{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T07:03:06Z","timestamp":1780124586311,"version":"3.54.0"},"reference-count":43,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T00:00:00Z","timestamp":1762473600000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000957","name":"Alzheimer's Association","doi-asserted-by":"publisher","award":["SAGA23"],"award-info":[{"award-number":["SAGA23"]}],"id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000957","name":"Alzheimer's Association","doi-asserted-by":"publisher","award":["SAGA23\u20101141999"],"award-info":[{"award-number":["SAGA23\u20101141999"]}],"id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp; Dementia"],"published-print":{"date-parts":[[2025,11]]},"abstract":"Abstract<\/jats:title>\n \n \n Dementia rates are rising globally, with the burden increasing most rapidly in low\u2010 to middle\u2010income countries. Despite this, research into Alzheimer's disease and related dementias (ADRD) among African populations remains limited, with existing models based on Western cohorts that overlook sex\u2010, gender\u2010, and ancestry\u2010specific factors. The Female Brain Health and Endocrine Research in Africa (FemBER\u2010Africa) project, hosted at the Brain and Mind Institute, Aga Khan University, Kenya, will establish a deeply phenotyped cohort of 250 African individuals across the ADRD spectrum. It will assess sex\u2010specific risk factors linked to ethnicity, lifestyle, and endocrinological variables using fluid\u2010based biomarkers (blood and saliva), neuroimaging (magnetic resonance imaging and positron emission tomography), and culturally adapted cognitive tests. By comparing data with Western and diasporic cohorts, the study aims to identify ancestry\u2010specific and shared mechanisms driving ADRD risk and progression. The findings will support targeted, culturally relevant prevention and intervention strategies, addressing the underrepresentation of African populations in global dementia research.<\/jats:p>\n <\/jats:sec>\n \n Highlights<\/jats:title>\n \n \n \n By 2030, > 78 million individuals are expected to have dementia, with the highest burden among women in low\u2010 to middle\u2010income countries. Despite this, African populations remain underrepresented in Alzheimer's disease and related dementias (ADRD) research.<\/jats:p>\n <\/jats:list-item>\n \n Existing ADRD risk models fail to account for the unique influence of sex, gender, and ancestry on dementia risk. Female\u2010specific reproductive and hormonal factors, including menopause transition and hormone therapy use, are poorly integrated into current models.<\/jats:p>\n <\/jats:list-item>\n \n The Female Brain Health and Endocrine Research in Africa (FemBER\u2010Africa) project is the first large\u2010scale study to examine sex\u2010 or gender\u2010specific and endocrine contributors to ADRD in an African population, using advanced diagnostic, biomarker, and culturally adapted cognitive assessments.<\/jats:p>\n <\/jats:list-item>\n \n The study will assess how biological (hormonal, metabolic), lifestyle (physical activity, diet), and socio\u2010cultural (education, health\u2010care access) factors interact to influence ADRD risk in African women.<\/jats:p>\n <\/jats:list-item>\n \n Insights from FemBER\u2010Africa will inform the development of sex\u2010 and gender\u2010specific, culturally adapted ADRD prevention strategies, enhancing the precision and equity of dementia mitigation efforts globally.<\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/alz.70887","type":"journal-article","created":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T09:41:36Z","timestamp":1762508496000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Identifying sex\u2010 and gender\u2010specific endocrinological, lifestyle, psychosocial, and socio\u2010cultural targets for Alzheimer's disease prevention in Africans: The Female Brain Health and Endocrine Research in Africa (FemBER\u2010Africa) project"],"prefix":"10.1002","volume":"21","author":[{"given":"Chinedu T.","family":"Udeh\u2010Momoh","sequence":"first","affiliation":[{"name":"School of Public Health Sciences Wake Forest University School of Medicine Winston\u2010Salem North Carolina USA"},{"name":"Brain and Mind Institute Aga Khan University Nairobi Kenya"},{"name":"Division of Clinical Geriatrics Center for Alzheimer Research Karolinska Institutet Solna Sweden"},{"name":"Sheffield Institute for Translational Neuroscience (SITraN) The University of Sheffield Sheffield UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benard","family":"Aliwa","sequence":"additional","affiliation":[{"name":"Brain and Mind Institute Aga Khan University Nairobi Kenya"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lukoye","family":"Atwoli","sequence":"additional","affiliation":[{"name":"Brain and Mind Institute Aga Khan University Nairobi Kenya"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Blackmon","sequence":"additional","affiliation":[{"name":"Brain and Mind Institute Aga Khan University Nairobi Kenya"},{"name":"Geisel School of Medicine at Dartmouth Hanover New Hampshire USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edna","family":"Bosire","sequence":"additional","affiliation":[{"name":"Brain and Mind Institute 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