{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T12:00:57Z","timestamp":1780920057027,"version":"3.54.1"},"reference-count":94,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T00:00:00Z","timestamp":1759104000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["PJT173409"],"award-info":[{"award-number":["PJT173409"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>Alzheimer's disease (AD) involves progressive hippocampal dysfunction and atrophy. Obesity, common in AD patients, is a known dementia risk factor. Studying their interaction is difficult in humans due to AD's slow progression. Experimental AD models comorbid with obesity are needed for translational insights. This study examined the effects of a high\u2010carbohydrate, high\u2010fat (HCHF) diet in 12\u2010month\u2010old TgF344\u2010AD rats.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>Nontransgenic (nTg) and TgAD rats received CHOW or CHOW and HCHF diet items from 9 to 12 months of age. Hippocampal neurovascular function was assessed using pseudo continuous arterial spin labeling (pCASL)\u2010MRI during forepaw stimulation. Neuronal activity was recorded with Neuropixels probes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>CHOW\u2010fed TgAD rats showed reduced hippocampal cerebral blood flow (CBF), CBF changes spread, and neuronal power responses to somatosensory stimulation; all of these deficits were improved on the HCHF diet.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>This approach provides a sensitive, task\u2010free assay of hippocampal neurovascular coupling. The transiently improved neurovascular and electrophysiological metrics in HCHF\u2010fed TgAD rats may be a manifestation of metabolically dysregulated AD brain benefitting from increased metabolite availability.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>Pseudo\u2010continuous arterial spin labeling (pCASL) magnetic resonance imaging (MRI) \u2010based characterization of hippocampal functional hyperemia.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Hippocampal functional hyperemia is attenuated in symptomatic Alzheimer's disease (AD) pathology.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>A high\u2010carbohydrate, high\u2010fat (HCHF) diet transiently restores hippocampal functional hyperemia in symptomatic AD pathology.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.70708","type":"journal-article","created":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T09:05:22Z","timestamp":1759136722000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["High\u2010caloric intake rescues early symptomatic AD\u2010induced hippocampal neurovascular coupling deficits"],"prefix":"10.1002","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-0558-2460","authenticated-orcid":false,"given":"Dustin Loren V.","family":"Almanza","sequence":"first","affiliation":[{"name":"Physical Sciences Platform, Sunnybrook Research Institute  Toronto Canada"},{"name":"Department 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