{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T21:25:45Z","timestamp":1791062745425,"version":"4.1.0"},"reference-count":67,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T00:00:00Z","timestamp":1759881600000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AG062758"],"award-info":[{"award-number":["R01AG062758"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AG0597940"],"award-info":[{"award-number":["R01AG0597940"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["P01 AG019724"],"award-info":[{"award-number":["P01 AG019724"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["U01 AG045390"],"award-info":[{"award-number":["U01 AG045390"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>Distinguishing behavioral variant frontotemporal dementia (bvFTD) from primary psychiatric disorders (PPDs) remains challenging due to overlapping clinical presentation. Neurofilament light chain (NfL) is a biomarker of neuronal damage that is elevated in neurodegenerative diseases. This study assessed the effectiveness of NfL and atrophy in differentiating bvFTD from PPDs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>Atrophy maps from frontotemporal regions were generated for 55 patients with autopsy\u2010confirmed frontotemporal lobar degeneration (bvFTD\u2010FTLD), 24 mood disorder patients, and eight bvFTD patients later determined to be non\u2010neurodegenerative (bvFTD\u2010nonND). Logistic regression was employed to assess the discriminatory abilities of atrophy and NfL levels between bvFTD\u2010FTLD and PPD (Mood Disorders + bvFTD\u2010nonND).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Both atrophy (AUC\u00a0=\u00a00.87, 95% confidence interval [95% CI:\u00a0 0.79 to 0.94]) and NfL (AUC\u00a0=\u00a00.89, 95% CI:\u00a00.81 to 0.96) showed significant predictive ability, which improved when combined (AUC\u00a0=\u00a00.93, 95% CI:\u00a0 0.87 to 0.99). Misclassification occurred mostly in low atrophy pathological subtypes and PPD with borderline NfL and frontotemporal volume.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>Combining NfL with atrophy enhances differentiation, but additional markers are needed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>Atrophy and NfL had comparable effectiveness in differentiating bvFTD from PPD.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Combining NfL and frontotemporal atrophy significantly improved predictive accuracy.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>NfL, in addition to atrophy, may be beneficial in screening for neurodegeneration in ambiguous cases.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.70771","type":"journal-article","created":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T03:16:37Z","timestamp":1759979797000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Combining plasma neurofilament light chain and frontotemporal atrophy improves differentiation of bvFTD from primary psychiatric disorders"],"prefix":"10.1002","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8636-0864","authenticated-orcid":false,"given":"Sean","family":"Coulborn","sequence":"first","affiliation":[{"name":"Memory and Aging Center, Department of Neurology, UCSF Weill Institute for Neurosciences University of California San Francisco  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashlin R. 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