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuchen","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Neurology Washington University School of Medicine at St. Louis  St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Gordon","sequence":"additional","affiliation":[{"name":"Department of Neurology Washington University School of Medicine at St. Louis  St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tammie L. 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