{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T22:53:48Z","timestamp":1789080828823,"version":"build-2803163510"},"reference-count":50,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:00:00Z","timestamp":1760140800000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R21NS109833"],"award-info":[{"award-number":["R21NS109833"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["U01AG016976"],"award-info":[{"award-number":["U01AG016976"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["P30AG062421"],"award-info":[{"award-number":["P30AG062421"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000864","name":"Michael J. 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The severity of fluctuating cognition was associated with Lewy body pathology stage after controlling for AD co\u2010pathology. Visual hallucinations were associated with both Lewy body and AD pathologies.\n <\/jats:p>\n <\/jats:sec>\n \n DISCUSSION<\/jats:title>\n \n Core clinical features of DLB are sensitive to\n APOE<\/jats:italic>\n haplotype. Targeting\n APOE<\/jats:italic>\n biology may elucidate DLB pathogenesis and inform therapeutic development.\n <\/jats:p>\n <\/jats:sec>\n \n Highlights<\/jats:title>\n \n \n \n \n Core clinical features of dementia with Lewy bodies were sensitive to apolipoprotein E (\n APOE<\/jats:italic>\n ) haplotype.\n <\/jats:p>\n <\/jats:list-item>\n \n \n APOE<\/jats:italic>\n \u03b54 was associated with a higher likelihood of hallucinations yet a lower likelihood of cognitive fluctuations.\n <\/jats:p>\n <\/jats:list-item>\n \n \n APOE<\/jats:italic>\n \u03b54 was associated with greater severity of Lewy body pathology, partially mediated by Alzheimer's disease (AD) co\u2010pathology.\n <\/jats:p>\n <\/jats:list-item>\n \n Whereas fluctuating cognition was primarily linked to Lewy body pathology, visual hallucinations were associated with both Lewy body and AD neuropathologic changes.<\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/alz.70795","type":"journal-article","created":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T14:40:14Z","timestamp":1760193614000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["APOE<\/i>\n \u03b54 linked effects on clinical features and neuropathology in dementia with Lewy bodies"],"prefix":"10.1002","volume":"21","author":[{"given":"Rong","family":"Ye","sequence":"first","affiliation":[{"name":"Department of Neurology, Massachusetts General Hospital Boston Massachusetts USA"},{"name":"Harvard Medical School Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna E.","family":"Goodheart","sequence":"additional","affiliation":[{"name":"Department of Neurology, Massachusetts General Hospital Boston Massachusetts USA"},{"name":"Harvard Medical School Boston Massachusetts 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