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However, this has not been well studied in adults with Down syndrome (DS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      The prevalence of MetS and its subcomponents was examined in adults with DS using the Alzheimer Biomarkers Consortium \u2013 Down Syndrome data (ABC\u2010DS,\n                      <jats:italic>N<\/jats:italic>\n                      \u00a0=\u00a0389). Logistic regression was used to examine the relationship between MetS and AD at baseline visits.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Prevalence of MetS, diabetes, hypertension, and hyperlipidemia was low with DS, even though the prevalence of obesity was elevated. Obesity was positively associated with AD in adults with DS (odds ratio\u00a0=\u00a02.79,\n                      <jats:italic>P\u00a0<\/jats:italic>\n                      =\u00a00.021), but there was no association between MetS and AD in DS.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>The prevalence of MetS was low in adults with DS. Although MetS was not associated with AD, obesity, a subcomponent of MetS, was associated with AD in adults with DS. This may inform targeted treatments in the future.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>There was a low prevalence of metabolic syndrome (MetS) in adults with Down syndrome (DS).<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Overall MetS was not associated with dementia in adults with DS.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Obesity, a subcomponent of MetS, had a high prevalence in adults with DS.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Obesity was positively associated with dementia in adults with DS.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.70799","type":"journal-article","created":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T10:21:57Z","timestamp":1760696517000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Examination of metabolic syndrome in Down syndrome and association with dementia"],"prefix":"10.1002","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-9252-0789","authenticated-orcid":false,"given":"Dina","family":"Dass","sequence":"first","affiliation":[{"name":"Columbia University Irving Medical Center  New York New York USA"},{"name":"Taub Institute for Research on Alzheimer's Disease and the Aging Brain  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lam\u2010Ha T.","family":"Dang","sequence":"additional","affiliation":[{"name":"Columbia University Irving Medical Center  New York New York USA"},{"name":"Taub Institute for Research on Alzheimer's Disease and the Aging Brain  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Xicota","sequence":"additional","affiliation":[{"name":"Columbia University Irving Medical Center  New York New York USA"},{"name":"Taub Institute for Research on Alzheimer's Disease and the Aging Brain  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon","family":"Krinsky\u2010McHale","sequence":"additional","affiliation":[{"name":"Department of Psychology NYS Institute for Basic Research in Developmental Disabilities  Staten Island New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Balaji","family":"Kannappan","sequence":"additional","affiliation":[{"name":"Columbia University Irving Medical Center  New York New York USA"},{"name":"Taub Institute for Research on Alzheimer's Disease and the Aging Brain  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam M.","family":"Brickman","sequence":"additional","affiliation":[{"name":"Columbia University Irving Medical Center  New York New York USA"},{"name":"Taub Institute for Research on Alzheimer's Disease and the Aging Brain  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradley T.","family":"Christian","sequence":"additional","affiliation":[{"name":"University of Wisconsin\u2010Madison  Madison Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Head","sequence":"additional","affiliation":[{"name":"Department of Pathology &amp; Laboratory Medicine University of California, Irvine  Irvine California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sid E.","family":"O'Bryant","sequence":"additional","affiliation":[{"name":"University of North Texas, Health Science Center at Fort Worth  Fort Worth Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Mapstone","sequence":"additional","affiliation":[{"name":"University of California, Irvine  Irvine California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Handen","sequence":"additional","affiliation":[{"name":"University of Pittsburgh Medical Center  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Marder","sequence":"additional","affiliation":[{"name":"Columbia University Irving Medical Center  New York New York USA"},{"name":"Taub Institute for Research on Alzheimer's Disease and the Aging Brain  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2000-4821","authenticated-orcid":false,"given":"Joseph H.","family":"Lee","sequence":"additional","affiliation":[{"name":"Columbia University Irving Medical Center  New York New York USA"},{"name":"Taub Institute for Research on Alzheimer's Disease and the Aging Brain  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Alzheimer Biomarker Consortium \u2013 Down syndrome (ABC\u2010DS)","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,17]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/1753944717711379"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.hjh.0000217840.26971.b6"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/497802"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24054354"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12112"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410430316"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.4102\/ajod.v8i0.576"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651\u20102227.2008.01197.x"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/dneu.22709"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ridd.2014.07.038"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/jir.13103"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1352\/0895\u20108017(2004)109<186:NSARFF>2.0.CO;2"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/fampra\/cmq079"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2015.11.007"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci8040053"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/dad2.12065"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/514589"},{"key":"e_1_2_11_19_1","volume-title":"R: A Language and Environment for Statistical Computing","year":"2023"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD\u2010220865"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/jir.12767"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.15620\/cdc\/159281"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/postmj\/qgad008"}],"container-title":["Alzheimer's &amp; 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