{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T18:57:16Z","timestamp":1792177036096,"version":"4.4.0"},"reference-count":59,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T00:00:00Z","timestamp":1762473600000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["GNT1171851"],"award-info":[{"award-number":["GNT1171851"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>This study aimed to identify distinct dementia risk profiles in middle\u2010aged adults with two or more potential dementia risk factors, to inform targeted prevention strategies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>Cross\u2010sectional analysis of baseline sociodemographic, clinical, and dementia\u2010risk data from the HAPPI MIND trial. Dementia risk was assessed using the Australian National University Alzheimer's Disease Risk Index. Risk profiles were identified using latent class analysis (LCA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Among 403 participants (mean age 56.4\u00a0\u00b1\u00a05.7 years, 62.5% female), the median number of dementia risk factors was 5.0; hyperlipidaemia (92.5%), low cognitive activity (72.5%), obesity (57.6%), and hypertension (52.7%) were the most prevalent. Several risk factors showed significant positive correlations. LCA identified three distinct classes:\n                      <jats:italic>1\u2212High Cardiometabolic Burden; 2\u2212High Behavioural and Psychosocial Risk<\/jats:italic>\n                      ; and\n                      <jats:italic>3\u2212Low Risk with Healthy Behaviours<\/jats:italic>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>The identified latent classes highlight heterogeneity of dementia risk profile in midlife. Tailored, multidomain interventions addressing each group's specific needs may improve dementia risk profiles and support broader health outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>Middle\u2010aged Australians who participated in the HAPPI MIND dementia risk reduction trial had a median of five modifiable risk factors.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Significant positive correlations were observed between behavioral and clinical risk factors, such as depression, along with poor diet, social isolation, and smoking.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>\n                            Latent class analysis revealed three distinct profiles:\n                            <jats:italic>High Cardiometabolic Burden; High Behavioral and Psychosocial Risk;<\/jats:italic>\n                            and\n                            <jats:italic>Low Risk with Healthy Behaviors<\/jats:italic>\n                            .\n                          <\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>The findings suggest there is a need for personalized, multidomain prevention strategies tailored to individual risk profiles in primary care.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.70888","type":"journal-article","created":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T09:45:59Z","timestamp":1762508759000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Identifying dementia risk profiles for targeted interventions: A latent class analysis of at\u2010risk middle\u2010aged Australians"],"prefix":"10.1002","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4312-9157","authenticated-orcid":false,"given":"Muhammad Rehan","family":"Sarwar","sequence":"first","affiliation":[{"name":"Centre for Medicine Use and Safety Faculty of Pharmacy and Pharmaceutical Sciences Monash University  Parkville Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda J.","family":"Cross","sequence":"additional","affiliation":[{"name":"Centre for Medicine Use and Safety Faculty of Pharmacy and Pharmaceutical Sciences Monash University  Parkville Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kali","family":"Godbee","sequence":"additional","affiliation":[{"name":"Centre for Medicine Use and Safety Faculty of Pharmacy and Pharmaceutical Sciences Monash University  Parkville Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gopisankar Mohanannair","family":"Geethadevi","sequence":"additional","affiliation":[{"name":"Centre for Medicine Use and Safety Faculty of Pharmacy and Pharmaceutical Sciences Monash University  Parkville Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parker","family":"Magin","sequence":"additional","affiliation":[{"name":"School of Medicine and Public Health The University of Newcastle  Newcastle New South Wales Australia"},{"name":"School of Population Health University of New South Wales  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"Tullipan","sequence":"additional","affiliation":[{"name":"Centre for Medicine Use and Safety Faculty of Pharmacy and Pharmaceutical Sciences Monash University  Parkville Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda L.","family":"Baker","sequence":"additional","affiliation":[{"name":"National Drug and Alcohol Research Centre University of New South Wales  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Billie","family":"Bonevski","sequence":"additional","affiliation":[{"name":"Flinders Health and Medical Research Institute Flinders University  Bedford Park South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie A.","family":"Ward","sequence":"additional","affiliation":[{"name":"Centre for Healthy Brain Ageing University of New South Wales  Sydney New South Wales Australia"},{"name":"School of Public Health and Preventive Medicine Faculty of Medicine Nursing and Health Sciences Monash University  St Kilda Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajay","family":"Mahal","sequence":"additional","affiliation":[{"name":"Nossal Institute for Global Health University of Melbourne  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Versace","sequence":"additional","affiliation":[{"name":"Deakin Rural Health Faculty of Health Deakin University  Warrnambool Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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