{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T00:25:58Z","timestamp":1793060758483,"version":"4.5.0"},"reference-count":33,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T00:00:00Z","timestamp":1763683200000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100006312","name":"BrightFocus Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006312","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>Apolipoprotein E allele 4 (APOE \u03b54) is the main genetic risk factor for late\u2010onset Alzheimer's disease (AD), but most evidence comes from White populations in high\u2010income countries. We investigated APOE and AD pathology in an ethnically diverse Brazilian autopsy cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>This cross\u2010sectional study used Biobank for Aging Studies (BAS) data. AD pathology was evaluated with Braak, Consortium to Establish a Registry for Alzheimer's Disease, and Thal criteria. APOE genotypes were obtained from blood or brain tissue. Regression models were adjusted for age, sex, race, and education; interaction with race was tested.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Among 1391 participants (mean age 75.1\u00a0\u00b1\u00a012.4 years, 50% women, 64% White), APOE \u03b54showed a dose response with greater AD pathological burden and higher odds of AD diagnosis, while APOE \u03b52\/X was protective. APOE \u03b54\/\u03b54 did not show full penetrance across age groups. Associations were similar in White and Black individuals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>APOE \u03b54was strongly associated with AD pathology, with consistent associations across racial groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>APOE \u03b54 increased AD neuropathological burden in Brazilians.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>APOE \u03b52\/\u03b5X was protective against AD pathology.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>APOE \u03b54\/\u03b54did not show full penetrance across age groups.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Associations between APOE and AD pathology were similar by race.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Large multiethnic autopsy study expands evidence beyond high\u2010income country studies.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.70927","type":"journal-article","created":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T11:30:09Z","timestamp":1763724609000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Apolipoprotein E and Alzheimer's disease pathology in a diverse autopsy study"],"prefix":"10.1002","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5942-4778","authenticated-orcid":false,"given":"Claudia K.","family":"Suemoto","sequence":"first","affiliation":[{"name":"Division of Geriatrics Faculdade de Medicina Universidade de Sao Paulo  Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Regina","family":"Paradela","sequence":"additional","affiliation":[{"name":"Division of Geriatrics Faculdade de Medicina Universidade de Sao Paulo  Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renata E. P.","family":"Leite","sequence":"additional","affiliation":[{"name":"Division of Geriatrics Faculdade de Medicina Universidade de Sao Paulo  Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vitor R.","family":"Paes","sequence":"additional","affiliation":[{"name":"Department of Pathology Faculdade de Medicina Universidade de Sao Paulo  Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos A.","family":"Pasqualucci","sequence":"additional","affiliation":[{"name":"Department of Pathology Faculdade de Medicina Universidade de Sao Paulo  Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Ferriolli","sequence":"additional","affiliation":[{"name":"Division of Geriatrics Faculdade de Medicina Universidade de Sao Paulo  Sao Paulo 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