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After adjusting for the severity of cognitive impairment, only the memory impairment cluster showed a higher risk of RCC. Baseline cognitive profiles did not predict different rates of cognitive decline, change in HR\u2010QoL, or caregiver burden.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>The memory impairment cluster showed a higher risk of developing a reliable cognitive change; however, baseline cognitive profiles did not consistently predict different rates of cognitive decline, HR\u2010QoL, or caregiver burden.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights:<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>Data\u2010driven approach to identify cognitive profiles.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Cognitive decline across domains assessed by risk of reliable cognitive change.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Cognitive profiles did not predict rate of cognitive decline.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Memory impairment profile had a higher risk of reliable cognitive change.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.70912","type":"journal-article","created":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T09:24:35Z","timestamp":1765617875000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cognitive profiles at presentation and subsequent cognitive decline and quality of life in Parkinson's disease"],"prefix":"10.1002","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0973-2246","authenticated-orcid":false,"given":"Saira S.","family":"Mirza","sequence":"first","affiliation":[{"name":"The Sandra Black Centre for Brain Resilience and Recovery Hurvitz Brain Sciences Research Program Sunnybrook Research Institute University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Duff\u2010Canning","sequence":"additional","affiliation":[{"name":"The Edmond J Safra Program in Parkinson's Disease and the Morton and Gloria Shulman Movement Disorders Centre Toronto Western Hospital University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Mapstone","sequence":"additional","affiliation":[{"name":"Department of Neurology The University of California  Irvine California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Fox","sequence":"additional","affiliation":[{"name":"The Edmond J Safra Program in Parkinson's Disease and the Morton and Gloria Shulman Movement Disorders Centre Toronto Western Hospital University of Toronto  Toronto Ontario Canada"},{"name":"Department of Medicine Division of Neurology University of Toronto  Toronto Ontario Canada"},{"name":"Krembil Research Institute University Health Network. 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