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The lower integrity of the LC\u2010EC pathway accompanying Alzheimer's disease (AD) pathology is supported by\n                      <jats:italic>post mortem<\/jats:italic>\n                      studies, but in vivo evidence remains limited.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>We associated diffusion\u2010weighted 7T magnetic resonance imaging (MRI) metrics of microstructural integrity within the LC\u2010EC tract to plasma AD\u2010related biomarkers in a cohort of 47 cognitively unimpaired adults.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Worse overall and local LC\u2010EC integrity, indicated by lower fractional anisotropy (FA) and higher mean diffusivity (MD), was related to elevated concentrations of plasma phosphorylated tau 181 (p\u2010tau181), p\u2010tau217, and glial fibrillary acidic protein (GFAP). A higher orientation dispersion index (ODI) within the LC\u2010EC tract was linked to elevated plasma p\u2010tau181 and p\u2010tau231 levels.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>The lower integrity of the LC\u2010EC pathway may serve as a key indicator of the earliest AD\u2010related pathophysiological processes to improve detection of at\u2010risk individuals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>Standard DTI model metrics in the LC\u2010 EC tract are linked to elevated plasma p\u2010tau and GFAP.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>A higher ODI in the voxels containing the LC\u2010EC tract is related to elevated plasma p\u2010tau.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>LC\u2010EC integrity links to AD\u2010related biomarkers show topographic specificity.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Lower LC\u2010EC integrity may be a key indicator of the earliest AD\u2010related pathology.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.70915","type":"journal-article","created":{"date-parts":[[2025,11,30]],"date-time":"2025-11-30T12:32:47Z","timestamp":1764505967000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Locus coeruleus\u2010entorhinal cortex tract integrity is linked to plasma tau and glial fibrillary acidic protein"],"prefix":"10.1002","volume":"21","author":[{"given":"Yuliya","family":"Patsyuk","sequence":"first","affiliation":[{"name":"Faculty of Health Medicine and Life Sciences Mental Health and Neuroscience Research Institute Alzheimer Centre Limburg Maastricht University  Maastricht Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maxime","family":"Van Egroo","sequence":"additional","affiliation":[{"name":"Faculty of Health Medicine and Life Sciences Mental Health and Neuroscience Research Institute Alzheimer Centre Limburg Maastricht University  Maastricht Netherlands"},{"name":"Athinoula A. 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