{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T18:07:12Z","timestamp":1792260432894,"version":"4.4.0"},"reference-count":40,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:00:00Z","timestamp":1760140800000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100014188","name":"Ministry of Science and ICT, South Korea","doi-asserted-by":"publisher","award":["RS\u20102022\u2010NR070671"],"award-info":[{"award-number":["RS\u20102022\u2010NR070671"]}],"id":[{"id":"10.13039\/501100014188","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014188","name":"Ministry of Science and ICT, South Korea","doi-asserted-by":"publisher","award":["RS\u20102021\u2010NR061838"],"award-info":[{"award-number":["RS\u20102021\u2010NR061838"]}],"id":[{"id":"10.13039\/501100014188","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014188","name":"Ministry of Science and ICT, South Korea","doi-asserted-by":"publisher","award":["RS\u20102023\u201000280087"],"award-info":[{"award-number":["RS\u20102023\u201000280087"]}],"id":[{"id":"10.13039\/501100014188","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014188","name":"Ministry of Science and ICT, South Korea","doi-asserted-by":"publisher","award":["RS\u20102023\u201000243810"],"award-info":[{"award-number":["RS\u20102023\u201000243810"]}],"id":[{"id":"10.13039\/501100014188","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>This study evaluated whether plasma phosphorylated tau\u2010217 (p\u2010tau217), amyloid beta (A\u03b2)42\/40, and their combination could serve as biomarkers of A\u03b2 co\u2010pathology across the Lewy body continuum, where A\u03b2 is frequently observed from prodromal to symptomatic stages.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>Individuals with dementia with Lewy bodies (DLB), Parkinson's disease (PD), and their shared prodromal stage, isolated rapid eye movement (REM) sleep behavior disorder (iRBD) underwent plasma sampling, A\u03b2\u2010PET, and cognitive testing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Higher plasma p\u2010tau217, lower A\u03b242\/40, and their interaction were associated with greater A\u03b2\u2010PET uptake. Individuals with higher\u2010than\u2010median p\u2010tau217 and lower\u2010than\u2010median A\u03b242\/40 showed the highest A\u03b2 burden. Both biomarkers predicted A\u03b2\u2010PET positivity, but only p\u2010tau217 correlated with cognition. Among 44 iRBD participants followed prospectively, elevated baseline p\u2010tau217 predicted phenoconversion to overt Lewy body disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Plasma p\u2010tau217 and A\u03b242\/40 may serve as accessible biomarkers of cerebral A\u03b2 pathology and help identify individuals across the Lewy body continuum who could benefit from A\u03b2\u2010targeted therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>Plasma phosphorylated tau\u2010217 (p\u2010tau217) and amyloid beta (A\u03b2)42\/40 predict cerebral A\u03b2 burden in the Lewy body continuum.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Both biomarkers individually show high accuracy for identifying A\u03b2 positron emission tomography positivity.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Plasma p\u2010tau217, but not A\u03b242\/40, is associated with cognitive performance.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Elevated plasma p\u2010tau217 predicts future phenoconversion in isolated rapid eye movement sleep behavior disorder.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.70788","type":"journal-article","created":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T17:20:49Z","timestamp":1760203249000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Plasma p\u2010tau217 and A\u03b242\/40 as markers of A\u03b2 pathology in the Lewy body continuum"],"prefix":"10.1002","volume":"21","author":[{"given":"Kyung Ah","family":"Woo","sequence":"first","affiliation":[{"name":"Biomedical Research Institute Seoul National University Hospital  Seoul Republic of Korea"},{"name":"Department of Biomedical Informatics Harvard Medical School  Boston Massachusetts USA"},{"name":"Department of Neurology Seoul National University Hospital  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun Jin","family":"Yoon","sequence":"additional","affiliation":[{"name":"Memory Network Medical Research Center Seoul National University  Seoul Republic of Korea"},{"name":"Department of Nuclear Medicine Seoul Metropolitan Government\u2013Seoul National University Boramae Medical Center Seoul National University College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryul","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neurology Seoul Metropolitan Government\u2013Seoul National University Boramae Medical Center Seoul National University College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heejung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Seoul Metropolitan Government\u2013Seoul National University Boramae Medical Center Seoul National University College of Medicine  Seoul Republic of Korea"},{"name":"Institute of Radiation Medicine Medical Research Center Seoul National University  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seoyeon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neurology Inha University Hospital Inha University College of Medicine  Incheon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bora","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Neurology Dong\u2010A University Hospital  Busan Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seungmin","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Neurology Seoul Metropolitan Government\u2013Seoul National University Boramae Medical Center Seoul National University College of Medicine  Seoul Republic of Korea"},{"name":"Institute of Radiation Medicine Medical Research Center Seoul National University  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu Kyeong","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Seoul Metropolitan Government\u2013Seoul National University Boramae Medical Center Seoul National University College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyunwoo","family":"Nam","sequence":"additional","affiliation":[{"name":"Department of Neurology Seoul Metropolitan Government\u2013Seoul National University Boramae Medical Center Seoul National University College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9120-2075","authenticated-orcid":false,"given":"Jee\u2010Young","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Neurology Seoul Metropolitan Government\u2013Seoul National University Boramae Medical Center Seoul National University College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,11]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)00462-6"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(16)30291-5"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000207393"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(24)00402-2"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.30031"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awz030"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.12134"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-021-02275-6"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-021-01348-z"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12841"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-022-02074-w"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000209418"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13653"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awaf003"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2023.5319"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.26424"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000004058"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3956(75)90026-6"},{"key":"e_1_2_9_20_1","volume-title":"Incheon: Human brain research & consulting co","author":"Kang Y","year":"2003"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.24893"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/acn3.51905"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awaf196"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000010942"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2023.105775"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2014.07.003"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-017-3749-6"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2018.09.001"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-021-00807-6"},{"key":"e_1_2_9_30_1","first-page":"1797","article-title":"Plasma p\u2010tau231 and p\u2010tau217 as state markers of amyloid\u2010beta pathology in preclinical Alzheimer's disease","volume":"28","author":"Mila\u2010Aloma M","year":"2022","journal-title":"Nat Med"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2017.06.1071"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(25)00085-7"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2024.5017"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.14584"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3549"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-49402-x"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2019.16439"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2024.2619"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-021-00486-9"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.24939"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.26796"}],"container-title":["Alzheimer's &amp; Dementia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alz.70788","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T12:32:14Z","timestamp":1764160334000},"score":1,"resource":{"primary":{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/10.1002\/alz.70788"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":40,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["10.1002\/alz.70788"],"URL":"https:\/\/doi.org\/10.1002\/alz.70788","archive":["Portico"],"relation":{},"ISSN":["1552-5260","1552-5279"],"issn-type":[{"value":"1552-5260","type":"print"},{"value":"1552-5279","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"2025-06-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70788"}}