{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T04:38:45Z","timestamp":1790829525643,"version":"4.1.0"},"reference-count":95,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T00:00:00Z","timestamp":1761177600000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>We examined the association between low\u2010frequency oscillations in blood pressure variability (LF\u2010BPV) at baseline (past) and 12 years later (concurrent) and BrainAGE gap (an indicator of brain health).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>Participants were 110 adults (age range 37\u201383 years at baseline, 60% female) from the Midlife in the United States (MIDUS) study. LF\u2010BPV (0.04\u20130.15\u00a0Hz) was spectrally decomposed from beat\u2010to\u2010beat BP waveforms acquired from finger photoplethysmography. BrainAGE was estimated using a Gaussian\u2010process regression model applied to raw T1\u2010weighted magnetic resonance imaging (MRI) scans. BrainAGE gap was calculated as brain age minus chronological age.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      After adjustment for covariates, higher past diastolic LF\u2010BPV was associated with significantly reduced BrainAGE gap (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u00a0=\u00a0\u22122.24; 95% CI \u22124.15, \u22120.32,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.022), as was higher concurrent diastolic LF\u2010BPV (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u00a0=\u00a0\u22121.90; 95% CI \u22123.68, \u22120.12,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.037).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>Our findings suggest that low\u2010frequency oscillations in diastolic BPV are associated with slower brain aging relative to chronological age.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>Low\u2010frequency oscillations in diastolic blood pressure variability, a marker of vasomotion, are reduced with aging.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Low\u2010frequency oscillations in diastolic blood pressure variability are favorably associated with BrainAGE gap, a marker of overall brain health, measured from neuroimaging.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Reductions in vasomotion with aging may contribute to accelerated brain aging relative to chronological age.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.70833","type":"journal-article","created":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T10:49:45Z","timestamp":1761216585000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Association between low\u2010frequency oscillations in blood pressure variability and brain age derived from neuroimaging"],"prefix":"10.1002","volume":"21","author":[{"given":"Kevin S.","family":"Heffernan","sequence":"first","affiliation":[{"name":"Department of Biobehavioral Sciences Applied Physiology Teachers College Columbia University  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jill N.","family":"Barnes","sequence":"additional","affiliation":[{"name":"Bruno Balke Biodynamics Laboratory 253 Bardeen Medical Laboratories University of Wisconsin\u2010Madison  Madison Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew S.","family":"London","sequence":"additional","affiliation":[{"name":"Department of Sociology and the Aging Studies Institute Syracuse University  Syracuse New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derek C.","family":"Monroe","sequence":"additional","affiliation":[{"name":"Department of Exercise and Sport Science University of North Carolina at Chapel Hill  Chapel Hill North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaakov","family":"Stern","sequence":"additional","affiliation":[{"name":"Cognitive Neuroscience Division Department of Neurology Columbia University, Vagelos College of Physicians and Surgeons  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard P.","family":"Sloan","sequence":"additional","affiliation":[{"name":"Division of Behavioral Medicine Department of Psychiatry Columbia University Irving Medical Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stacey M.","family":"Schaefer","sequence":"additional","affiliation":[{"name":"Institute on Aging 2245C Medical Sciences Center University of Wisconsin\u2010Madison  Madison Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,23]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvaf010"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2014.00120"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0000000000003133"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.121.17797"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.25.6.1276"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2002.017483"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1681.2007.04588.x"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1999.276.4.H1245"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00007.2009"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP282605"},{"key":"e_1_2_8_12_1","first-page":"1","article-title":"Arteriolar Vasomotion: implications for Tissue Ischemia","volume":"28","author":"Intaglietta M","year":"2008","journal-title":"Blood Vessels"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00438.2024"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1113\/EP087358"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.25392"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2022.940140"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2024.11.027"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X211064846"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11906-022-01200-w"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2017.62"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2017.10.001"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2017.07.059"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-024-03209-x"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000000517"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2023.6431"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehaa756"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000145857.98904.20"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2016.03.012"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(19)30228-5"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2023.1234427"},{"key":"e_1_2_8_31_1","first-page":"H1427","article-title":"Blood pressure variability responses to tilt are buffered by cardiac autonomic control","volume":"273","author":"Sloan RP","year":"1997","journal-title":"Am J Physiol"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02441589"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1109\/TBME.1984.325351"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1109\/PROC.1978.10837"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.26502"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2023.09.003"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.24899"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2019.06.017"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2023.103319"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/dad2.70094"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2022.103175"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2020.03.014"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0157514"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-019-0626-7"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2018.00074"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000207219"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00406\u2010024\u201001758\u20103"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1093\/geroni\/igac059.2834"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.6.4.579"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00114.2009"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI557"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1991.260.2.H362"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mvr.2006.05.006"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1111\/micc.12546"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2022.08.012"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2018.04.045"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2019.00433"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2010.06.001"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1117\/1.JBO.17.10.106004"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2024.1457732"},{"key":"e_1_2_8_61_1","article-title":"Hemodynamic and neuronal contributions to low\u2010frequency vascular oscillations in a preclinical model of Alzheimer's disease","volume":"12","author":"O'Connor SM","year":"2025","journal-title":"Neurophotonics"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2015.166"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.1109\/MEMB.2009.934908"},{"key":"e_1_2_8_64_1","first-page":"75","article-title":"Evidence of flowmotion induced changes in local tissue oxygenation","volume":"12","author":"Tsai AG","year":"1993","journal-title":"Int J Microcirc Clin Exp"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.1006\/jtbi.2000.2254"},{"key":"e_1_2_8_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2017.10.012"},{"key":"e_1_2_8_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2013.10.044"},{"key":"e_1_2_8_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2019.10.033"},{"key":"e_1_2_8_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2010.11.016"},{"key":"e_1_2_8_70_1","doi-asserted-by":"publisher","DOI":"10.1093\/braincomms\/fcaf007"},{"key":"e_1_2_8_71_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-142976"},{"key":"e_1_2_8_72_1","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2013.4"},{"key":"e_1_2_8_73_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10877-019-00387-9"},{"key":"e_1_2_8_74_1","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X221119760"},{"key":"e_1_2_8_75_1","doi-asserted-by":"publisher","DOI":"10.3389\/fragi.2022.1077302"},{"key":"e_1_2_8_76_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00581.2016"},{"key":"e_1_2_8_77_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-132018"},{"key":"e_1_2_8_78_1","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2013.180"},{"key":"e_1_2_8_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2025.106845"},{"key":"e_1_2_8_80_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-191073"},{"key":"e_1_2_8_81_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.WCB.0000135231.90164.40"},{"key":"e_1_2_8_82_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jcbfm.9600159"},{"key":"e_1_2_8_83_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0000000000003935"},{"key":"e_1_2_8_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autneu.2004.09.003"},{"key":"e_1_2_8_85_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000006000"},{"key":"e_1_2_8_86_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.24.1.120"},{"key":"e_1_2_8_87_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/54.5.B219"},{"key":"e_1_2_8_88_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.116.08986"},{"key":"e_1_2_8_89_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1977.sp012051"},{"key":"e_1_2_8_90_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11357-024-01303-z"},{"key":"e_1_2_8_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ynirp.2024.100198"},{"key":"e_1_2_8_92_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-20627-4"},{"key":"e_1_2_8_93_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajh\/hpac108"},{"key":"e_1_2_8_94_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.101.8.862"},{"key":"e_1_2_8_95_1","doi-asserted-by":"publisher","DOI":"10.1093\/function\/zqac029"},{"key":"e_1_2_8_96_1","doi-asserted-by":"publisher","DOI":"10.1101\/2025.01.16.633271"}],"container-title":["Alzheimer's &amp; Dementia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alz.70833","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T12:33:19Z","timestamp":1764160399000},"score":1,"resource":{"primary":{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/10.1002\/alz.70833"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":95,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["10.1002\/alz.70833"],"URL":"https:\/\/doi.org\/10.1002\/alz.70833","archive":["Portico"],"relation":{},"ISSN":["1552-5260","1552-5279"],"issn-type":[{"value":"1552-5260","type":"print"},{"value":"1552-5279","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"2025-05-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70833"}}