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We examined domain\u2010specific associations of subjective sleep with cognition, brain networks, and AD biomarkers in non\u2010demented older adults.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      We studied 849 non\u2010demented participants from the Chinese Preclinical Alzheimer's Disease Study (CPAS) cohort. Subjective sleep dimensions were assessed, along with cognition, resting\u2010state functional magnetic resonance imaging, [\n                      <jats:sup>18<\/jats:sup>\n                      F]\u2010florbetapir positron emission tomography, and plasma AD biomarkers. Associations were examined using adjusted general linear models\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Most sleep characteristics worsened across the cognitive continuum except for duration. Sleep quality, efficiency, and daytime dysfunction were linked to poorer cognition, altered networks, and higher A\u03b2\/tau levels. In contrast, sleep duration and disturbances showed paradoxical associations with plasma biomarkers. Use of sleep medication was related to better cognition and memory.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Adequacy\u2010 and function\u2010related sleep dimensions aligned with AD\u2010related decline, whereas quantity\u2010 and fragmentation\u2010related dimensions reflected network changes or subjective\u2013objective discrepancies, suggesting distinct biological underpinnings of different sleep problems.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>Different subjective sleep dimensions show distinct links with cognition and AD biomarkers.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Sleep quality, efficiency, and daytime dysfunction relate to cognition, networks, and A\u03b2\/tau.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Shorter sleep and greater fragmentation show paradoxical associations with plasma biomarkers.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Sleep alterations may involve heterogeneous biological pathways in the AD continuum.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Multidimensional sleep assessment may improve early detection and risk stratification in AD.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  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