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Increasing interest and familiarity with digital imaging highlights recent shifts to modernize pathology workflows by leveraging technology that automates imaging and analysis. This review provides an overview of digital pathology technologies and their associated infrastructure, available open\u2010source and proprietary digital pathology software, relevant background on neurodegenerative histopathological features, and computational research. It further examines recent developments in digital pathology in neurodegenerative disease research with an emphasis on machine learning. We discuss evidence supporting how recently developed technologies and methodologies can enhance our understanding of histopathologic features of neurodegeneration and correlations of histopathologic features with cognitive performance and age at death. Finally, we review potential directions for neurodegenerative disease digital pathology research given trends in technological infrastructure development and other digital pathology research.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>Provides a historical summary of digital pathology with respect to neuropathology.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Examines key digital pathology technologies.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Explores digital pathology applications in neurodegenerative disease and their contribution to research.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Discusses the future of digital neuropathology.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.70775","type":"journal-article","created":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T09:47:57Z","timestamp":1762508877000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Digital neuropathology of neurodegenerative disorders: Foundations, research advances, and future directions"],"prefix":"10.1002","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9710-7220","authenticated-orcid":false,"given":"Aaron M.","family":"Rosado","sequence":"first","affiliation":[{"name":"Emory University School of Medicine Department of Laboratory Medicine and Pathology Emory University Hospital  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan C.","family":"Vizcarra","sequence":"additional","affiliation":[{"name":"Emory University School of Medicine Department of Laboratory Medicine and Pathology Emory University Hospital  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shivam R. Rai","family":"Sharma","sequence":"additional","affiliation":[{"name":"Davis Department of Computer Science University of California  Davis California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristopher Dirk","family":"Keene","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology University of Washington  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"III","given":"Charles L.","family":"White","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Texas Southwestern Medical Center  Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ain","family":"Kim","sequence":"additional","affiliation":[{"name":"Tanz Centre for Research in Neurodegenerative Diseases, Temerty Faculty of Medicine, 1 King's College Circle University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shelley L.","family":"Forrest","sequence":"additional","affiliation":[{"name":"Tanz Centre for Research in Neurodegenerative Diseases, Temerty Faculty of Medicine, 1 King's College Circle University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabor G.","family":"Kovacs","sequence":"additional","affiliation":[{"name":"Tanz Centre for Research in Neurodegenerative Diseases, Temerty Faculty of Medicine, 1 King's College Circle University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen\u2010Nee","family":"Chuah","sequence":"additional","affiliation":[{"name":"Davis Department of Electrical and Computer Engineering University of California  Davis California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret E.","family":"Flanagan","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine University of Texas Health Science Center  San Antonio Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas M.","family":"Pearce","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Pittsburg School of Medicine  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2141-8855","authenticated-orcid":false,"given":"Brittany N.","family":"Dugger","sequence":"additional","affiliation":[{"name":"Davis Department of Pathology and Laboratory Medicine University of California  Sacramento California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Gutman","sequence":"additional","affiliation":[{"name":"Emory University School of Medicine Department of Laboratory Medicine and Pathology Emory University Hospital  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,7]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mpdhp.2025.04.002"},{"key":"e_1_2_8_3_1","first-page":"3","article-title":"From telepathology to virtual pathology institution: the new world of digital pathology","volume":"45","author":"Kayser K","year":"1999","journal-title":"Rom J Morphol Embryol"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0046\u20108177(86)80028\u20104"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0197\u20104580(93)90115\u2010r"},{"key":"e_1_2_8_6_1","unstructured":"BacusJV BacusJW.Method and apparatus for acquiring and reconstructing magnified specimen images from a computer\u2010controlled microscope 2000. 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