{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T16:18:18Z","timestamp":1790957898133,"version":"4.1.0"},"reference-count":57,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T00:00:00Z","timestamp":1759881600000},"content-version":"am","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T00:00:00Z","timestamp":1759881600000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["PJT\u2010159711"],"award-info":[{"award-number":["PJT\u2010159711"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["446881"],"award-info":[{"award-number":["446881"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["RGPIN\u20102017\u201006962"],"award-info":[{"award-number":["RGPIN\u20102017\u201006962"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000957","name":"Alzheimer's Association","doi-asserted-by":"publisher","award":["2018\u2010AARGD\u2010591676"],"award-info":[{"award-number":["2018\u2010AARGD\u2010591676"]}],"id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000957","name":"Alzheimer's Association","doi-asserted-by":"publisher","award":["24AARF\u20101242638"],"award-info":[{"award-number":["24AARF\u20101242638"]}],"id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005825","name":"National Institute of Food and Agriculture","doi-asserted-by":"publisher","award":["project #1008787"],"award-info":[{"award-number":["project #1008787"]}],"id":[{"id":"10.13039\/100005825","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000064","name":"Banting and Best Diabetes Centre, University of Toronto","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000064","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006312","name":"BrightFocus Foundation","doi-asserted-by":"publisher","award":["A2024012F"],"award-info":[{"award-number":["A2024012F"]}],"id":[{"id":"10.13039\/100006312","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>Type 2 diabetes mellitus (T2DM) is a risk factor for dementia and cerebral small vessel disease, but there remains a need to identify targetable molecular pathways involved in the underlying pathophysiology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>In participants with Alzheimer's disease, related dementias, or cerebrovascular diseases, we assessed associations between ratios of unesterified linoleic acid (LA)\u2010derived soluble epoxide hydrolase (sEH) metabolites (diols) and substrates (epoxides), with imaging\u2010derived white matter hyperintensities (WMHs), brain parenchymal fraction (BPF), and cognitive performance. Potential moderation effects by glycemic control (hemoglobin A1c [HbA1c]) were examined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      With elevated HbA1c, greater LA\u2010derived diol\/epoxide ratios were associated with greater WMH volume (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u00a0[95% CI] =\u00a00.565 [0.100, 1.030],\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.017), lower global BPF (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u00a0[95% CI] =\u00a0\u22120.476 [\u22120.903, \u22120.048],\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.029), and poorer memory performance (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u00a0[95% CI] =\u00a0\u22120.603 [\u22121.070, \u22120.136],\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.012), such that detrimental associations were observed only in T2DM.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Cytochrome P450\u2010sEH metabolites may indicate a novel metabolic\u2010vascular contribution to dementia in individuals with T2DM.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CLINICAL TRIALS REGISTRATION INFORMATION<\/jats:title>\n                    <jats:p>ClinicalTrials.gov Identifier NCT04104373.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>LA\u2010derived sEH metabolite (diol) to substrate (epoxide) ratio was lower in individuals with diabetes.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>The diol\/epoxide ratio with high HbA1c contributed to SVD and brain atrophy.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>The CYP450\u2010sEH pathway may link metabolic and vascular contributions to dementia.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>sEH may be a potential therapeutic target in individuals with diabetes.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.70718","type":"journal-article","created":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T10:02:56Z","timestamp":1759917776000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Metabolic and vascular contributions to dementia: Soluble epoxide hydrolase\u2010derived linoleic acid oxylipins and glycemic status are related to cerebral small vessel disease markers, atrophy, and cognitive performance"],"prefix":"10.1002","volume":"21","author":[{"given":"Si Won","family":"Ryoo","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Toxicology University of Toronto  Toronto Ontario Canada"},{"name":"Hurvitz Brain Sciences Program Sunnybrook Research Institute  Toronto Ontario Canada"},{"name":"KITE Research Institute Toronto Rehabilitation Institute \u2010 University Health Network  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William Z.","family":"Lin","sequence":"additional","affiliation":[{"name":"Hurvitz Brain Sciences Program Sunnybrook Research Institute  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Magliocco","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myuri","family":"Ruthirakuhan","sequence":"additional","affiliation":[{"name":"Hurvitz Brain Sciences Program Sunnybrook Research Institute  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuen Yan","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology University of Toronto  Toronto Ontario Canada"},{"name":"Hurvitz Brain Sciences Program Sunnybrook Research Institute  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofia E.","family":"Perfetto","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology University of Toronto  Toronto Ontario Canada"},{"name":"Hurvitz Brain Sciences Program Sunnybrook Research Institute  Toronto Ontario Canada"},{"name":"KITE Research Institute Toronto Rehabilitation Institute \u2010 University Health Network  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celine","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology University of Toronto  Toronto Ontario Canada"},{"name":"Hurvitz Brain Sciences Program Sunnybrook Research Institute  Toronto Ontario Canada"},{"name":"KITE Research Institute Toronto Rehabilitation Institute \u2010 University Health Network  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natasha Z.","family":"Anita","sequence":"additional","affiliation":[{"name":"Department of Neurosciences University of California San Diego  San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen R.","family":"Arnott","sequence":"additional","affiliation":[{"name":"Indoc Systems  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony E.","family":"Lang","sequence":"additional","affiliation":[{"name":"Division of Neurology Temerty Faculty of Medicine University of Toronto  Toronto Ontario Canada"},{"name":"Tanz Centre for Research in Neurodegenerative Disease University of Toronto  Toronto Ontario Canada"},{"name":"Krembil Research Institute University Health Network  Toronto Ontario Canada"},{"name":"Edmond J. Safra Program in Parkinson's Disease Toronto Western Hospital University Health Network  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean","family":"Symons","sequence":"additional","affiliation":[{"name":"Hurvitz Brain Sciences Program Sunnybrook Research Institute  Toronto Ontario Canada"},{"name":"Department of Medical Imaging Temerty Faculty of Medicine University of Toronto  Toronto Ontario Canada"},{"name":"Department of Medical Imaging Sunnybrook Health Sciences Centre  Toronto Ontario Canada"},{"name":"Physical Sciences Platform Sunnybrook Research Institute  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert A.","family":"Hegele","sequence":"additional","affiliation":[{"name":"Robarts Research Institute Schulich School of Medicine &amp; Dentistry Western University  London Ontario Canada"},{"name":"Division of Endocrinology and Metabolism Department of Medicine Schulich School of Medicine &amp; Dentistry Western University  London Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maged","family":"Goubran","sequence":"additional","affiliation":[{"name":"Hurvitz Brain Sciences Program Sunnybrook Research Institute  Toronto Ontario Canada"},{"name":"Physical Sciences Platform Sunnybrook Research Institute  Toronto Ontario Canada"},{"name":"Department of Medical Biophysics Temerty Faculty of Medicine University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel","family":"Ramirez","sequence":"additional","affiliation":[{"name":"Hurvitz Brain Sciences Program Sunnybrook Research Institute  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Ottoy","sequence":"additional","affiliation":[{"name":"Hurvitz Brain Sciences Program Sunnybrook Research Institute  Toronto Ontario Canada"},{"name":"Division of Neurology Temerty Faculty of Medicine University of Toronto  Toronto Ontario Canada"},{"name":"Physical Sciences Platform Sunnybrook Research Institute  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer S.","family":"Rabin","sequence":"additional","affiliation":[{"name":"Hurvitz Brain Sciences Program Sunnybrook Research Institute  Toronto Ontario Canada"},{"name":"Division of Neurology Temerty Faculty of Medicine University of Toronto  Toronto Ontario Canada"},{"name":"Harquail Centre for Neuromodulation Sunnybrook Research Institute  Toronto Ontario Canada"},{"name":"Rehabilitation Sciences Institute Temerty Faculty of Medicine University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradley J.","family":"MacIntosh","sequence":"additional","affiliation":[{"name":"Hurvitz Brain Sciences Program Sunnybrook Research Institute  Toronto Ontario Canada"},{"name":"Physical Sciences Platform Sunnybrook Research Institute  Toronto Ontario Canada"},{"name":"Department of Medical Biophysics Temerty Faculty of Medicine University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krista L.","family":"Lanct\u00f4t","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology University of Toronto  Toronto Ontario Canada"},{"name":"Hurvitz Brain Sciences Program Sunnybrook Research Institute  Toronto Ontario Canada"},{"name":"KITE Research Institute Toronto Rehabilitation Institute \u2010 University Health Network  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuanyi","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Food Science and Technology College of Agriculture and Environmental Sciences University of California Davis  Davis California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugo","family":"Cogo\u2010Moreira","sequence":"additional","affiliation":[{"name":"Department of Education, ICT and Learning \u00d8stfold University College  Halden Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ameer Y.","family":"Taha","sequence":"additional","affiliation":[{"name":"Department of Food Science and Technology College of Agriculture and Environmental Sciences University of California Davis  Davis California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0030-8908","authenticated-orcid":false,"given":"Walter","family":"Swardfager","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology University of Toronto  Toronto Ontario Canada"},{"name":"Hurvitz Brain Sciences Program Sunnybrook Research Institute  Toronto Ontario Canada"},{"name":"KITE Research Institute Toronto Rehabilitation Institute \u2010 University Health Network  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the ONDRI Investigators","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,8]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.2337\/ds16\u20100041"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdi.12087"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2020.595962"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000007654"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/978\u20103\u2010030\u201050621\u20106_5"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.plefa.2018.04.006"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2020.108484"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/07315724.2003.10719328"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1006\/taap.2001.9131"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jlr.2023.100395"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12975\u2010018\u20100672\u20105"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.122.026901"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD\u2010191197"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1017\/cjn.2016.415"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac901282n"},{"key":"e_1_2_8_17_1","unstructured":"LazarC BurgerT.imputeLCMD: A Collection of Methods for Left\u2010Censored Missing Data Imputation.2022"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.26197"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000237236.88823.47"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2020.00847"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1177\/070674371405901206"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.PSYCHRES.2017.02.056"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2021.105149"},{"key":"e_1_2_8_24_1","volume-title":"R: A Language and Environment for Statistical Computing","author":"R Core Team","year":"2021"},{"key":"e_1_2_8_25_1","doi-asserted-by":"crossref","unstructured":"LongJA.interactions: Comprehensive User\u2010Friendly Toolkit for Probing Interactions.Version R package version 1.1.0;2019","DOI":"10.32614\/CRAN.package.interactions"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc24\u2010S002"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.2133\/dmpk.24.438"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.3390\/metabo12111007"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M115.677351"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/7825804"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/jpen.1451"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.108.537704"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11357\u2010025\u201001550\u20108"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnana.2020.00017"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0137323"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.14081"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2023.107273"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD\u2010220795"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.31887\/DCNS.2013.15.4\/hjahn"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/aww008"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12750"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000004983"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2017.12.006"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000201116"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2021.11.005"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1422590112"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prostaglandins.2014.09.003"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/NATURE25013"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.JAD.2020.03.070"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2023.06.002"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.plefa.2008.09.003"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.plefa.2016.05.004"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/lipd.12122"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00242.2024"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2022.104236"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2023.110896"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978\u20100\u201012\u2010385061\u20104.00002\u20107"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22094993"}],"container-title":["Alzheimer's &amp; Dementia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alz.70718","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alz.70718","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T12:33:11Z","timestamp":1764160391000},"score":1,"resource":{"primary":{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/10.1002\/alz.70718"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":57,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["10.1002\/alz.70718"],"URL":"https:\/\/doi.org\/10.1002\/alz.70718","archive":["Portico"],"relation":{},"ISSN":["1552-5260","1552-5279"],"issn-type":[{"value":"1552-5260","type":"print"},{"value":"1552-5279","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"2025-06-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-25","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70718"}}