{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T08:03:47Z","timestamp":1788509027416,"version":"build-2803163510"},"reference-count":41,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T00:00:00Z","timestamp":1758499200000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000070","name":"National Institute of Biomedical Imaging and Bioengineering","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000070","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U24 AG067418"],"award-info":[{"award-number":["U24 AG067418"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U24 AG074855"],"award-info":[{"award-number":["U24 AG074855"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U01 AG082350"],"award-info":[{"award-number":["U01 AG082350"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K01 AG078443"],"award-info":[{"award-number":["K01 AG078443"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>Amyloid positron emission tomography (PET) scans collected by Alzheimer's Disease Research Centers (ADRCs) include site\u2010specific \u201cmixed protocols\u201d and, since 2021, standardized protocols through the Standardized, Centralized AD\/ADRD Neuroimaging initiative. We compared amyloid PET from cohorts using unstandardized versus standardized pre\u2010processing protocols.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>Across cohorts, amyloid measured in Centiloids (CLs) was derived from 18F\u2010florbetapir (FBP), 18F\u2010florbetaben (FBB), 11C\u2010Pittsburgh compound B (PIB), and 18F\u2010NAV4694 (NAV) scans using identical magnetic resonance imaging\u2013free post\u2010processing pipelines. We evaluated CL distributions across cohorts and tracers using Gaussian mixture models (GMMs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Within each tracer, GMM\u2010derived amyloid negative (A\u2013) CL distributions were similar across cohorts. PIB and NAV showed lower CL variability in the A\u2013 range than FBP and FBB.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Consistent post\u2010processing yielded comparable A\u2013 distributions within tracer across cohorts with heterogeneous pre\u2010processing protocols, supporting future ADRC PET data integration. Reduced variability in A\u2013 classes for PIB and NAV suggest that lower positivity thresholds may be appropriate.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>Alzheimer's Disease Research Center (ADRC) amyloid positron emission tomography (PET) includes unstandardized and standardized pre\u2010processing.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>With consistent post\u2010processing, amyloid\u2010negative (A\u2013) Centiloids (CLs) were similar despite variable pre\u2010processing.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>CLs from 11C\u2010Pittsburgh compound B and 18F\u2010NAV4694 were less variable than 18F\u2010florbetaben and 18F\u2010florbetapir.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Similar A\u2013 CLs across variable pre\u2010processing supports combining ADRC amyloid PET.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.70697","type":"journal-article","created":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T03:28:40Z","timestamp":1758598120000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Comparison of amyloid PET acquired through standardized and unstandardized protocols"],"prefix":"10.1002","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5996-2560","authenticated-orcid":false,"given":"Karly A.","family":"Cody","sequence":"first","affiliation":[{"name":"Department of Neurology and Neurological Sciences Stanford University  Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrzej","family":"Sokolowski","sequence":"additional","affiliation":[{"name":"Department of Neurology and Neurological Sciences Stanford University  Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucah Medina","family":"Guerra","sequence":"additional","affiliation":[{"name":"Department of Neurology and Neurological Sciences Stanford University  Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip S.","family":"Insel","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences University of California  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William J.","family":"Jagust","sequence":"additional","affiliation":[{"name":"Neuroscience Department, University of California Berkeley  Berkeley California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theresa M.","family":"Harrison","sequence":"additional","affiliation":[{"name":"Neuroscience Department, University of California Berkeley  Berkeley California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth C.","family":"Mormino","sequence":"additional","affiliation":[{"name":"Department of Neurology and Neurological Sciences Stanford University  Stanford California USA"},{"name":"Wu Tsai Neurosciences Institute Stanford University  Stanford California USA"},{"name":"Molecular Imaging Program at Stanford (MIPS) Stanford University  Stanford California 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