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Digital cognitive assessments (DCAs) offer a promising solution by addressing longstanding barriers to routine cognitive testing and diagnosis. However, variations in performance and intended use have created confusion about their clinical applications and utility. The Global CEO Initiative on Alzheimer's Disease convened a DCA Workgroup to define the preferred characteristics of DCAs to meet the needs of patients, health care providers, and regulators for three clinical contexts: (1) initial detection of cognitive impairment, (2) diagnostic support for MCI and dementia, and (3) characterization of cognitive profiles to support identifying etiology. In the near term, ensuring that DCAs meet or exceed the performance of non\u2010digital tools is a priority. DCAs must be validated in the intended use population with well\u2010characterized study samples and inclusive designs.<\/jats:p>","DOI":"10.1002\/alz.70966","type":"journal-article","created":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T14:52:21Z","timestamp":1765983141000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Acceptable standards for clinic\u2010based digital cognitive assessments: Recommendations from the Global CEO Initiative on Alzheimer's Disease"],"prefix":"10.1002","volume":"21","author":[{"given":"Louisa I.","family":"Thompson","sequence":"first","affiliation":[{"name":"Department of Psychiatry &amp; Human Behavior Department of Family Medicine Brown University, Alpert Medical School  Providence Rhode Island USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barak","family":"Gaster","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Washington  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dustin B.","family":"Hammers","sequence":"additional","affiliation":[{"name":"Department of Neurology Indiana University School of Medicine  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sol","family":"Fittipaldi","sequence":"additional","affiliation":[{"name":"Latin American Brain Health Institute (BrainLat) Universidad Adolfo Ib\u00e1\u00f1ez  Santiago Chile"},{"name":"Global Brain Health Institute (GBHI) Trinity College Dublin  Dublin Ireland"},{"name":"Centro de Neurociencias Cognitivas Universidad de San Andr\u00e9s  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. 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