{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T15:11:47Z","timestamp":1790867507089,"version":"4.1.0"},"reference-count":45,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T00:00:00Z","timestamp":1759190400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100017510","name":"UK Dementia Research Institute","doi-asserted-by":"publisher","award":["UKDRI\u20101003"],"award-info":[{"award-number":["UKDRI\u20101003"]}],"id":[{"id":"10.13039\/501100017510","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>Plasma biomarkers offer promise for improving the diagnosis of Alzheimer's disease (AD) and differentiating AD and other neurodegenerative disorders (NDs) like frontotemporal dementia (FTD) from primary psychiatric disorders (PPDs), particularly in younger patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      In this prospective study, we investigated plasma phosphorylated tau 217 (p\u2010tau217), neurofilament light chain (NfL), and glial fibrillary acidic protein (GFAP) in 341 unselected participants from a neuropsychiatry memory clinic, including AD (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a040), behavioral variant FTD (bvFTD) (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a015), PPD (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a069), other NDs, and controls.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Plasma p\u2010tau217 showed strong diagnostic performance for distinguishing AD from bvFTD (96% accuracy) and PPD (93% accuracy). NfL best distinguished all NDs from PPD, while GFAP did not bring additional value. Biomarker profiles using predefined cut\u2010offs and age\u2010adjusted z\u2010scores further clarified group differences.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Plasma p\u2010tau217 and NfL have strong diagnostic utility in real\u2010world, diagnostically complex cohorts. These findings support implementation of scalable blood\u2010based biomarkers to improve early and accurate diagnosis in memory clinical settings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>Plasma p\u2010tau217 was significantly elevated in AD compared to other disorders.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>P\u2010tau217 distinguished AD from bvFTD with high accuracy.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>P\u2010tau217 distinguished AD from PPDs with high accuracy.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>NfL\/p\u2010tau217 ratio and GFAP added limited diagnostic value compared to p\u2010tau217 and NfL.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Findings support blood biomarkers in younger, real\u2010world clinical cohorts.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.70717","type":"journal-article","created":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T09:58:38Z","timestamp":1759226318000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Plasma p\u2010tau217, NfL, GFAP diagnostic performance and biomarker profiles in Alzheimer's disease, frontotemporal dementia, and psychiatric disorders, in a prospective unselected neuropsychiatry memory clinic"],"prefix":"10.1002","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3226-7645","authenticated-orcid":false,"given":"Dhamidhu","family":"Eratne","sequence":"first","affiliation":[{"name":"Neuropsychiatry Centre Royal Melbourne Hospital  Melbourne Victoria Australia"},{"name":"Department of Psychiatry University of Melbourne  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Kang","sequence":"additional","affiliation":[{"name":"Neuropsychiatry Centre Royal Melbourne Hospital  Melbourne Victoria Australia"},{"name":"Department of Psychiatry University of Melbourne  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles B","family":"Malpas","sequence":"additional","affiliation":[{"name":"Department of Medicine (Royal Melbourne Hospital) University of Melbourne  Melbourne Victoria Australia"},{"name":"Melbourne School of Psychological Sciences University of Melbourne  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christa","family":"Dang","sequence":"additional","affiliation":[{"name":"National Ageing Research Institute  Melbourne Victoria Australia"},{"name":"Department of General Practice University of Melbourne Victoria  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Courtney","family":"Lewis","sequence":"additional","affiliation":[{"name":"Institute of Health and Wellbeing Federation University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4412-7009","authenticated-orcid":false,"given":"Oneil G","family":"Bhalala","sequence":"additional","affiliation":[{"name":"Department of Medicine Royal Melbourne Hospital  Melbourne Victoria Australia"},{"name":"Genetics and Gene Regulation Division The Walter and Eliza Hall Institute of Medical Research  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiao\u2010Xin","family":"Li","sequence":"additional","affiliation":[{"name":"National Dementia Diagnostics Laboratory The Florey  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Collins","sequence":"additional","affiliation":[{"name":"National Dementia Diagnostics Laboratory The Florey  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin L","family":"Masters","sequence":"additional","affiliation":[{"name":"National Dementia Diagnostics Laboratory The Florey  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha M","family":"Loi","sequence":"additional","affiliation":[{"name":"Neuropsychiatry Centre Royal Melbourne Hospital  Melbourne Victoria Australia"},{"name":"Department of Psychiatry University of Melbourne  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9717-0820","authenticated-orcid":false,"given":"Alexander F","family":"Santillo","sequence":"additional","affiliation":[{"name":"Clinical Memory Research Unit Department of Clinical Sciences Faculty of Medicine Lund University  Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1890-4193","authenticated-orcid":false,"given":"Kaj","family":"Blennow","sequence":"additional","affiliation":[{"name":"Institute. of Neuroscience and Physiology University of Gothenburg  M\u00f6lndal Sweden"},{"name":"Clinical Neurochemistry Laboratory Sahlgrenska University Hospital  M\u00f6lndal Sweden"},{"name":"Neurodegenerative Disorder Research Center Division of Life Sciences and Medicine and Department of Neurology Institute on Aging and Brain Disorders University of Science and Technology of China and First Affiliated Hospital of USTC  Hefei Anhui P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3930-4354","authenticated-orcid":false,"given":"Henrik","family":"Zetterberg","sequence":"additional","affiliation":[{"name":"Clinical Neurochemistry Laboratory Sahlgrenska University Hospital  M\u00f6lndal Sweden"},{"name":"Department of Psychiatry and Neurochemistry Institute of Neuroscience and Physiology the Sahlgrenska Academy at the University of Gothenburg  M\u00f6lndal Sweden"},{"name":"Department of Pathology and Laboratory Medicine University of Wisconsin School of Medicine and Public Health University of Wisconsin\u2010Madison  Madison Wisconsin USA"},{"name":"Wisconsin Alzheimer's Disease Research Center University of Wisconsin School of Medicine and Public Health University of Wisconsin\u2010Madison  Madison Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis","family":"Velakoulis","sequence":"additional","affiliation":[{"name":"Neuropsychiatry Centre Royal Melbourne Hospital  Melbourne Victoria Australia"},{"name":"Department of Psychiatry University of Melbourne  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"And The MiND Study 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