{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T06:00:52Z","timestamp":1791525652199,"version":"4.3.4"},"reference-count":45,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T00:00:00Z","timestamp":1768262400000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["223082\/Z\/21\/Z"],"award-info":[{"award-number":["223082\/Z\/21\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>Cognitive impairments are a hallmark of Huntington's disease (HD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>Seventy\u2010one participants (43 HD gene\u2010expanded [HDGE], 28 healthy controls) from the HD\u2010Young Adult Study at two timepoints \u2248 4.7 years apart, completed the Cambridge Neuropsychological Test Automated Battery Rapid Visual Information Processing task and underwent resting\u2010state functional magnetic resonance imaging. We focused on predefined regions of interest that are involved in sustained attention.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      HDGE individuals showed significantly poorer sustained attention than controls (\n                      <jats:italic>\n                        p\n                        <jats:sub>adj<\/jats:sub>\n                      <\/jats:italic>\n                      \u00a0=\u00a00.007), with no significant change over time. Functional connectivity (FC) analyses revealed group differences in attention\u2010related networks, including the occipital\u2013operculum and lentiform\u2013orbitalis pathways. Time and group\u00a0\u00d7\u00a0time effects were also observed in frontal and parietal regions.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>These findings demonstrate early and persistent attention deficits in HDGE, linked to altered FC in attention\u2010related circuits. This supports the presence of early cognitive dysfunction in HD and highlights potential compensatory and pathological changes in brain networks prior to the onset of clinical motor symptoms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>We detail the discovery of early sustained attention deficits in Huntington's disease (HD) gene\u2010expanded (HDGE) young adults.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>These sustained attention deficits do not measurably decline over a 4.7\u2010year period.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Altered functional connectivity was observed in attention\u2010related brain networks.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Alterations in regions include occipital, opercular, lentiform, and frontal areas.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Findings support attention as an early cognitive biomarker in HDGE young adults.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.70944","type":"journal-article","created":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T12:59:10Z","timestamp":1768309150000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Discovery of disrupted sustained attention and altered functional connectivity in far\u2010from\u2010onset Huntington's disease gene\u2010expanded young adults"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5061-2820","authenticated-orcid":false,"given":"Christelle","family":"Langley","sequence":"first","affiliation":[{"name":"Department of Psychiatry University of Cambridge  Cambridge UK"},{"name":"Behavioural and Clinical Neuroscience Institute University of Cambridge  Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michela","family":"Leocadi","sequence":"additional","affiliation":[{"name":"Huntington's Disease Centre, Department of Neurodegenerative Disease UCL Queen Square Institute of Neurology University College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola Z.","family":"Hobbs","sequence":"additional","affiliation":[{"name":"Huntington's Disease Centre, Department of Neurodegenerative Disease UCL Queen Square Institute of Neurology University 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