{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T00:53:51Z","timestamp":1792457631788,"version":"4.5.0"},"reference-count":363,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T00:00:00Z","timestamp":1764201600000},"content-version":"vor","delay-in-days":26,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000957","name":"Alzheimer's Association","doi-asserted-by":"publisher","award":["24AARF\u20101242638"],"award-info":[{"award-number":["24AARF\u20101242638"]}],"id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006312","name":"BrightFocus Foundation","doi-asserted-by":"publisher","award":["A2024012F"],"award-info":[{"award-number":["A2024012F"]}],"id":[{"id":"10.13039\/100006312","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000143","name":"Alzheimer Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000143","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>Recent studies have highlighted retinal optical coherence tomography (OCT) imaging as a promising biomarker for the early detection of Alzheimer's disease (AD). This review connects AD brain pathology \u2013 particularly amyloid beta (A\u03b2), tau, and vascular changes \u2013 with corresponding retinal changes. Evidence suggests that abnormal A\u03b2 and tau deposits in the retina may reflect brain pathology, though their formation mechanisms remain unclear. Retinal vascular changes may also mirror brain pathology, with recent data emerging on other co\u2010pathologies. Retinal thickness changes, especially in acetylcholine\u2010producing layers, can differentiate AD from controls, although not in early AD; however, emerging high\u2010resolution OCT techniques may enhance early detection. We find that correlations between retinal thickness and brain structures are often weak, and retinal vascular imaging shows promise in estimating cerebrovascular disease markers from retinal vascular changes. Novel imaging modalities (e.g., hyperspectral imaging) for detecting retinal A\u03b2 deposits may improve early AD screening when combined with other biomarkers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>Retinal A\u03b2\/tau is equivocal; peripheral retinal p\u2010tau shows diagnostic promise.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>OCT retinal\/choroid thickness diagnostic\/prognostic AUC is small to medium.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Hyperspectral imaging and electroretinography may aid early diagnosis.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>OCTA may differentiate MCI from controls, but preclinical studies are needed.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>The added value of retinal biomarkers for risk stratification remains uncertain.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.70884","type":"journal-article","created":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T09:45:42Z","timestamp":1764236742000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Brain and retina in Alzheimer's disease: Pathological intersections and estimates from imaging"],"prefix":"10.1002","volume":"21","author":[{"given":"M. Amin","family":"Banihashemi","sequence":"first","affiliation":[{"name":"Temerty Faculty of Medicine University of Toronto  Toronto Ontario Canada"},{"name":"Centre for Brain Resilience and Recovery Hurvitz Brain Sciences Program Sunnybrook Research Institute University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saffire H.","family":"Krance","sequence":"additional","affiliation":[{"name":"Centre for Brain Resilience and Recovery Hurvitz Brain Sciences Program Sunnybrook Research Institute University of Toronto  Toronto Ontario Canada"},{"name":"Schulich School of Medicine and Dentistry University of Western Ontario  London Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick Xiang","family":"Ji","sequence":"additional","affiliation":[{"name":"Centre for Brain Resilience and Recovery Hurvitz Brain Sciences Program Sunnybrook Research Institute University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morgan","family":"Koo","sequence":"additional","affiliation":[{"name":"Centre for Brain Resilience and Recovery Hurvitz Brain Sciences Program Sunnybrook Research Institute University of Toronto  Toronto Ontario Canada"},{"name":"School of Public Health Sciences University of Waterloo  Waterloo Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Ottoy","sequence":"additional","affiliation":[{"name":"Temerty Faculty of Medicine University of Toronto  Toronto Ontario Canada"},{"name":"Centre for Brain Resilience and Recovery Hurvitz Brain Sciences Program Sunnybrook Research Institute University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard H.","family":"Swartz","sequence":"additional","affiliation":[{"name":"Temerty Faculty of Medicine University of Toronto  Toronto Ontario Canada"},{"name":"Centre for Brain Resilience and Recovery Hurvitz Brain Sciences Program Sunnybrook Research Institute University of Toronto  Toronto Ontario Canada"},{"name":"Department of Medicine Division of Neurology Sunnybrook Health Sciences Centre University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter J.","family":"Kertes","sequence":"additional","affiliation":[{"name":"Temerty Faculty of Medicine University of Toronto  Toronto Ontario Canada"},{"name":"Centre for Brain Resilience and Recovery Hurvitz Brain Sciences Program Sunnybrook Research Institute University of Toronto  Toronto Ontario Canada"},{"name":"Department of Ophthalmology and Vision Sciences University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Hudson","sequence":"additional","affiliation":[{"name":"Temerty Faculty of Medicine University of Toronto  Toronto Ontario Canada"},{"name":"Department of Ophthalmology and Vision Sciences University of Toronto  Toronto Ontario Canada"},{"name":"School of Optometry and Vision Science University of Waterloo 200 University Avenue West  Waterloo Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maged","family":"Goubran","sequence":"additional","affiliation":[{"name":"Centre for Brain Resilience and Recovery Hurvitz Brain Sciences Program Sunnybrook Research Institute University of Toronto  Toronto Ontario Canada"},{"name":"Department of Medical Biophysics University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7093-8289","authenticated-orcid":false,"given":"Sandra E.","family":"Black","sequence":"additional","affiliation":[{"name":"Temerty Faculty of Medicine University of Toronto  Toronto Ontario Canada"},{"name":"Centre for Brain Resilience and Recovery Hurvitz Brain Sciences Program Sunnybrook Research Institute University of Toronto  Toronto Ontario Canada"},{"name":"Department of Medicine Division of Neurology Sunnybrook Health Sciences Centre University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,27]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2018.08.009"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2022.4845"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.14706"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2017.09.003"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.24246"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-200735"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glaa135"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-58399-4"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2019.00288"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2018.1578"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dadm.2018.01.003"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-160907"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2018.02.018"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-05542-4_2"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-170261"},{"key":"e_1_2_14_17_1","first-page":"253","article-title":"Evaluating early dementia with and without assessment of regional cerebral metabolism by PET: a comparison of predicted costs and benefits","volume":"43","author":"Silverman DH","year":"2002","journal-title":"J Nucl Med"},{"key":"e_1_2_14_18_1","first-page":"1","article-title":"The appropriate use of neuroimaging in the diagnostic work\u2010up of dementia: an economic literature review and cost\u2010effectiveness analysis","volume":"14","author":"Bermingham SL","year":"2014","journal-title":"Ont Health Technol Assess Ser"},{"key":"e_1_2_14_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41433-018-0297-7"},{"key":"e_1_2_14_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/s41073-019-0064-8"},{"key":"e_1_2_14_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2024.102599"},{"key":"e_1_2_14_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2024.102548"},{"key":"e_1_2_14_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2024.102639"},{"key":"e_1_2_14_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trci.2018.06.014"},{"key":"e_1_2_14_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2021.101361"},{"key":"e_1_2_14_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13424"},{"key":"e_1_2_14_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2020.100938"},{"key":"e_1_2_14_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13529"},{"key":"e_1_2_14_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.pbr.2019.03.017"},{"key":"e_1_2_14_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/wcs.1206"},{"key":"e_1_2_14_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awv236"},{"key":"e_1_2_14_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.14036"},{"key":"e_1_2_14_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2000.tb05560.x"},{"key":"e_1_2_14_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.23415"},{"key":"e_1_2_14_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2021.135895"},{"key":"e_1_2_14_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/0301-0082(91)90006-M"},{"key":"e_1_2_14_37_1","first-page":"147","article-title":"Evolution and development of complex eyes: a celebration of diversity","author":"Koenig KM","year":"2020","journal-title":"Development"},{"key":"e_1_2_14_38_1","volume-title":"Neuroanatomy : text and atlas","author":"Martin JH","year":"2020"},{"key":"e_1_2_14_39_1","first-page":"3","article-title":"Phylogenetic and ontogenetic aspects of the basal forebrain cholinergic neurons and their innervation of the cerebral cortex","volume":"145","author":"Semba K","year":"2004","journal-title":"Prog Brain Res"},{"key":"e_1_2_14_40_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a008391"},{"key":"e_1_2_14_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/cga.12304"},{"key":"e_1_2_14_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1534-5807(04)00027-9"},{"key":"e_1_2_14_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-50309-w"},{"key":"e_1_2_14_44_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aao2825"},{"key":"e_1_2_14_45_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2014.00113"},{"key":"e_1_2_14_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2014.05.004"},{"key":"e_1_2_14_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-018-0013-z"},{"key":"e_1_2_14_48_1","doi-asserted-by":"publisher","DOI":"10.1097\/NEN.0b013e31825018f7"},{"key":"e_1_2_14_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-49300-2"},{"key":"e_1_2_14_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-020-0687-6"},{"key":"e_1_2_14_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(19)30079-1"},{"key":"e_1_2_14_52_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12750"},{"key":"e_1_2_14_53_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-200339"},{"key":"e_1_2_14_54_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000271090.28148.24"},{"key":"e_1_2_14_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)03589-3"},{"key":"e_1_2_14_56_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awz099"},{"key":"e_1_2_14_57_1","doi-asserted-by":"publisher","DOI":"10.1186\/alzrt155"},{"key":"e_1_2_14_58_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24903"},{"key":"e_1_2_14_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2018.07.222"},{"key":"e_1_2_14_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(15)70016-5"},{"key":"e_1_2_14_61_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3639.2000.tb00269.x"},{"key":"e_1_2_14_62_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-022-02024-7"},{"key":"e_1_2_14_63_1","doi-asserted-by":"publisher","DOI":"10.1097\/NEN.0b013e318232a379"},{"key":"e_1_2_14_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2020.03.012"},{"key":"e_1_2_14_65_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-018-1855-6"},{"key":"e_1_2_14_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(14)70252-2"},{"key":"e_1_2_14_67_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12192"},{"key":"e_1_2_14_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/0197-4580(95)00021-6"},{"key":"e_1_2_14_69_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awab262"},{"key":"e_1_2_14_70_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awab314"},{"key":"e_1_2_14_71_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-006-0127-z"},{"key":"e_1_2_14_72_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnen\/60.11.1075"},{"key":"e_1_2_14_73_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-121864"},{"key":"e_1_2_14_74_1","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci9070168"},{"key":"e_1_2_14_75_1","first-page":"445","article-title":"Detection of hyperphosphorylated tau protein and alpha\u2010synuclein in spinal cord of patients with Alzheimer's disease","volume":"12","author":"Guo Y","year":"2016","journal-title":"Neuropsychiatr Dis Treat"},{"key":"e_1_2_14_76_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20100"},{"key":"e_1_2_14_77_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhz224"},{"key":"e_1_2_14_78_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncir.2018.00008"},{"key":"e_1_2_14_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2016.09.006"},{"key":"e_1_2_14_80_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-12679-1_1"},{"key":"e_1_2_14_81_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.58.12.1791"},{"key":"e_1_2_14_82_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-018-1868-1"},{"key":"e_1_2_14_83_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awt188"},{"key":"e_1_2_14_84_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25246"},{"key":"e_1_2_14_85_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.111.627562"},{"key":"e_1_2_14_86_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-020-02215-w"},{"key":"e_1_2_14_87_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11011-021-00814-4"},{"key":"e_1_2_14_88_1","doi-asserted-by":"publisher","DOI":"10.1097\/NEN.0b013e3181a6ee45"},{"key":"e_1_2_14_89_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.82.13.4531"},{"key":"e_1_2_14_90_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2377-9-3"},{"key":"e_1_2_14_91_1","doi-asserted-by":"publisher","DOI":"10.1007\/s007020200068"},{"key":"e_1_2_14_92_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-003-0796-9"},{"key":"e_1_2_14_93_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.28.7.1418"},{"key":"e_1_2_14_94_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25123"},{"key":"e_1_2_14_95_1","doi-asserted-by":"publisher","DOI":"10.1002\/1531-8249(200101)49:1<53::AID-ANA30>3.0.CO;2-Q"},{"key":"e_1_2_14_96_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2990.1995.tb01078.x"},{"key":"e_1_2_14_97_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00688200"},{"key":"e_1_2_14_98_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-022-02525-1"},{"key":"e_1_2_14_99_1","doi-asserted-by":"publisher","DOI":"10.1111\/nan.12249"},{"key":"e_1_2_14_100_1","first-page":"1719","article-title":"Lateral geniculate nucleus: anatomic and functional identification by use of MR imaging","volume":"22","author":"Fujita N","year":"2001","journal-title":"AJNR Am J Neuroradiol"},{"key":"e_1_2_14_101_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0197-4580(01)00235-4"},{"key":"e_1_2_14_102_1","doi-asserted-by":"publisher","DOI":"10.1111\/aos.13319"},{"key":"e_1_2_14_103_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-199901000-00004"},{"key":"e_1_2_14_104_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198608213150804"},{"key":"e_1_2_14_105_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-540-37652-1_4"},{"key":"e_1_2_14_106_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2016.00267"},{"key":"e_1_2_14_107_1","doi-asserted-by":"publisher","DOI":"10.2174\/1567205018666210414113634"},{"key":"e_1_2_14_108_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40478-018-0650-x"},{"key":"e_1_2_14_109_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(89)90653-7"},{"key":"e_1_2_14_110_1","doi-asserted-by":"publisher","DOI":"10.1016\/0197-4580(96)00009-7"},{"key":"e_1_2_14_111_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.18-25966"},{"key":"e_1_2_14_112_1","doi-asserted-by":"publisher","DOI":"10.1111\/bpa.12070"},{"key":"e_1_2_14_113_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnen\/nlx020"},{"key":"e_1_2_14_114_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2020.00758"},{"key":"e_1_2_14_115_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2010.06.020"},{"key":"e_1_2_14_116_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.13-12888"},{"key":"e_1_2_14_117_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0053547"},{"key":"e_1_2_14_118_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24548"},{"key":"e_1_2_14_119_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-023-02548-2"},{"key":"e_1_2_14_120_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2018.2505"},{"key":"e_1_2_14_121_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-020-0333-7"},{"key":"e_1_2_14_122_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12318"},{"key":"e_1_2_14_123_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2020.105146"},{"key":"e_1_2_14_124_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13024-017-0199-3"},{"key":"e_1_2_14_125_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-010-0679-9"},{"key":"e_1_2_14_126_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40478-025-01935-y"},{"key":"e_1_2_14_127_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2015.01.001"},{"key":"e_1_2_14_128_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000010192"},{"key":"e_1_2_14_129_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13086"},{"key":"e_1_2_14_130_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.6.3.263"},{"key":"e_1_2_14_131_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(82)34663-1"},{"key":"e_1_2_14_132_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2024.102446"},{"key":"e_1_2_14_133_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneurpsyc.1948.02310050017002"},{"key":"e_1_2_14_134_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(26)90732-0"},{"key":"e_1_2_14_135_1","doi-asserted-by":"publisher","DOI":"10.4103\/jcor.jcor_120_24"},{"key":"e_1_2_14_136_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41531-023-00570-5"},{"key":"e_1_2_14_137_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1994.00540210060013"},{"key":"e_1_2_14_138_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.1129"},{"key":"e_1_2_14_139_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-023-02623-8"},{"key":"e_1_2_14_140_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0952523811000393"},{"key":"e_1_2_14_141_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0952523811000344"},{"key":"e_1_2_14_142_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.83.1.159"},{"key":"e_1_2_14_143_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40135-014-0048-2"},{"key":"e_1_2_14_144_1","doi-asserted-by":"publisher","DOI":"10.1023\/B:DOOP.0000019487.88486.0a"},{"key":"e_1_2_14_145_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2019.06.003"},{"key":"e_1_2_14_146_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2006.09.102"},{"key":"e_1_2_14_147_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.05-0301"},{"key":"e_1_2_14_148_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2017.04.001"},{"key":"e_1_2_14_149_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21910"},{"key":"e_1_2_14_150_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1902301116"},{"key":"e_1_2_14_151_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2017.07.006"},{"key":"e_1_2_14_152_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2018.06.3057"},{"key":"e_1_2_14_153_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnana.2022.945295"},{"key":"e_1_2_14_154_1","doi-asserted-by":"publisher","DOI":"10.1016\/0197-4580(96)00038-3"},{"key":"e_1_2_14_155_1","doi-asserted-by":"publisher","DOI":"10.1002\/ebm2.15"},{"key":"e_1_2_14_156_1","doi-asserted-by":"publisher","DOI":"10.1002\/trc2.12114"},{"key":"e_1_2_14_157_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.pmbts.2020.07.007"},{"key":"e_1_2_14_158_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1022318921994"},{"key":"e_1_2_14_159_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181c3f293"},{"key":"e_1_2_14_160_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31823efc6c"},{"key":"e_1_2_14_161_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhn113"},{"key":"e_1_2_14_162_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2009.215"},{"key":"e_1_2_14_163_1","first-page":"1779","article-title":"Direct Visualization and Mapping of the Spatial Course of Fiber Tracts at Microscopic Resolution in the Human Hippocampus","volume":"27","author":"Zeineh MM","year":"2017","journal-title":"Cereb Cortex"},{"key":"e_1_2_14_164_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-022-08838-9"},{"key":"e_1_2_14_165_1","article-title":"Structural magnetic resonance imaging for the early diagnosis of dementia due to Alzheimer's disease in people with mild cognitive impairment","volume":"3","author":"Lombardi G","year":"2020","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_14_166_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.24811"},{"key":"e_1_2_14_167_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-021-00837-0"},{"key":"e_1_2_14_168_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-132345"},{"key":"e_1_2_14_169_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2018.00642"},{"key":"e_1_2_14_170_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2018.01.014"},{"key":"e_1_2_14_171_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2020.00006"},{"key":"e_1_2_14_172_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-24304-3"},{"key":"e_1_2_14_173_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2017.03.010"},{"key":"e_1_2_14_174_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.25784"},{"key":"e_1_2_14_175_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.108.537704"},{"key":"e_1_2_14_176_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2017.01.026"},{"key":"e_1_2_14_177_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnen\/nlx009"},{"key":"e_1_2_14_178_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.26487"},{"key":"e_1_2_14_179_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000055927.22611.EB"},{"key":"e_1_2_14_180_1","doi-asserted-by":"publisher","DOI":"10.1053\/jscd.2003.5"},{"key":"e_1_2_14_181_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2020.116607"},{"key":"e_1_2_14_182_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-140588"},{"key":"e_1_2_14_183_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2013.01.009"},{"key":"e_1_2_14_184_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2003.12.027"},{"key":"e_1_2_14_185_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24320"},{"key":"e_1_2_14_186_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2019.109824"},{"key":"e_1_2_14_187_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.05.2351"},{"key":"e_1_2_14_188_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2021.5205"},{"key":"e_1_2_14_189_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2024.1326784"},{"key":"e_1_2_14_190_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000200947"},{"key":"e_1_2_14_191_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.76143"},{"key":"e_1_2_14_192_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000010017"},{"key":"e_1_2_14_193_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-141239"},{"key":"e_1_2_14_194_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2541090558"},{"key":"e_1_2_14_195_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43587-022-00204-0"},{"key":"e_1_2_14_196_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000004643"},{"key":"e_1_2_14_197_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2020.03.011"},{"key":"e_1_2_14_198_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.4668"},{"key":"e_1_2_14_199_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2019.101771"},{"key":"e_1_2_14_200_1","article-title":"(1)(8)F\u2010FDG PET for the early diagnosis of Alzheimer's disease dementia and other dementias in people with mild cognitive impairment (MCI)","volume":"1","author":"Smailagic N","year":"2015","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_14_201_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(21)00066-1"},{"key":"e_1_2_14_202_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2022.3157"},{"key":"e_1_2_14_203_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2019.2000"},{"key":"e_1_2_14_204_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2023.11703"},{"key":"e_1_2_14_205_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-024-01456-1"},{"key":"e_1_2_14_206_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines10071713"},{"key":"e_1_2_14_207_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2023.5319"},{"key":"e_1_2_14_208_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.14526"},{"key":"e_1_2_14_209_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.14573"},{"key":"e_1_2_14_210_1","doi-asserted-by":"publisher","DOI":"10.14283\/jpad.2024.110"},{"key":"e_1_2_14_211_1","doi-asserted-by":"publisher","DOI":"10.14283\/jpad.2021.70"},{"key":"e_1_2_14_212_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2021.3180"},{"key":"e_1_2_14_213_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-024-06804-3"},{"key":"e_1_2_14_214_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-231080"},{"key":"e_1_2_14_215_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000008081"},{"key":"e_1_2_14_216_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.12134"},{"key":"e_1_2_14_217_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awaa286"},{"key":"e_1_2_14_218_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13041-019-0448-1"},{"key":"e_1_2_14_219_1","article-title":"Plasma and cerebrospinal fluid amyloid beta for the diagnosis of Alzheimer's disease dementia and other dementias in people with mild cognitive impairment (MCI)","volume":"2014","author":"Ritchie C","year":"2014","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_14_220_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43587-025-00872-8"},{"key":"e_1_2_14_221_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-024-12674-w"},{"key":"e_1_2_14_222_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.87.7.899"},{"key":"e_1_2_14_223_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2016.05.013"},{"key":"e_1_2_14_224_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.61.5.44"},{"key":"e_1_2_14_225_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0952523811000216"},{"key":"e_1_2_14_226_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0134750"},{"key":"e_1_2_14_227_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dadm.2015.03.001"},{"key":"e_1_2_14_228_1","first-page":"263","article-title":"Meta\u2010analysis of the relationship of peripheral retinal nerve fiber layer thickness to Alzheimer's disease and mild cognitive impairment","volume":"27","author":"Wang M","year":"2015","journal-title":"Shanghai Arch Psychiatry"},{"key":"e_1_2_14_229_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2020.578698"},{"key":"e_1_2_14_230_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clineuro.2020.106036"},{"key":"e_1_2_14_231_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dadm.2016.07.004"},{"key":"e_1_2_14_232_1","doi-asserted-by":"publisher","DOI":"10.1111\/aos.14121"},{"key":"e_1_2_14_233_1","doi-asserted-by":"publisher","DOI":"10.1111\/aos.14640"},{"key":"e_1_2_14_234_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dadm.2016.09.001"},{"key":"e_1_2_14_235_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0192646"},{"key":"e_1_2_14_236_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-49353-0"},{"key":"e_1_2_14_237_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awac128"},{"key":"e_1_2_14_238_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-021-01348-z"},{"key":"e_1_2_14_239_1","doi-asserted-by":"publisher","DOI":"10.21873\/anticanres.14349"},{"key":"e_1_2_14_240_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40477-022-00755-3"},{"key":"e_1_2_14_241_1","doi-asserted-by":"publisher","DOI":"10.1167\/tvst.12.7.12"},{"key":"e_1_2_14_242_1","doi-asserted-by":"publisher","DOI":"10.1364\/BOE.8.002536"},{"key":"e_1_2_14_243_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.survophthal.2023.09.006"},{"key":"e_1_2_14_244_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-16638-0"},{"key":"e_1_2_14_245_1","first-page":"1263203","article-title":"Wide\u2010field computational cellular\u2010resolution imaging of the human retina using multi\u2010MHz phase\u2010stable SS\u2010OCT","volume":"12632","author":"Lee B","year":"2023","journal-title":"SPIE Conference Proceedings"},{"key":"e_1_2_14_246_1","doi-asserted-by":"publisher","DOI":"10.1109\/JLT.2021.3061606"},{"key":"e_1_2_14_247_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43586-021-00066-7"},{"key":"e_1_2_14_248_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-06419-2"},{"key":"e_1_2_14_249_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0266974"},{"key":"e_1_2_14_250_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-07638-x"},{"key":"e_1_2_14_251_1","doi-asserted-by":"publisher","DOI":"10.1002\/dad2.12071"},{"key":"e_1_2_14_252_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0255362"},{"key":"e_1_2_14_253_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2022.860759"},{"key":"e_1_2_14_254_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oret.2022.05.010"},{"key":"e_1_2_14_255_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.19-28137"},{"key":"e_1_2_14_256_1","doi-asserted-by":"publisher","DOI":"10.2147\/OPTH.S284872"},{"key":"e_1_2_14_257_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo-2022-321399"},{"key":"e_1_2_14_258_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oret.2019.02.002"},{"key":"e_1_2_14_259_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2022.993621"},{"key":"e_1_2_14_260_1","doi-asserted-by":"publisher","DOI":"10.1111\/aos.14419"},{"key":"e_1_2_14_261_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-37271-6"},{"key":"e_1_2_14_262_1","doi-asserted-by":"publisher","DOI":"10.1097\/WNO.0000000000001954"},{"key":"e_1_2_14_263_1","doi-asserted-by":"publisher","DOI":"10.1097\/WNO.0000000000001907"},{"key":"e_1_2_14_264_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcv2.12029"},{"key":"e_1_2_14_265_1","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2013.58"},{"key":"e_1_2_14_266_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2018.02.041"},{"key":"e_1_2_14_267_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-85010-1"},{"key":"e_1_2_14_268_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2021.0320"},{"key":"e_1_2_14_269_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41433-021-01614-x"},{"key":"e_1_2_14_270_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181e3966e"},{"key":"e_1_2_14_271_1","doi-asserted-by":"publisher","DOI":"10.1364\/OL.501851"},{"key":"e_1_2_14_272_1","doi-asserted-by":"publisher","DOI":"10.21037\/qims-20-1137"},{"key":"e_1_2_14_273_1","doi-asserted-by":"publisher","DOI":"10.1177\/1535370219897617"},{"key":"e_1_2_14_274_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aanat.2024.152239"},{"key":"e_1_2_14_275_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.28747"},{"key":"e_1_2_14_276_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.066873"},{"key":"e_1_2_14_277_1","doi-asserted-by":"publisher","DOI":"10.1097\/WNO.0000000000001786"},{"key":"e_1_2_14_278_1","doi-asserted-by":"publisher","DOI":"10.1002\/dad2.12347"},{"key":"e_1_2_14_279_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41433-019-0406-2"},{"key":"e_1_2_14_280_1","doi-asserted-by":"publisher","DOI":"10.1167\/tvst.9.9.2"},{"key":"e_1_2_14_281_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-022-03037-0"},{"key":"e_1_2_14_282_1","doi-asserted-by":"publisher","DOI":"10.1177\/10406387231204876"},{"key":"e_1_2_14_283_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-12242-1"},{"key":"e_1_2_14_284_1","doi-asserted-by":"publisher","DOI":"10.1167\/tvst.9.9.9"},{"key":"e_1_2_14_285_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trci.2019.09.006"},{"key":"e_1_2_14_286_1","doi-asserted-by":"publisher","DOI":"10.1093\/pnasnexus\/pgac164"},{"key":"e_1_2_14_287_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.93621"},{"key":"e_1_2_14_288_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-210327"},{"key":"e_1_2_14_289_1","doi-asserted-by":"publisher","DOI":"10.1002\/dad2.12109"},{"key":"e_1_2_14_290_1","doi-asserted-by":"publisher","DOI":"10.1002\/dad2.12199"},{"key":"e_1_2_14_291_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-017-0239-9"},{"key":"e_1_2_14_292_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2020.572337"},{"key":"e_1_2_14_293_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.11101975"},{"key":"e_1_2_14_294_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2018.4406"},{"key":"e_1_2_14_295_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2016.12.011"},{"key":"e_1_2_14_296_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2014.10.010"},{"key":"e_1_2_14_297_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dadm.2017.10.005"},{"key":"e_1_2_14_298_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dadm.2019.05.002"},{"key":"e_1_2_14_299_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2020.117213"},{"key":"e_1_2_14_300_1","doi-asserted-by":"publisher","DOI":"10.2147\/EB.S402510"},{"key":"e_1_2_14_301_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cortex.2013.02.001"},{"key":"e_1_2_14_302_1","doi-asserted-by":"publisher","DOI":"10.1515\/revneuro-2013-0025"},{"key":"e_1_2_14_303_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000183615.07936.b6"},{"key":"e_1_2_14_304_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2019.110792"},{"key":"e_1_2_14_305_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-024-01408-9"},{"key":"e_1_2_14_306_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2010.08.044"},{"key":"e_1_2_14_307_1","doi-asserted-by":"publisher","DOI":"10.1097\/WNO.0000000000001673"},{"key":"e_1_2_14_308_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12006"},{"key":"e_1_2_14_309_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedinformatics2030028"},{"key":"e_1_2_14_310_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awaa276"},{"key":"e_1_2_14_311_1","volume-title":"BEAM: Brain\u2010Eye Amyloid Memory Study (BEAM)","author":"Black SE","year":"2015"},{"key":"e_1_2_14_312_1","unstructured":"BesirliCG.Multimodal Ocular Imaging in Neurodegeneration. Updated Mar 28 2022ed2018."},{"key":"e_1_2_14_313_1","unstructured":"CognatE.Finding Retinal Biomarkers in Alzheimer's Disease (FIREBALZ). Updated Oct 12 2022ed2021."},{"key":"e_1_2_14_314_1","unstructured":"StalmansI.Multimodal Retinal Imaging in the Detection and Follow\u2010up of Alzheimer's Disease (RetAD). Updated Mar 15 2018ed2021."},{"key":"e_1_2_14_315_1","volume-title":"Atlas of Retinal Imaging in Alzheimer's Study (ARIAS)","author":"Alber J","year":"2019"},{"key":"e_1_2_14_316_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-023-01189-7"},{"key":"e_1_2_14_317_1","doi-asserted-by":"publisher","DOI":"10.4324\/9780203774441"},{"key":"e_1_2_14_318_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-022-00998-6"},{"key":"e_1_2_14_319_1","volume-title":"Cochrane Handbook for Systematic Reviews of Interventions Version 62","author":"Julian PT Higgins JPT","year":"2021"},{"key":"e_1_2_14_320_1","doi-asserted-by":"publisher","DOI":"10.1111\/cns.13963"},{"key":"e_1_2_14_321_1","doi-asserted-by":"publisher","DOI":"10.1093\/braincomms\/fcae472"},{"key":"e_1_2_14_322_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-024-01668-5"},{"key":"e_1_2_14_323_1","doi-asserted-by":"publisher","DOI":"10.1002\/dad2.12421"},{"key":"e_1_2_14_324_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12105"},{"key":"e_1_2_14_325_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.03.005"},{"key":"e_1_2_14_326_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.03.008"},{"key":"e_1_2_14_327_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-85801-6"},{"key":"e_1_2_14_328_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.legalmed.2021.101862"},{"key":"e_1_2_14_329_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics11030413"},{"key":"e_1_2_14_330_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.15-18856"},{"key":"e_1_2_14_331_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2010.06.025"},{"key":"e_1_2_14_332_1","doi-asserted-by":"publisher","DOI":"10.1017\/S104161021500037X"},{"key":"e_1_2_14_333_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-3768.1979.tb06662.x"},{"key":"e_1_2_14_334_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.17-23549"},{"key":"e_1_2_14_335_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12886-022-02289-y"},{"key":"e_1_2_14_336_1","doi-asserted-by":"publisher","DOI":"10.1093\/geroni\/igz036"},{"key":"e_1_2_14_337_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2012.00111"},{"key":"e_1_2_14_338_1","first-page":"410","volume-title":"Statistical power analysis for the behavioral sciences","author":"Cohen J","year":"1988"},{"key":"e_1_2_14_339_1","first-page":"316","volume-title":"Modern Methods for Business Research (ebook)","author":"Chin WW","year":"1998"},{"key":"e_1_2_14_340_1","doi-asserted-by":"publisher","DOI":"10.32614\/RJ-2020-013"},{"key":"e_1_2_14_341_1","volume-title":"Multi\u2010 and Megavariate Data Analysis Basic Principles and Applications","author":"Eriksson L","year":"2013"},{"key":"e_1_2_14_342_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-200043"},{"key":"e_1_2_14_343_1","doi-asserted-by":"publisher","DOI":"10.1111\/aos.14327"},{"key":"e_1_2_14_344_1","doi-asserted-by":"publisher","DOI":"10.1097\/IJG.0000000000000768"},{"key":"e_1_2_14_345_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2023.1281751"},{"key":"e_1_2_14_346_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2010.04.032"},{"key":"e_1_2_14_347_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2025.1529719"},{"key":"e_1_2_14_348_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2018-311874"},{"key":"e_1_2_14_349_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(24)02317-1"},{"key":"e_1_2_14_350_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2015-307223"},{"key":"e_1_2_14_351_1","doi-asserted-by":"publisher","DOI":"10.1017\/cjn.2016.415"},{"key":"e_1_2_14_352_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12632"},{"key":"e_1_2_14_353_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2018.1563"},{"key":"e_1_2_14_354_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2022-069258"},{"key":"e_1_2_14_355_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.63.9.28"},{"key":"e_1_2_14_356_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.70252"},{"key":"e_1_2_14_357_1","doi-asserted-by":"publisher","DOI":"10.1167\/tvst.13.2.16"},{"key":"e_1_2_14_358_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10792-023-02837-5"},{"key":"e_1_2_14_359_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2014.06.031"},{"key":"e_1_2_14_360_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.11-8209"},{"key":"e_1_2_14_361_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.107.497438"},{"key":"e_1_2_14_362_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2012.03785.x"},{"key":"e_1_2_14_363_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-015-1392-5"},{"key":"e_1_2_14_364_1","first-page":"313","volume-title":"Medical Physiology E\u2010Book. Saintt Louis","author":"Boron WF","year":"2016"}],"container-title":["Alzheimer's &amp; Dementia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alz.70884","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/alz.70884","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alz.70884","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T06:37:49Z","timestamp":1780123069000},"score":1,"resource":{"primary":{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/10.1002\/alz.70884"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":363,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["10.1002\/alz.70884"],"URL":"https:\/\/doi.org\/10.1002\/alz.70884","archive":["Portico"],"relation":{},"ISSN":["1552-5260","1552-5279"],"issn-type":[{"value":"1552-5260","type":"print"},{"value":"1552-5279","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"2025-06-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-07","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70884"}}