{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T00:42:12Z","timestamp":1790296932206,"version":"4.1.0"},"reference-count":84,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T00:00:00Z","timestamp":1766102400000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100017518","name":"Hans und Ilse Breuer-Stiftung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100017518","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006312","name":"BrightFocus Foundation","doi-asserted-by":"publisher","award":["A2021031S"],"award-info":[{"award-number":["A2021031S"]}],"id":[{"id":"10.13039\/100006312","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001826","name":"ZonMw","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp; Dementia"],"published-print":{"date-parts":[[2025,12]]},"abstract":"Abstract<\/jats:title>\n \n INTRODUCTION<\/jats:title>\n Whether Alzheimer's disease (AD)\u2010associated plasma biomarkers reflect cognitive performance and neuropathology in the oldest old remains unclear.<\/jats:p>\n <\/jats:sec>\n \n METHODS<\/jats:title>\n \n In plasma samples from 255 centenarians from the longitudinal 100\u2010plus Study (median age 101.2 years), we quantified biomarkers amyloid beta (A\u03b2)42\/40 ratio, A\u03b240, A\u03b242, phosphorylated tau 181 (pTau\u2010181)\/A\u03b242 ratio, pTau\u2010181, neurofilament light (NfL), and glial fibrillary acidic protein (GFAP) concentrations. These were associated with same\u2010day measures of cognitive performance and, for centenarians who donated their brain (\n n<\/jats:italic>\n \u00a0=\u00a060), with\n post mortem<\/jats:italic>\n A\u03b2 and tau neuropathology.\n <\/jats:p>\n <\/jats:sec>\n \n RESULTS<\/jats:title>\n Cognition ranged from high to early cognitive decline (median Mini\u2010Mental State Examination [MMSE] score\u00a0=\u00a026). Lower plasma A\u03b240 and A\u03b242 are associated with poorer executive functioning, attention\/processing speed, and higher A\u03b2 neuropathology. Elevated plasma NfL and GFAP are associated with poorer executive functioning, slower processing speed, and A\u03b2 and tau neuropathology. Higher plasma pTau\u2010181 and the pTau\u2010181\/A\u03b242 ratio are\u00a0associated with A\u03b2 and tau neuropathology, but not with cognitive performance. The A\u03b242\/40 ratio was uninformative.<\/jats:p>\n <\/jats:sec>\n \n DISCUSSION<\/jats:title>\n Plasma A\u03b2, NfL, and GFAP detected neuropathology and early cognitive decline in centenarians; plasma pTau\u2010181 and the pTau\u2010181\/A\u03b242 ratio\u00a0primarily report more advanced neuropathology.<\/jats:p>\n <\/jats:sec>\n \n Highlights<\/jats:title>\n \n \n \n Lower plasma A\u03b240 and A\u03b242 concentrations are associated with poorer executive functioning and higher A\u03b2 neuropathology, and thus may detect early cognitive decline in centenarians.<\/jats:p>\n <\/jats:list-item>\n \n Higher plasma pTau\u2010181 concentrations and the pTau\u2010181\/A\u03b242 ratio are strongly associated with A\u03b2 and tau neuropathology; however, they are not associated with cognitive performance.<\/jats:p>\n <\/jats:list-item>\n \n Higher NfL concentrations are associated with higher A\u03b2 and tau neuropathology.<\/jats:p>\n <\/jats:list-item>\n \n Higher plasma NfL and GFAP concentrations are associated with poorer attention and processing speed and may detect early cognitive decline in centenarians.<\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/alz.70969","type":"journal-article","created":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T11:42:47Z","timestamp":1766144567000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["AD\u2010related plasma biomarkers in centenarians: links to cognition and neuropathology"],"prefix":"10.1002","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-5206-4766","authenticated-orcid":false,"given":"Linda M. 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