{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T07:03:07Z","timestamp":1780124587204,"version":"3.54.0"},"reference-count":64,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T00:00:00Z","timestamp":1764201600000},"content-version":"vor","delay-in-days":26,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 AG067501"],"award-info":[{"award-number":["R01 AG067501"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 AG072474"],"award-info":[{"award-number":["R01 AG072474"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["RF1 AG066107"],"award-info":[{"award-number":["RF1 AG066107"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL1TR001873"],"award-info":[{"award-number":["UL1TR001873"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01 AG054047"],"award-info":[{"award-number":["R01 AG054047"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["RF1 AG054047"],"award-info":[{"award-number":["RF1 AG054047"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01AG027161"],"award-info":[{"award-number":["R01AG027161"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["P30 AG062715"],"award-info":[{"award-number":["P30 AG062715"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp; Dementia"],"published-print":{"date-parts":[[2025,11]]},"abstract":"Abstract<\/jats:title>\n \n INTRODUCTION<\/jats:title>\n \n Core 1 biomarkers, such as amyloid positron emission tomography, capture the earliest biological changes leading to Alzheimer's disease (AD). While\n APOE<\/jats:italic>\n is a major genetic factor, the contribution of other variants to Core 1 biomarkers remains unclear. The goal of this study was to determine whether genetic regulators of Core 1 biomarker levels predicted AD pathology better than genetic regulators of clinical AD.\n <\/jats:p>\n <\/jats:sec>\n \n METHODS<\/jats:title>\n Among 955 non\u2010Hispanic White individuals, polygenic scores (PGSs) were built using genome\u2010wide association studies (GWASs) of amyloid PET, plasma tau phosphorylated at threonine 181 (p\u2010tau181), cerebrospinal fluid (CSF) p\u2010tau181, and clinical AD. Hispanic\u2010specific PGSs were constructed in 515 individuals using plasma p\u2010tau181 and clinical AD GWASs. Baseline and longitudinal associations with plasma biomarkers and cognition were assessed, and replication was conducted in separate cohorts.<\/jats:p>\n <\/jats:sec>\n \n RESULTS<\/jats:title>\n The Core 1 biomarker PGSs predicted AD pathology and associated cognitive performance better than the AD PGSs in both populations.<\/jats:p>\n <\/jats:sec>\n \n DISCUSSION<\/jats:title>\n The Core 1 PGSs show improved predictive value for AD\u2010related plasma biomarkers and early cognitive changes.<\/jats:p>\n <\/jats:sec>\n \n Highlights<\/jats:title>\n \n \n \n \n APOE<\/jats:italic>\n \u03b54 explained more variance in plasma p\u2010tau217 than in plasma p\u2010tau181.\n <\/jats:p>\n <\/jats:list-item>\n \n PGSs based on Core 1 biomarkers outperformed AD PGSs in predicting plasma biomarkers and cognitive decline among asymptomatic individuals in non\u2010Hispanic White and Hispanic individuals. However, the improvement in predictive power was modest and may vary by age.<\/jats:p>\n <\/jats:list-item>\n \n While the variance in p\u2010tau181 and p\u2010tau217 explained by individual Core 1 PGSs remains limited, the distinct genetic signals captured by the best\u2010performing PGSs across different Core 1 biomarkers may provide an opportunity for developing an integrative Core 1 PGS that more effectively predicts plasma p\u2010tau181 and p\u2010tau217 levels than AD\u2010based PGS.<\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/alz.70937","type":"journal-article","created":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T09:51:59Z","timestamp":1764237119000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Polygenic scores of Core 1 Alzheimer's disease biomarkers predict early cognitive and pathological change"],"prefix":"10.1002","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2732-7199","authenticated-orcid":false,"given":"Yuexuan","family":"Xu","sequence":"first","affiliation":[{"name":"Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Vagelos College of Physicians and Surgeons Columbia University New York New York USA"},{"name":"G.H. Sergievsky Center Vagelos College of Physicians and Surgeons Columbia University New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Qiao","sequence":"additional","affiliation":[{"name":"Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Vagelos College of Physicians and Surgeons Columbia University New York New York USA"},{"name":"G.H. Sergievsky Center Vagelos College of Physicians and Surgeons Columbia University New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamil I.","family":"Gunasekaran","sequence":"additional","affiliation":[{"name":"Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Vagelos College of Physicians and Surgeons Columbia University New York New York USA"},{"name":"G.H. Sergievsky Center Vagelos College of Physicians and Surgeons Columbia University New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yian","family":"Gu","sequence":"additional","affiliation":[{"name":"Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Vagelos College of Physicians and Surgeons Columbia University New York New York USA"},{"name":"G.H. Sergievsky Center Vagelos College of Physicians and Surgeons Columbia University New York New York USA"},{"name":"Department of Neurology, Vagelos College of Physicians and Surgeons Columbia University, and the New York Presbyterian Hospital New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dolly","family":"Reyes\u2010Dumeyer","sequence":"additional","affiliation":[{"name":"Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Vagelos College of Physicians and Surgeons Columbia University New York New York USA"},{"name":"G.H. Sergievsky Center Vagelos College of Physicians and Surgeons Columbia University New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angel","family":"Piriz","sequence":"additional","affiliation":[{"name":"Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Vagelos College of Physicians and Surgeons Columbia University New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danurys","family":"Sanchez","sequence":"additional","affiliation":[{"name":"Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Vagelos College of Physicians and Surgeons Columbia University New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Belisa","family":"Soriano","sequence":"additional","affiliation":[{"name":"Universidad Pedro Henr\u00edquez Urena Santo Domingo Dominican Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yahaira","family":"Franco","sequence":"additional","affiliation":[{"name":"Clinica Corominas Santiago Dominican Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zoraida Dominguez","family":"Coronado","sequence":"additional","affiliation":[{"name":"Cl\u00ednica Gregorio Hernandez Puerto Plata Dominican Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Recio","sequence":"additional","affiliation":[{"name":"CEDIMAT Santo Domingo Dominican Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diones Rivera","family":"Mejia","sequence":"additional","affiliation":[{"name":"Universidad Pedro Henr\u00edquez Urena Santo Domingo Dominican Republic"},{"name":"CEDIMAT Santo Domingo Dominican Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Medrano","sequence":"additional","affiliation":[{"name":"Pontificia Universidad Catolica Madre y Maestra (PUCMM) Santiago Dominican Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael A.","family":"Lantigua","sequence":"additional","affiliation":[{"name":"Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Vagelos College of Physicians and Surgeons Columbia University New York New York USA"},{"name":"Department of Medicine, Vagelos College of Physicians and Surgeons Columbia University, and the New York Presbyterian Hospital New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence","family":"Honig","sequence":"additional","affiliation":[{"name":"Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Vagelos College of Physicians and Surgeons Columbia University New York New York USA"},{"name":"G.H. Sergievsky Center Vagelos College of Physicians and Surgeons Columbia University New York New York USA"},{"name":"Department of Neurology, Vagelos College of Physicians and Surgeons Columbia University, and the New York Presbyterian Hospital New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachael","family":"Wilson","sequence":"additional","affiliation":[{"name":"Department of Medicine School of Medicine and Public Health University of Wisconsin\u2010Madison Madison Wisconsin USA"},{"name":"Wisconsin Alzheimer's Institute, School of Medicine and Public Health University of Wisconsin\u2010Madison Madison Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer J.","family":"Manly","sequence":"additional","affiliation":[{"name":"Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Vagelos College of Physicians and Surgeons Columbia University New York New York USA"},{"name":"G.H. Sergievsky Center Vagelos College of Physicians and Surgeons Columbia University New York New York USA"},{"name":"Department of Neurology, Vagelos College of Physicians and Surgeons Columbia University, and the New York Presbyterian Hospital New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam M.","family":"Brickman","sequence":"additional","affiliation":[{"name":"Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Vagelos College of Physicians and Surgeons Columbia University New York New York USA"},{"name":"G.H. Sergievsky Center Vagelos College of Physicians and Surgeons Columbia University New York New York USA"},{"name":"Department of Neurology, Vagelos College of Physicians and Surgeons Columbia University, and the New York Presbyterian Hospital New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corinne D.","family":"Engelman","sequence":"additional","affiliation":[{"name":"Department of Population Health Sciences, School of Medicine and Public Health University of Wisconsin\u2010Madison Madison Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sterling","family":"Johnson","sequence":"additional","affiliation":[{"name":"Department of Medicine School of Medicine and Public Health University of Wisconsin\u2010Madison Madison Wisconsin USA"},{"name":"Wisconsin Alzheimer's Institute, School of Medicine and Public Health University of Wisconsin\u2010Madison Madison Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjay","family":"Asthana","sequence":"additional","affiliation":[{"name":"Department of Medicine School of Medicine and Public Health University of Wisconsin\u2010Madison Madison Wisconsin USA"},{"name":"Wisconsin Alzheimer's Institute, School of Medicine and Public Health University of Wisconsin\u2010Madison Madison Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Badri","family":"Vardarajan","sequence":"additional","affiliation":[{"name":"Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Vagelos College of Physicians and Surgeons Columbia University New York New York USA"},{"name":"G.H. Sergievsky Center Vagelos College of Physicians and Surgeons Columbia University New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Mayeux","sequence":"additional","affiliation":[{"name":"Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Vagelos College of Physicians and Surgeons Columbia University New York New York USA"},{"name":"G.H. Sergievsky Center Vagelos College of Physicians and Surgeons Columbia University New York New York USA"},{"name":"Department of Neurology, Vagelos College of Physicians and Surgeons Columbia University, and the New York Presbyterian Hospital New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,27]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13859"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474\u20104422(20)30412\u20109"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010021\u201024082\u2010z"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/braincomms\/fcz047"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195\u2010020\u201000754\u20108"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195\u2010023\u201001277\u20108"},{"key":"e_1_2_8_8_1","doi-asserted-by":"crossref","unstructured":"SaariTT PalviainenT HiltunenM et\u00a0al.Cross\u2010sectional study of plasma phosphorylated Tau 217 in persons without dementia2024:2024.05.17.24307528. doi:10.1101\/2024.05.17.24307528","DOI":"10.1002\/dad2.70107"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD\u2010160195"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000200544"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2021.04.018"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40478\u2010023\u201001563\u20104"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s10038\u2010022\u201001026\u2010z"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401\u2010022\u201002454\u2010z"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2020.1760"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401\u2010017\u20101685\u2010y"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dadm.2017.11.007"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/trc2.70036"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2018.08.005"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13652"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2013.5570"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.14100"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12570"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2018.01.010"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2016.6117"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474\u20104422(20)30071\u20105"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12990"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12383"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13515"},{"key":"e_1_2_8_30_1","doi-asserted-by":"crossref","unstructured":"GunasekaranTI MeenaD LeeAJ et\u00a0al.Genome\u2010wide scan of Flortaucipir PET levels finds JARID2 associated with cerebral tau deposition. medRxiv 2024:2024.10.04.24314853. doi:10.1101\/2024.10.04.24314853","DOI":"10.1101\/2024.10.04.24314853"},{"key":"e_1_2_8_31_1","doi-asserted-by":"crossref","unstructured":"XuY QiaoM GunasekaranTI et\u00a0al.Identifying Individuals at High Risk for Alzheimer's Disease Among Hispanics Using Single and Multi\u2010Ancestry Polygenic Risk Scores2024:2024.10.21.24315877. doi:10.1101\/2024.10.21.24315877","DOI":"10.1101\/2024.10.21.24315877"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13742\u2010015\u20100047\u20108"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1086\/519795"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2015.11.022"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/gepi.21896"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btq559"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0191240"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13311\u2010023\u201001370\u20108"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588\u2010022\u201001024\u2010z"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/acn3.51757"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010024\u201045135\u2010z"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2013.06.020"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588\u2010019\u20100358\u20102"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2023.5319"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky780"},{"key":"e_1_2_8_46_1","doi-asserted-by":"crossref","unstructured":"LohZ ClarkS van derWerfJHJ.Effects of Experimental Design Genetic Architecture and Threshold on Power and False Positive Rate of Genome\u2010Wide Association Studies2022:2022.02.19.481168. doi:10.1101\/2022.02.19.481168","DOI":"10.1101\/2022.02.19.481168"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1093\/gigascience\/giz082"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1086\/522036"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1093\/braincomms\/fcad229"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195\u2010023\u201001298\u20103"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lana.2025.101198"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471\u20102105\u201014\u2010128"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2023.8214"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awac333"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1097\/NEN.0b013e31824b211b"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.21203\/rs.3.rs\u20106597595\/v1"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2014.4821"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000012775"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2025.1734"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.14060"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2014.2476"},{"key":"e_1_2_8_62_1","doi-asserted-by":"crossref","unstructured":"MooreAM FilshteinTJ DumitrescuL et\u00a0al.A\/T\/N polygenic risk score for cognitive decline in old age.2019. doi:10.1101\/838847","DOI":"10.1101\/838847"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.056252"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awab223"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010019\u201013848\u20101"}],"container-title":["Alzheimer's & Dementia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alz.70937","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/alz.70937","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alz.70937","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T06:39:24Z","timestamp":1780123164000},"score":1,"resource":{"primary":{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/10.1002\/alz.70937"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":64,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["10.1002\/alz.70937"],"URL":"https:\/\/doi.org\/10.1002\/alz.70937","archive":["Portico"],"relation":{},"ISSN":["1552-5260","1552-5279"],"issn-type":[{"value":"1552-5260","type":"print"},{"value":"1552-5279","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"2025-07-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-25","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70937"}}