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Little is known about the causes of variance in p\u2010tau217 concentrations in cognitively unimpaired populations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      The present sample included cognitively healthy twins and their family members (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a06495). Biometric twin models were used to determine relative genetic and environmental contributions to variance in p\u2010tau217, and genetic and environmental correlations between p\u2010tau217 and neurofilament light chain (NfL), glial fibrillary acidic protein (GFAP), and amyloid beta 42\/40 (A\u03b242\/40).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Genetic contributions accounted for 42% (males) and 41% (females) of variance in p\u2010tau217. Half of the genetic effects were sex specific. Genetic and environmental contributions to p\u2010tau217 were partially shared with NfL, GFAP, and A\u03b242\/40, but different patterns were found in males and females.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>P\u2010tau217 concentrations are moderately heritable. Sex\u2010specific genetic influences are found to act on p\u2010tau217. In cognitively unimpaired participants, p\u2010tau217 and A\u03b242\/40 reflect different biological processes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>Phosphorylated tau (p\u2010tau)217 concentrations are substantially heritable (&gt;\u00a041%).<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Genetic contributions to variation in plasma p\u2010tau217 were found to be sex specific.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Genetic and environmental correlations were found between p\u2010tau217 and Alzheimer's disease biomarkers.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>P\u2010tau217 reflects different processes in cognitively unimpaired males and females.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.70906","type":"journal-article","created":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T15:49:32Z","timestamp":1763048972000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Genetic and environmental contributions to variation in plasma phosphorylated tau 217"],"prefix":"10.1002","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9355-7286","authenticated-orcid":false,"given":"Rebecca Z.","family":"Rousset","sequence":"first","affiliation":[{"name":"Neurochemistry Laboratory, Department of Clinical Chemistry, Amsterdam UMC Vrije Universiteit Amsterdam, Amsterdam Neuroscience  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Conor V.","family":"Dolan","sequence":"additional","affiliation":[{"name":"Department of Biological Psychology, Faculty of Behavioural and Movement Sciences Vrije Universiteit Amsterdam  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David H.","family":"Wilson","sequence":"additional","affiliation":[{"name":"Quanterix Corp  Billerica Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisanne","family":"in \u2018t Veld","sequence":"additional","affiliation":[{"name":"Neurochemistry Laboratory, Department of Clinical Chemistry, Amsterdam UMC Vrije Universiteit Amsterdam, Amsterdam Neuroscience  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lannie","family":"Ligthart","sequence":"additional","affiliation":[{"name":"Department of Biological Psychology, Faculty of Behavioural and Movement Sciences Vrije Universiteit Amsterdam  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte E.","family":"Teunissen","sequence":"additional","affiliation":[{"name":"Neurochemistry Laboratory, Department of Clinical Chemistry, Amsterdam UMC Vrije Universiteit Amsterdam, Amsterdam Neuroscience  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eco J. 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