{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T04:01:34Z","timestamp":1780286494146,"version":"3.54.0"},"reference-count":22,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T00:00:00Z","timestamp":1765411200000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30 AG010133"],"award-info":[{"award-number":["P30 AG010133"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30 AG072976"],"award-info":[{"award-number":["P30 AG072976"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 AG081951"],"award-info":[{"award-number":["R01 AG081951"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 LM012535"],"award-info":[{"award-number":["R01 LM012535"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U01 AG072177"],"award-info":[{"award-number":["U01 AG072177"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U19 AG074879"],"award-info":[{"award-number":["U19 AG074879"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000957","name":"Alzheimer's Association","doi-asserted-by":"publisher","award":["AACSFD\u201024\u20101310485"],"award-info":[{"award-number":["AACSFD\u201024\u20101310485"]}],"id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>Cerebral amyloid angiopathy (CAA) and Alzheimer's disease (AD) both involve amyloid beta (A\u03b2) accumulation in vessels and brain parenchyma, respectively. As A\u03b2\u2010targeting therapies emerge, CAA draws attention due to its link with amyloid\u2010related imaging abnormalities (ARIA), underscoring the need for biomarkers beyond magnetic resonance imaging (MRI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>CAA polygenic risk scores (CAA\u2010PRS) were generated in 105 ADNI participants, and their predictive ability for pathological CAA was evaluated, including in subgroups with high amyloid burden or without MRI\u2010visible CAA markers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      CAA\u2010PRS was significantly associated with pathological CAA (OR\u00a0=\u00a01.766,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001), with an AUC of 0.783 overall and 0.766 (OR\u00a0=\u00a01.780,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.002) in those with high amyloid burden. A marginal association was observed in MRI\u2010negative individuals.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>CAA\u2010PRS may serve as a complementary biomarker to imaging for identifying high\u2010risk individuals with CAA, particularly in the context of A\u03b2\u2010targeting therapies and ARIA risk.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>CAA\u2010PRS is generated.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>CAA\u2010PRS is associated with pathologically confirmed CAA.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>CAA\u2010PRS is associated with CAA in individuals with high amyloid burden.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.70958","type":"journal-article","created":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T06:59:02Z","timestamp":1765522742000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Polygenic risk score predicts pathologically confirmed cerebral amyloid angiopathy"],"prefix":"10.1002","volume":"21","author":[{"given":"Jung\u2010Min","family":"Pyun","sequence":"first","affiliation":[{"name":"Department of Neurology Seoul National University Bundang Hospital and Seoul National University College of Medicine  Seongnam\u2010si Gyeonggi\u2010do Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Ho","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Neurology Seoul National University Bundang Hospital and Seoul National University College of Medicine  Seongnam\u2010si Gyeonggi\u2010do Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SangYun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neurology Seoul National University Bundang Hospital and Seoul National University College of Medicine  Seongnam\u2010si Gyeonggi\u2010do Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwangsik","family":"Nho","sequence":"additional","affiliation":[{"name":"Department of Radiology and Imaging Sciences and the Indiana Alzheimer's Disease Research Center Indiana University School of Medicine  Indianapolis Indiana USA"},{"name":"Center for Computational Biology and Bioinformatics Indiana University School of Medicine Health Information and Translational Science Building  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the Alzheimer's Disease Neuroimaging 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