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Of 52 A\u03b2 binding partners, suggested by non\u2010human studies, levels of 34 together with total A\u03b2 protein were quantified in the dorsolateral prefrontal cortex.\n                      <jats:italic>Post mortem<\/jats:italic>\n                      pathological assessment immunohistochemically quantified A\u03b2 load and tau tangle density.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>The strongest mediations between A\u03b2 and tau tangles were observed for Ras\u2010related C3 botulinum toxin substrate 1 (RAC1) and sodium\/potassium\u2010transporting ATPase subunit alpha\u20103 (ATP1A3), which collectively mediated 10.1% of the association between A\u03b2 and tau tangles. In contrast, A\u03b2 mediated\u00a0&gt;70% of the associations of matrix proteins with tau tangles.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Identification of A\u03b2 binding partners that mediate the association between A\u03b2 and tau tangles may provide new targets for AD treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>RAC1 linked A\u03b2 with tau tangles.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>ATP1A3 linked A\u03b2 with tau.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>RAC1 and ATP1A3 collectively mediated 10.1% of the association between A\u03b2 and tau.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>A\u03b2 mediated\u00a0&gt;70% of the associations of matrix proteins, such as APOE, with tau.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.70882","type":"journal-article","created":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T10:40:16Z","timestamp":1762857616000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Amyloid beta binding partners in the brain tissue of older adults"],"prefix":"10.1002","volume":"21","author":[{"given":"Shahram","family":"Oveisgharan","sequence":"first","affiliation":[{"name":"Rush Alzheimer's Disease Center Rush University Medical Center  Chicago Illinois USA"},{"name":"Department of Neurological Sciences Rush University Medical Center  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Yu","sequence":"additional","affiliation":[{"name":"Rush Alzheimer's Disease Center Rush University Medical Center  Chicago Illinois USA"},{"name":"Department of Neurological Sciences Rush University Medical Center  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanling","family":"Wang","sequence":"additional","affiliation":[{"name":"Rush Alzheimer's Disease Center Rush University Medical Center  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyun","family":"Yang","sequence":"additional","affiliation":[{"name":"Rush Alzheimer's Disease Center Rush University Medical Center  Chicago Illinois USA"},{"name":"Department of Neurological Sciences Rush University Medical Center  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USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tracey L.","family":"Young\u2010Pearse","sequence":"additional","affiliation":[{"name":"Ann Romney Center for Neurologic Diseases, Department of Neurology Brigham and Women's Hospital and Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip L","family":"De Jager","sequence":"additional","affiliation":[{"name":"Center for Translational &amp; Computational Neuroimmunology, Department of Neurology Columbia University Irving Medical Center  New York New York USA"},{"name":"Taub Institute for Research on Alzheimer's Disease and the Aging Brain Columbia University Irving Medical Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladislav A.","family":"Petyuk","sequence":"additional","affiliation":[{"name":"Biological Sciences Division Pacific Northwest National Laboratory  Richland Washington 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