{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T18:37:08Z","timestamp":1789756628468,"version":"4.0.1"},"reference-count":35,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,11,16]],"date-time":"2025-11-16T00:00:00Z","timestamp":1763251200000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["P30AG066511"],"award-info":[{"award-number":["P30AG066511"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>The precuneus and posterior cingulate\u2014key regions in early Alzheimer's disease (AD)\u2014undergo atrophy before clinical symptoms emerge. Limited research in sub\u2010Saharan Africa (SSA) has explored how blood\u2010based biomarkers relate to brain changes and cognition. This study examined these associations in older adults with dementia in Kinshasa, Democratic Republic of Congo (DRC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>A total of 117 adults (\u2265 65 years; five dementia, and 58 controls) completed neuropsychological testing and blood draws, with 75 completing neuroimaging. Plasma amyloid\u2010beta (A\u03b2) 40, A\u03b242, pTau181, pTau217, and neurofilament light chain (NfL) were analyzed using single molecule array (Simoa). Regional volumes were obtained via Freesurfer. Linear models assessed biomarker, volume, and cognitive associations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Lower A\u03b242\/40 and higher NfL levels were associated with reduced posterior cingulate and right precuneus volumes. Posterior cingulate atrophy correlated with poorer semantic fluency, memory, and executive function. Male sex and higher education were linked to larger volumes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>Plasma A\u03b242\/40 and NfL are promising biomarkers of AD\u2010related brain atrophy in SSA. Results support region\u2010specific screening approaches in global dementia research.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>First biomarker\u2010neuroimaging study of dementia in sub\u2010Saharan Africa (SSA).<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Lower amyloid\u2010beta (A\u03b2) 42\/40 linked to reduced posterior cingulate volumes.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Higher plasma NfL associated with right precuneus and PCC atrophy.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Posterior cingulate atrophy predicted memory and executive dysfunction.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Study supports plasma biomarkers for AD screening in SSA settings.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.70768","type":"journal-article","created":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T03:19:48Z","timestamp":1763349588000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Not just the medial temporal lobe: Precuneus and posterior cingulate volumes relate to plasma biomarkers and cognition in a sub\u2010Saharan African cohort"],"prefix":"10.1002","volume":"21","author":[{"given":"Maria","family":"Misiura","sequence":"first","affiliation":[{"name":"Department of Psychology Georgia State University  Atlanta Georgia USA"},{"name":"Tri\u2010Institutional Center for Translational Research in Neuroimaging &amp; Data Science Georgia State University Georgia Institute of Technology Emory University  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandria","family":"Bartlett","sequence":"additional","affiliation":[{"name":"Department of Psychology Georgia State University  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cadence","family":"Claar\u2010Pressley","sequence":"additional","affiliation":[{"name":"Neuroscience Institute Georgia State University  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennalyn","family":"Burnette","sequence":"additional","affiliation":[{"name":"Department of Psychology Georgia State University  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chinkuli","family":"Munkombwe","sequence":"additional","affiliation":[{"name":"Department of Anthropology Georgia State University  Atlanta Georgia USA"},{"name":"Women's Gender and Sexuality Studies Institute Georgia State\u00a0University  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"Ikanga","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine Emory University School of Medicine  Atlanta Georgia USA"},{"name":"Department of Psychiatry School of Medicine University of Kinshasa and Catholic University of Congo  Kinshasa Democratic Republic of the Congo"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,16]]},"reference":[{"key":"e_1_2_10_2_1","volume-title":"Dementia","author":"World Health Organization","year":"2023"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.55544\/jrasb.2.4.8"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13859"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2018.00304"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0105784"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2017.00097"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-024-12674-w"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines10010169"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11011-022-01114-1"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awad330"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-170242"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.18356\/9789213589526"},{"key":"e_1_2_10_14_1","article-title":"Dementia in sub\u2010Saharan Africa: challenges and opportunities","author":"Guerchet M","year":"2017","journal-title":"Alzheimer's Dis Int"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1101\/2024.08.06.24311577"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12756"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/1099-1166(200006)15:6<521::AID-GPS182>3.0.CO;2-F"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2010-101185"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2012.01.021"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-024-01477-w"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2018.00304"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-020-00923-z"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-021-00802-x"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2020.117270"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2025.1552348"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31826c1b9d"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-017-4768-1"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1177\/13872877241289790"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0317303"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40035-020-0186-4"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.14051"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awaa342"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-021-01563-9"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-231251"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.64.10.1489"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000007767"}],"container-title":["Alzheimer's &amp; 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