{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T16:28:40Z","timestamp":1784824120307,"version":"3.55.0"},"reference-count":122,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T00:00:00Z","timestamp":1765238400000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>There is an urgency to achieve equitable representation of Latinx\u2010Hispanic participants in Alzheimer's disease (AD) clinical trials. Valid instruments for these communities contribute to the generalizability of clinical trial outcomes. The aim of this study was to review articles reporting studies that conducted a thorough assessment of the validity and reliability of three gold\u2010standard cognitive measures with U.S. Latinx\u2010Hispanic communities. We reviewed validity\/reliability studies of the Clinical Dementia Rating (CDR), Alzheimer's Disease Assessment Scale\u2014Cognition (ADAS\u2010Cog), and Repeatable Battery of the Assessment of Neuropsychological Scales (RBANS) among U.S. Latinx\u2010Hispanic communities. Database searches included PubMed and PsycINFO. For the CDR, one study assessed validity and the other reliability. For the RBANS, one study evaluated the diagnostic accuracy, and another conducted an equating analysis. No studies addressed the validation\/reliability of ADAS\u2010Cog. Our literature review revealed limited studies examining the validity and reliability of the CDR, ADAS\u2010Cog, and RBANS in U.S. Latinx\u2010Hispanic communities.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>Various government entities are mandating increased enrollment of the Latinx\u2010Hispanic communities in AD clinical trials without considering the potential negative impact of study results when invalid COAs are used in underrepresented communities.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Our investigation demonstrates three gold\u2010standard COAs routinely used in AD clinical trials have mostly not been validated on the Latinx\u2010Hispanic communities residing in the United States.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>We recommend specific actions to support the development of valid clinical outcome measures for the Latinx\u2010Hispanic communities.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.70918","type":"journal-article","created":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T05:26:22Z","timestamp":1765344382000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Validity of gold\u2010standard clinical outcome assessments in U.S. Latinx\u2010Hispanic participants enrolled in Alzheimer's disease clinical trials: A literature review"],"prefix":"10.1002","volume":"21","author":[{"given":"Lorena H.","family":"Monserratt","sequence":"first","affiliation":[{"name":"The Katherine and Benjamin Kagan Alzheimer's Disease Treatment Development Program University of California Los Angeles  Los Angeles California USA"},{"name":"Mary S. 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