{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T19:54:11Z","timestamp":1790798051402,"version":"4.1.0"},"reference-count":54,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T00:00:00Z","timestamp":1762819200000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>Dementia is a growing public health challenge in low\u2010 and middle\u2010income countries (LMICs) like Egypt, where data are scarce. The Egyptian Dementia Network (EDN) registry addresses this gap by capturing epidemiological, clinical, and environmental data across Egypt.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>In this multicenter study, 662 participants from six governorates were enrolled using standardized tools.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>The cohort had advanced age (mean 68.3 years), low education (65.9% illiterate), and high comorbidities including hypertension (55%) and diabetes (23%). Alzheimer's disease (62%) and vascular dementia (23%) predominated. Only 24.4% received pharmacological treatment and 2.1% psychosocial support, highlighting care gaps. Household insecticide exposure (20.4%) was notable.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>EDN demonstrates the feasibility of implementing a national dementia registry in LMICs, generating baseline insights into demographic, clinical, and environmental risks. In addition, registry\u2010linked biosamples have enabled pilot multi\u2011omics and exposome analyses, underscoring its potential as a scalable scientific platform for future dementia research.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>Established Egypt's first national, multicenter dementia registry.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Aimed to characterize dementia profiles and care gaps across diverse regions.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Identified late\u2010stage diagnosis and limited access to dementia interventions.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Uncovered unique environmental risk factors relevant to the Egyptian context.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Provides a foundation for policy, research, and improved dementia care in Egypt.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.70770","type":"journal-article","created":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T11:22:49Z","timestamp":1762860169000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The Egyptian Dementia Network (EDN): Baseline characteristics from the first dementia registry in an African Arab country"],"prefix":"10.1002","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0798-1863","authenticated-orcid":false,"given":"Shimaa A.","family":"Heikal","sequence":"first","affiliation":[{"name":"Institute of Global Health and Human Ecology The American University in Cairo  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gharib","family":"Fawi","sequence":"additional","affiliation":[{"name":"Neurology Department Faculty of Medicine Sohag University  Sohag Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eman M.","family":"Khedr","sequence":"additional","affiliation":[{"name":"Neuropsychiatry Department Assiut University  Assiut Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mai","family":"Othman","sequence":"additional","affiliation":[{"name":"Institute of Global Health and Human Ecology The American University in Cairo  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara A.","family":"Moustafa","sequence":"additional","affiliation":[{"name":"Institute of Global Health and Human Ecology The American University in Cairo  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nesma G.","family":"Elsheikh","sequence":"additional","affiliation":[{"name":"Geriatric Medicine Department Faculty of Medicine Ain Shams University  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heba M.","family":"Tawfik","sequence":"additional","affiliation":[{"name":"Geriatric Medicine Department Faculty of Medicine Ain Shams University  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Elfarrash","sequence":"additional","affiliation":[{"name":"Medical Physiology Department Faculty of Medicine Mansoura University, and Medical Experimental Research Centre (MERC)  Mansoura 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