{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T12:34:31Z","timestamp":1764160471875,"version":"3.46.0"},"reference-count":36,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T00:00:00Z","timestamp":1759190400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["P30 AG072976","P30 AG10133","R01 AG19771","K01 AG049050","R01 AG061788","R01 AG057739","U19 AG024904","R01 LM013463","R01 AG068193","R01 AG092591","T32 AG071444","U01 AG068057","U01 AG072177","U19 AG074879","U24 AG074855","K07AG076659"],"award-info":[{"award-number":["P30 AG072976","P30 AG10133","R01 AG19771","K01 AG049050","R01 AG061788","R01 AG057739","U19 AG024904","R01 LM013463","R01 AG068193","R01 AG092591","T32 AG071444","U01 AG068057","U01 AG072177","U19 AG074879","U24 AG074855","K07AG076659"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>The Cognitive Change Index (CCI) is a brief questionnaire that assesses self and informant perceptions regarding cognitive function. We examined the ability of the CCI to distinguish between cognitively unimpaired (CU) older adults and those with mild cognitive impairment (MCI) or Alzheimer's disease (AD) dementia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>485 individuals from the Indiana Alzheimer's Disease Research Center (IADRC) and their study partners completed 20\u2010item self and informant versions of the CCI. Receiver operator characteristic (ROC) curves were analyzed to assess differentiation between CU and those with impairment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>High area under the ROC curve (AUC) values were obtained when using the self and informant CCI forms to distinguish CU individuals from those with impairment, with AUC values of 0.803 (95% confidence interval [CI]\u00a0=\u00a00.761\u20130.844) and 0.914 (95% CI\u00a0=\u00a00.886\u20130.942) for the self and informant forms, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>The CCI can serve as a useful screening instrument in the context of a multimodal assessment strategy for MCI and dementia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>Novel research that uses the Cognitive Change Index (CCI) for dementia screening.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Our findings suggest that CCI can distinguish those with dementia compared to those without.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>These findings can be correlated to other screening instruments.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Results could see the CCI play a role in early Alzheimer's disease (AD) screening and diagnosis.<\/jats:p>\n                        <\/jats:list-item>\n                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