{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T14:43:31Z","timestamp":1791816211356,"version":"4.3.4"},"reference-count":49,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T00:00:00Z","timestamp":1761782400000},"content-version":"vor","delay-in-days":29,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000957","name":"Alzheimer's Association","doi-asserted-by":"publisher","award":["SG21\u2010818099\u2010EPAD"],"award-info":[{"award-number":["SG21\u2010818099\u2010EPAD"]}],"id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001826","name":"ZonMw","doi-asserted-by":"publisher","award":["#73305095007"],"award-info":[{"award-number":["#73305095007"]}],"id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001826","name":"ZonMw","doi-asserted-by":"publisher","award":["#10510032120003"],"award-info":[{"award-number":["#10510032120003"]}],"id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["#2023\u201000356"],"award-info":[{"award-number":["#2023\u201000356"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["#2022\u201001018"],"award-info":[{"award-number":["#2022\u201001018"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["#2019\u201002397"],"award-info":[{"award-number":["#2019\u201002397"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007625","name":"Cure Alzheimer's Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007625","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>It remains unclear whether diabetes mellitus (DM) is associated with Alzheimer's disease (AD) pathology and associated vascular burden.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>We included cognitively normal (CN), mild cognitive impairment (MCI), and dementia individuals. We assessed associations between DM and AD biomarkers (amyloid beta [A\u03b2], phosphorylated tau\u2010181 [p\u2010tau181], total tau [t\u2010tau], and medial temporal atrophy [MTA]) and vascular burden (white matter hyperintensities, microbleeds) by logistic regression. Secondary analyses assessed associations between DM and profiles of A\u03b2 combined with p\u2010tau181\/t\u2010tau\/MTA\/white matter hyperintensity\/microbleeds.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      We included 5550 participants (65.8+\u20108.7 years, 8.7% DM). DM was associated with lower odds of abnormal AD biomarkers: A\u03b2 in MCI (odds ratio [OR]\u00a0=\u00a00.70, 95% confidence interval [CI]: 0.51\u20130.95,\n                      <jats:italic>p\u00a0<\/jats:italic>\n                      =\u00a00.02) and dementia (OR\u00a0=\u00a00.44, 0.26\u20130.78,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.003), and p\u2010tau181 in dementia (OR\u00a0=\u00a00.64, 0.41\u20131.00,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.045). Secondary analyses indicated associations of DM with abnormal t\u2010tau (OR\u00a0=\u00a01.57, 1.00\u20132.46,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.048) and MTA (OR\u00a0=\u00a01.96, 1.05\u20133.68,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.04) only in CN individuals with normal A\u03b2.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>In cognitively impaired individuals, DM was associated with lower odds of A\u03b2 pathology, whereas DM was associated with neurodegeneration markers in CN individuals without A\u03b2 pathology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>Diabetes mellitus (DM) was associated with lower odds of amyloid beta (A\u03b2) and phosphorylated tau (p\u2010tau) pathology across clinical populations.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>DM was associated with total tau and medial temporal atrophy in cognitively normal individuals without A\u03b2 pathology.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>DM may be associated with dementia through neurodegenerative pathways other than Alzheimer's disease.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.70804","type":"journal-article","created":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T10:59:47Z","timestamp":1761821987000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The association of diabetes with Alzheimer's disease biomarkers and vascular burden across European aging and memory clinic cohorts"],"prefix":"10.1002","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8240-5367","authenticated-orcid":false,"given":"Veerle","family":"van Gils","sequence":"first","affiliation":[{"name":"Alzheimer Center Limburg Mental Health and Neuroscience Research Institute Maastricht University Maastricht Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Willemijn J.","family":"Jansen","sequence":"additional","affiliation":[{"name":"Alzheimer Center Limburg Mental Health and Neuroscience Research Institute Maastricht University Maastricht Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wiesje M.","family":"van der Flier","sequence":"additional","affiliation":[{"name":"Alzheimer Center and Department of Neurology Amsterdam Neuroscience Campus VU University Medical Center  Amsterdam Netherlands"},{"name":"Amsterdam Neuroscience, Neurodegeneration  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Martinez\u2010Lage","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3n CITA\u2010Alzh\u00e9imer Fundazioa  Donostia Gipuzkoa Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jakub","family":"Hort","sequence":"additional","affiliation":[{"name":"Charles University, 2nd Faculty of Medicine Motol University Hospital  Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inez H. 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