{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T07:03:23Z","timestamp":1789628603381,"version":"build-2803163510"},"reference-count":42,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,9,18]],"date-time":"2025-09-18T00:00:00Z","timestamp":1758153600000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82270400"],"award-info":[{"award-number":["82270400"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2023A1515010731"],"award-info":[{"award-number":["2023A1515010731"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>The risk of dementia in patients with ischemic stroke and early cardiovascular complications (i.e., stroke\u2013heart syndrome [SHS]) remains underexplored.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>Patients with first\u2010ever ischemic stroke in Hong Kong between 2005 and 2020 were included. Multivariable Fine\u2013Gray competing risk analysis was performed after 1:1 propensity score matching to evaluate the association between SHS and the risk of dementia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Of the 130,605 included patients with ischemic stroke, 12,696 (9.7%) patients developed SHS. Patients with SHS had a 19% increased risk of dementia compared to those without SHS at 1 year post\u2010stroke, driven mainly by vascular dementia. This increased risk gradually declined and became non\u2010significant after 3 years post\u2010stroke. Appropriate antithrombotic therapy and comorbidities optimization were associated with a 32% reduced dementia risk in patients with SHS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>SHS is associated with an increased risk of incident dementia. Appropriate antithrombotic therapy and comorbidities optimization post\u2010stroke may reduce this heightened risk of cognitive impairment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>Association between stroke\u2013heart syndrome (SHS) and dementia was evaluated in a population\u2010based cohort.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Development of SHS associated with a 19% increased 1 year risk of dementia.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>The increased risk of dementia gradually declined with each year of follow\u2010up.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Integrated post\u2010stroke management may reduce this heightened risk of cognitive impairment.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.70716","type":"journal-article","created":{"date-parts":[[2025,9,18]],"date-time":"2025-09-18T13:36:11Z","timestamp":1758202571000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Stroke\u2013heart syndrome and risk of incident dementia among patients with first\u2010ever ischemic stroke: A territory\u2010wide population\u2010based cohort study"],"prefix":"10.1002","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3394-6604","authenticated-orcid":false,"given":"Christopher T. W.","family":"Tsang","sequence":"first","affiliation":[{"name":"Division of Cardiology The University of Hong Kong Shen Zhen Hospital  Shenzhen China"},{"name":"Cardiology Division Department of Medicine The University of Hong Kong  Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvia E.","family":"Choi","sequence":"additional","affiliation":[{"name":"Liverpool Centre for Cardiovascular Science at University of Liverpool Liverpool John Moores University and Liverpool Heart &amp; Chest Hospital  Liverpool UK"},{"name":"Department of Cardiovascular and Metabolic Medicine Institute of Life Course and Medical Sciences University of Liverpool  Liverpool UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tommaso","family":"Bucci","sequence":"additional","affiliation":[{"name":"Liverpool Centre for Cardiovascular Science at University of Liverpool Liverpool John Moores University and Liverpool Heart &amp; Chest Hospital  Liverpool UK"},{"name":"Department of Cardiovascular and Metabolic Medicine Institute of Life Course and Medical Sciences University of Liverpool  Liverpool UK"},{"name":"Department of Clinical Internal Anesthesiological and Cardiovascular Sciences Sapienza University of Rome  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfred C. W.","family":"Lau","sequence":"additional","affiliation":[{"name":"Cardiology Division Department of Medicine The University of Hong Kong  Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing\u2010Wen","family":"Ren","sequence":"additional","affiliation":[{"name":"Division of Cardiology The University of Hong Kong Shen Zhen Hospital  Shenzhen China"},{"name":"Cardiology Division Department of Medicine The University of Hong Kong  Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia\u2010Yi","family":"Huang","sequence":"additional","affiliation":[{"name":"Division of Cardiology The University of Hong Kong Shen Zhen Hospital  Shenzhen China"},{"name":"Cardiology Division Department of Medicine The University of Hong Kong  Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei\u2010Zhen","family":"Wu","sequence":"additional","affiliation":[{"name":"Division of Cardiology The University of Hong Kong Shen Zhen Hospital  Shenzhen China"},{"name":"Cardiology Division Department of Medicine The University of Hong Kong  Hong Kong China"},{"name":"Department of Geriatrics National Key Clinical Specialty Guangzhou First People's Hospital School of Medicine South China University of Technology  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen\u2010Li","family":"Gu","sequence":"additional","affiliation":[{"name":"Division of Cardiology The University of Hong Kong Shen Zhen Hospital  Shenzhen China"},{"name":"Cardiology Division Department of Medicine The University of Hong Kong  Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ran","family":"Guo","sequence":"additional","affiliation":[{"name":"Division of Cardiology The University of Hong Kong Shen Zhen Hospital  Shenzhen China"},{"name":"Cardiology Division Department of Medicine The University of Hong Kong  Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing\u2010Nan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Division of Cardiology The University of Hong Kong Shen Zhen Hospital  Shenzhen China"},{"name":"Cardiology Division Department of Medicine The University of Hong Kong  Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuen\u2010Ching","family":"Ng","sequence":"additional","affiliation":[{"name":"Cardiology Division Department of Medicine The University of Hong Kong  Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin J. 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