{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T17:01:58Z","timestamp":1791478918120,"version":"4.3.4"},"reference-count":43,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T00:00:00Z","timestamp":1763942400000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100006465","name":"Korea Creative Content Agency","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006465","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002648","name":"Catholic University of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002648","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>Blood\u2010based biomarkers offer scalable, non\u2010invasive tools for Alzheimer's disease (AD) detection. We investigated the performance of plasma biomarkers associated with AD on the automated Beckman Coulter Access DxI 9000 analyzer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      This cross\u2010sectional study included 262 individuals from across the AD continuum. Plasma phosphorylated tau at threonine 217 (p\u2010tau217), amyloid beta (A\u03b2)42, and their ratio were measured. Diagnostic accuracy for amyloid positron emission tomography (PET) positivity (Centiloid\u00a0&gt;\u00a020), using a dual cutoff approach, was assessed via receiver operative characteristic curve. Associations with tau PET (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a076) were also assessed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>The p\u2010tau217\/A\u03b242 ratio showed the highest diagnostic accuracy for amyloid PET positivity (area under curve\u00a0=\u00a00.943) and the smallest indeterminate zone (8.0%). It correlated strongly and consistently with tau PET across Braak stages and with AD\u2010related cortical atrophy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>The p\u2010tau217\/A\u03b242 ratio was the most reliable plasma biomarker, closely tracking tau PET. It has potentials for clinical use in diagnosis and treatment monitoring.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>This is the first validation of the Beckman Coulter plasma immunoassay.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>The plasma phosphorylated tau at threonine 217 amyloid beta 42 ratio showed the highest accuracy across the full Alzheimer's disease (AD) spectrum.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Plasma biomarkers correlated with tau positron emission tomography and AD\u2010related brain atrophy.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Glial fibrillary acidic protein offered complementary value reflecting astrocytic activation.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.70942","type":"journal-article","created":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T07:52:35Z","timestamp":1764057155000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Neuroimaging correlates and biomarker performance of a fully automated plasma p\u2010tau217\/A\u03b242 ratio assay in a clinical cohort with Alzheimer's disease"],"prefix":"10.1002","volume":"21","author":[{"given":"Yoo Hyun","family":"Um","sequence":"first","affiliation":[{"name":"Department of Psychiatry St. Vincent's Hospital, College of Medicine The Catholic University of Korea  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Wynveen","sequence":"additional","affiliation":[{"name":"Beckman Coulter Inc. Research &amp; Development  Chaska Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Holland","sequence":"additional","affiliation":[{"name":"Beckman Coulter Inc. Biostatistics  Chaska Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kinal","family":"Bhatt","sequence":"additional","affiliation":[{"name":"Beckman Coulter Inc. Medical &amp; Science Affairs  Chaska Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zivjena","family":"Vucetic","sequence":"additional","affiliation":[{"name":"Beckman Coulter Inc. Medical &amp; Science Affairs  Chaska Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Engel","sequence":"additional","affiliation":[{"name":"Beckman Coulter Inc. Research &amp; Development  Chaska Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corey","family":"Carlson","sequence":"additional","affiliation":[{"name":"Beckman Coulter Inc. Research &amp; Development  Chaska Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Becker","sequence":"additional","affiliation":[{"name":"Beckman Coulter Inc. Biostatistics  Chaska Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene B.","family":"Meier","sequence":"additional","affiliation":[{"name":"Davos Alzheimer's Collaborative  Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vaibhav A.","family":"Narayan","sequence":"additional","affiliation":[{"name":"Davos Alzheimer's Collaborative  Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng\u2010Min","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Yeouido St. Mary's Hospital College of Medicine The Catholic University of Korea  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong Woo","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Seoul St. Mary's Hospital College of Medicine The Catholic University of Korea  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunghwan","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Yeouido St. Mary's Hospital College of Medicine The Catholic University of Korea  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suhyung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Psychiatry St. Vincent's Hospital, College of Medicine The Catholic University of Korea  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donghyeon","family":"Kim","sequence":"additional","affiliation":[{"name":"Research Institute Neurophet Inc.  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