{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T05:50:53Z","timestamp":1787637053763,"version":"build-2736575974"},"reference-count":55,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T00:00:00Z","timestamp":1758672000000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>Racial\/ethnic and sex\/gender differences in neuroimaging markers of dementia have been previously explored, but rarely with an intersectional approach.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>Using data from the Health and Aging Brain Study\u2013Health Disparities cohort, we examined neuroimaging markers of dementia using both interaction between race\/ethnicity and sex\/gender and effect modification of race\/ethnicity by sex\/gender.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>We analyzed data from 3433 dementia\u2010free participants with either magnetic resonance imaging or positron emission tomography (PET) data at baseline (mean [standard deviation] age: 65 [9] years, 36% non\u2010Hispanic White [NHW], 27% Black, 37% Hispanic, and 63% women). Compared to NHW, Black men had lower global amyloid PET standardized uptake value ratio (SUVR; \u03b2 [95% confidence interval]: \u20130.32 [\u20130.53, \u20130.11]), and Hispanic (0.65 [0.39, 0.91]) and Black women had greater medial temporal lobe tau SUVR (0.49 [0.30, 0.69]).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>We observed that the distribution of neuroimaging markers of dementia differed across racial\/ethnicity groups by sex\/gender. An intersectional approach can aid in tailoring research and clinical efforts in preventing and treating dementia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>Hispanic and Black women had greater medial temporal lobe tau deposition, compared to their non\u2010Hispanic White counterparts.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Black men had lower global amyloid deposition compared to non\u2010Hispanic White men.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Black men and women had higher burden of cerebral small vessel disease compared to their non\u2010Hispanic White counterparts, with stronger associations in Black men.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.70733","type":"journal-article","created":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T09:27:43Z","timestamp":1758706063000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Neuroimaging markers of dementia across race\/ethnicity and sex\/gender using an intersectional approach within the HABS\u2010HD cohort"],"prefix":"10.1002","volume":"21","author":[{"given":"Michelle R.","family":"Caunca","sequence":"first","affiliation":[{"name":"Department of Neurology University of California San Francisco  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amber","family":"Bahorik","sequence":"additional","affiliation":[{"name":"Department of 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