{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T01:19:31Z","timestamp":1789175971438,"version":"build-2803163510"},"reference-count":44,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,11,9]],"date-time":"2025-11-09T00:00:00Z","timestamp":1762646400000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["DGE\u20101839285"],"award-info":[{"award-number":["DGE\u20101839285"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>Neuropsychiatric symptoms (NPS) are common as Alzheimer's disease (AD) dementia emerges, both in older adults (OA) and in individuals with Down syndrome (DS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>We compared neuropsychiatric inventory (NPI) scores and NPI score trajectories in large cohorts of individuals with DS and OA. Participants were stratified as cognitively normal\/stable, mild cognitive impairment, or dementia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      The pattern of NPI domain scores in cohorts with DS (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0396) or OA (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a035,217) were qualitatively similar across\u00a0the cognitive groups. The relationships between cognitive group and both the NPI total score and the rate of NPI score change over time were similar in the two cohorts (multivariate Wald test,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.28 and\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.52, respectively).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>These findings support a conjecture that the shared pathophysiology among individuals with DS and OA may be reflected in the similar clinical profiles and clinical trajectories. NPS are important considerations in the early diagnosis and clinical management.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>Neuropsychiatric symptoms (NPS) often precede cognitive decline in late\u2010onset AD.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>People with Down syndrome (DS) are a vulnerable population for AD.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Psychiatric symptoms in people with DS and emergent dementia are poorly understood.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Symptoms in people with DS and older adults (OA) were similar across cognitive groups.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Similar symptoms in the two groups may reflect shared amyloid or related pathology.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.70871","type":"journal-article","created":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T03:19:11Z","timestamp":1762744751000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Neuropsychiatric symptoms and emerging dementia in people with Down syndrome and older adults"],"prefix":"10.1002","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0133-1875","authenticated-orcid":false,"given":"Christina M.","family":"Magana\u2010Ramirez","sequence":"first","affiliation":[{"name":"Department of Statistics University of California  Irvine California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel L.","family":"Gillen","sequence":"additional","affiliation":[{"name":"Department of Statistics University of California  Irvine California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christy L.","family":"Hom","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Human Behavior University of California  Irvine California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Lidio","family":"Jaimes","sequence":"additional","affiliation":[{"name":"Department of Statistics University of Georgia  Athens Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Srisai Saavarni","family":"Chilukuri","sequence":"additional","affiliation":[{"name":"Department of Statistics University of California  Riverside California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noah","family":"McMahon","sequence":"additional","affiliation":[{"name":"Department of Statistics University of Washington  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Casie","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Statistics University of Florida  Gainesville Florida USA"},{"name":"Department of Economics University of Florida  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan","family":"Kuhlman","sequence":"additional","affiliation":[{"name":"Department of Economics University of California  San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiffany","family":"Hu","sequence":"additional","affiliation":[{"name":"School of Medicine University of California  Irvine California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Head","sequence":"additional","affiliation":[{"name":"Departments of Pathology and Laboratory Medicine and Neurology University of California  Irvine California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ira T.","family":"Lott","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of California  Irvine California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David L.","family":"Sultzer","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Human Behavior University of California  Irvine California 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