{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T19:20:56Z","timestamp":1789154456467,"version":"build-2803163510"},"reference-count":54,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,11,16]],"date-time":"2025-11-16T00:00:00Z","timestamp":1763251200000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>Coping strategies are potentially modifiable factors that may contribute to cognitive resilience. We examined whether adaptive coping modifies the association between Alzheimer's disease (AD) pathology and cognitive decline.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      We included 99 cognitively unimpaired older adults (mean age\u00a0=\u00a075.2, 59% females) from two observational cohorts who completed coping strategy assessments. Participants underwent yearly longitudinal cognitive assessments (extended PACC) over 5.3 years on average and cross\u2010sectional A\u03b2 (PiB\u2010PET) and tau (F\n                      <jats:sup>18<\/jats:sup>\n                      \u2010Flortaucipir) neuroimaging. We used linear mixed\u2010effects models.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>More frequent use of adaptive coping was associated with better cognitive trajectories, independent of AD pathology. Further, three\u2010way interactions between tau, adaptive coping, and time indicated that individuals with elevated tau and less adaptive coping showed accelerated cognitive decline, while those with more adaptive coping maintained cognitive function.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Adaptive coping strategies may confer resilience against cognitive decline. Interventions targeting coping skills could represent promising approaches for maintaining cognition in individuals at risk for AD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>Adaptive coping associates with better cognition independent of Alzheimer's disease (AD) pathology.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Adaptive coping buffers tau\u2010related effects on cognitive trajectories.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Coping strategies may be modifiable targets for cognitive decline.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.70713","type":"journal-article","created":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T03:28:29Z","timestamp":1763350109000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Adaptive stress coping is associated with cognitive resilience in at\u2010risk cognitively unimpaired older adults"],"prefix":"10.1002","volume":"21","author":[{"given":"Eleni","family":"Palpatzis","sequence":"first","affiliation":[{"name":"Department of Neurology Brigham and Women's Hospital  Boston Massachusetts USA"},{"name":"Barcelona Institute for Global Health (ISGlobal)  Barcelona Spain"},{"name":"University of Pompeu Fabra (UPF)  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph J.","family":"Locascio","sequence":"additional","affiliation":[{"name":"Harvard Catalyst Biostatistical Consulting Group  Boston Massachusetts USA"},{"name":"Department of Neurology Massachusetts General Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phebe","family":"Palmer","sequence":"additional","affiliation":[{"name":"Department of Neurology Massachusetts General Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibai","family":"Diez","sequence":"additional","affiliation":[{"name":"Department of Radiology Massachusetts General Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Gatchel","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Massachusetts General Hospital  Boston Massachusetts USA"},{"name":"Harvard Medical School  Boston Massachusetts USA"},{"name":"McLean Hospital Harvard Medical School  Belmont Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gad A.","family":"Marshall","sequence":"additional","affiliation":[{"name":"Department of Neurology Brigham and Women's Hospital  Boston Massachusetts USA"},{"name":"Department of Neurology Massachusetts General Hospital  Boston Massachusetts USA"},{"name":"Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eider M.","family":"Arenaza\u2010Urquijo","sequence":"additional","affiliation":[{"name":"Barcelona Institute for Global Health (ISGlobal)  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9425-1059","authenticated-orcid":false,"given":"Patrizia","family":"Vannini","sequence":"additional","affiliation":[{"name":"Department of Neurology Brigham and Women's Hospital  Boston Massachusetts USA"},{"name":"Department of Neurology Massachusetts General Hospital  Boston Massachusetts USA"},{"name":"Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,16]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ALZ.046459"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMOA1202753\/SUPPL_FILE\/NEJMOA1202753_DISCLOSURES.PDF"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474\u20104422(13)70044\u20109"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.wad.0000213815.20177.19"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/S13195\u2010020\u201000609\u20102\/METRICS"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000005303"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ALZ.13844"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000008979"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ALZ.12116"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/S13195\u2010017\u20100235\u20100\/TABLES\/3"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/ARCHGENPSYCHIATRY.2011.1487"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.JAGP.2019.05.005"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1037\/0022\u20103514.50.3.571"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/0091415017720890"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.JAD.2023.05.058"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.PAID.2022.111703"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.3389\/FPSYG.2024.1420327"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/GERONB\/GBAD005"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD\u2010215712\/SUPPL_FILE\/SJ\u2010PDF\u20101\u2010ALZ\u201010.3233_JAD\u2010215712.PDF"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1080\/02699050500442956"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1371\/JOURNAL.PONE.0240146"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(21)02143\u20107"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.NEUROIMAGE.2015.03.069"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.JPSYCHIRES.2021.03.050"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.JBI.2008.08.010"},{"key":"e_1_2_7_27_1","unstructured":"COVID\u201019 State of Emergency | Mass.gov. Accessed May 6 2025.https:\/\/www.mass.gov\/info\u2010details\/covid\u201019\u2010state\u2010of\u2010emergency"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.TRCI.2017.10.004"},{"key":"e_1_2_7_29_1","unstructured":"CarverCS Brief COPE Inventory. PsycTESTS Dataset. Published online June 11 2012. doi:10.1037\/T04102\u2010000"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.2307\/2136404"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/ANA.20009"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/ANA.22333"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.JNEUMETH.2008.05.005"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/JLCR.3098"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/ANA.24546"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.JALZ.2016.08.005"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/0377\u20100427(87)90125\u20107"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02289263"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.18637\/JSS.V061.I06"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1177\/1745691613504116"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1093\/BRAIN\/AWX243"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2639"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.26881"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0730\u201011.2011"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1037\/0894\u20104105.7.3.273"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.JALZ.2018.07.219"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.NEUROPSYCHOLOGIA.2009.03.004"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.14283\/JPAD.2024.140"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/HBM.26148"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/S41398\u2010023\u201002525\u2010Z"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41398\u2010025\u201003423\u20102"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.BPSC.2022.08.005"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474\u20104422(12)70191\u20106"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD\u2010142766"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1093\/GERONB\/GBU184"}],"container-title":["Alzheimer's &amp; Dementia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alz.70713","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/alz.70713","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alz.70713","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T06:40:12Z","timestamp":1780123212000},"score":1,"resource":{"primary":{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/10.1002\/alz.70713"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":54,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["10.1002\/alz.70713"],"URL":"https:\/\/doi.org\/10.1002\/alz.70713","archive":["Portico"],"relation":{},"ISSN":["1552-5260","1552-5279"],"issn-type":[{"value":"1552-5260","type":"print"},{"value":"1552-5279","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"2025-07-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70713"}}