{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T20:52:40Z","timestamp":1791492760294,"version":"4.3.4"},"reference-count":81,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T00:00:00Z","timestamp":1757894400000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000957","name":"Alzheimer's Association","doi-asserted-by":"publisher","award":["AARG\u201020\u2010678884"],"award-info":[{"award-number":["AARG\u201020\u2010678884"]}],"id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>Mixed neuropathology is common in dementia, but the clinical implications for neuropsychiatric symptoms (NPSs) are not well characterized.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      In a population\u2010based\n                      <jats:italic>post mortem<\/jats:italic>\n                      study, cases with Alzheimer's disease neuropathological change (ADNC) and Lewy body disease (LBD) were identified with any comorbid neuropathology (limbic\u2010predominant age\u2010related transactive response DNA\u2010binding protein 43 encephalopathy neuropathological change (LATE\u2010NC), cerebrovascular disease, LBD, and ADNC, respectively).\n                      <jats:italic>Post mortem<\/jats:italic>\n                      interviews collected information regarding NPSs and cognition to explore associations between each co\u2010pathology and NPSs across the whole cohort, as well as in participants without dementia.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Co\u2010existing neuropathology was frequent, even among individuals without clinical dementia. In cases with ADNC, comorbid neocortical LBD pathology was associated with hallucinations, regardless of cognitive status. However, ADNC co\u2010pathology in LBD was linked to a greater NPS burden in the full cohort but not in individuals without dementia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Lewy bodies are associated with hallucinations independent of cognitive impairment, whereas ADNC co\u2010pathology may contribute to NPS only when widespread and associated with cognitive dysfunction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>Neuropathological heterogeneity is high even in clinical stages without dementia.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Neocortical but not limbic or brainstem LBD co\u2010pathology is associated with hallucinations.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>LBs are associated with hallucinations independent of cognitive status.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>ADNC co\u2010pathology is not associated with NPSs in LBD without dementia.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>LATE co\u2010pathology is associated with increased risk of dementia but not NPS.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Vascular co\u2010pathology is associated with increased risk of delusions in ADNC.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.70693","type":"journal-article","created":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T11:31:56Z","timestamp":1757935916000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Co\u2010pathology in Alzheimer's disease and Lewy body disease and its association with neuropsychiatric symptoms"],"prefix":"10.1002","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9815-3616","authenticated-orcid":false,"given":"Lucy L.","family":"Gibson","sequence":"first","affiliation":[{"name":"King's College London Centre of Healthy Brain Ageing Department of Psychological Medicine Institute of Psychiatry Psychology, and Neuroscience  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lea T.","family":"Grinberg","sequence":"additional","affiliation":[{"name":"Memory and Aging Center UCSF Weill Institute for Neurosciences University of California  San Francisco California USA"},{"name":"Department of Pathology University of California  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor R.","family":"Paes","sequence":"additional","affiliation":[{"name":"Department of Pathology University of S\u00e3o Paulo Medical School Av. 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