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AD pathology was\u00a0determined by baseline amyloid beta\u00a0(A\u03b2) and tau positron emission tomography. Kaplan\u2010Meier survival analysis and Cox proportional hazards models evaluated MCI\u2010to\u2010AD progression. Linear mixed models\u00a0analyzed longitudinal cognitive\u00a0trajectories, amyloid accumulation, and cortical thickness.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>SSRI treatment showed no significant effect on AD\u00a0dementia progression (hazard ratio =\u00a01.64, 95% confidence interval: 0.61 to 4.38) or cognitive trajectories, regardless\u00a0of AD pathology. No significant differences\u00a0in\u00a0A\u03b2 accumulation or cortical\u00a0thickness were\u00a0observed between SSRI users and non\u2010users. External validation confirmed no significant\u00a0SSRI effect on AD progression\u00a0or cognitive decline.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>SSRI treatment was not associated with long\u2010term cognitive effects in amnestic MCI, irrespective of underlying AD pathology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>SSRI treatment was not associated with long\u2010term AD dementia risk in MCI.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>SSRI treatment had no impact\u00a0on long\u2010term cognitive performance changes in MCI.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>SSRI treatment did not affect A\u03b2 accumulation\u00a0or cortical thickness in MCI.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>SSRIs had no effect on MCI progression, regardless of underlying AD pathology.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.70946","type":"journal-article","created":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T09:18:42Z","timestamp":1764148722000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Effect of SSRIs on clinical progression in amnestic mild cognitive impairment stratified by Alzheimer's disease pathology"],"prefix":"10.1002","volume":"21","author":[{"given":"Yan","family":"Li","sequence":"first","affiliation":[{"name":"The National Clinical Research Center for Mental Disorders &amp; Beijing Key Laboratory of Mental Disorders Beijing Anding Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenying","family":"Liu","sequence":"additional","affiliation":[{"name":"Innovation Center for Neurological Disorders and Department of Neurology Xuanwu Hospital, Capital Medical University, National Clinical Research Center for Geriatric Diseases  Beijing P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuechu","family":"Wang","sequence":"additional","affiliation":[{"name":"The National Clinical Research Center for Mental Disorders &amp; Beijing Key Laboratory of Mental Disorders Beijing Anding Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Qin","sequence":"additional","affiliation":[{"name":"Innovation Center for Neurological Disorders and Department of Neurology Xuanwu Hospital, Capital Medical University, National Clinical Research Center for Geriatric Diseases  Beijing P.R. China"},{"name":"Beijing Key Laboratory of Geriatric Cognitive Disorders  Beijing P.R. China"},{"name":"Clinical Center for Neurodegenerative Disease and Memory Impairment Capital Medical University  Beijing P.R. 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