{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T14:24:07Z","timestamp":1786112647344,"version":"build-2736575974"},"reference-count":73,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T00:00:00Z","timestamp":1767916800000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100005416","name":"Norges Forskningsr\u00e5d","doi-asserted-by":"publisher","award":["#344121"],"award-info":[{"award-number":["#344121"]}],"id":[{"id":"10.13039\/501100005416","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005416","name":"Norges Forskningsr\u00e5d","doi-asserted-by":"publisher","award":["#353629"],"award-info":[{"award-number":["#353629"]}],"id":[{"id":"10.13039\/501100005416","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005416","name":"Norges Forskningsr\u00e5d","doi-asserted-by":"publisher","award":["#327312"],"award-info":[{"award-number":["#327312"]}],"id":[{"id":"10.13039\/501100005416","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010661","name":"Horizon 2020 Framework Programme","doi-asserted-by":"publisher","award":["RCN 311993"],"award-info":[{"award-number":["RCN 311993"]}],"id":[{"id":"10.13039\/100010661","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007137","name":"Helse Nord RHF","doi-asserted-by":"publisher","award":["HNF1540\u201020"],"award-info":[{"award-number":["HNF1540\u201020"]}],"id":[{"id":"10.13039\/501100007137","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007137","name":"Helse Nord RHF","doi-asserted-by":"publisher","award":["HNF1569\u201021"],"award-info":[{"award-number":["HNF1569\u201021"]}],"id":[{"id":"10.13039\/501100007137","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013263","name":"Nasjonalforeningen for Folkehelsen","doi-asserted-by":"publisher","award":["22731"],"award-info":[{"award-number":["22731"]}],"id":[{"id":"10.13039\/501100013263","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013263","name":"Nasjonalforeningen for Folkehelsen","doi-asserted-by":"publisher","award":["25598"],"award-info":[{"award-number":["25598"]}],"id":[{"id":"10.13039\/501100013263","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>Alzheimer's disease (AD) is a neurodegenerative disorder influenced by genetic factors, particularly related to immune activation. This study examines genotype\u2010phenotype interactions affecting immune responses in AD as a reaction to neurodegeneration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      We computed AD polygenic risk scores (PRSs) informed by shared AD\u2010autoimmunity genetics (AD PRS\n                      <jats:sub>INFL<\/jats:sub>\n                      ), AD\u2010independent immune activation score from 10 autoimmune diseases (sum PRS\n                      <jats:sub>IMMUNE<\/jats:sub>\n                      ), and standard AD PRSs for 294 individuals. Cerebrospinal fluid (CSF) immune markers (sTREM2, clusterin, fractalkine, and chitinase 3 like protein (YKL\u201040)) were regressed on PRSs, and their interaction with neurodegeneration markers (total tau [t\u2010tau] or neurofilament light chain [NfL]).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      High AD PRS\n                      <jats:sub>INFL<\/jats:sub>\n                      scores correlated with lower sTREM2 (\n                      <jats:italic>\u03b2\u00a0<\/jats:italic>\n                      =\u00a0\u22120.18,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.01), clusterin (\n                      <jats:italic>\u03b2\u00a0<\/jats:italic>\n                      =\u00a0\u22120.12,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.05), and fractalkine (\n                      <jats:italic>\u03b2\u00a0<\/jats:italic>\n                      =\u00a0\u22120.13,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.05) levels in cases with elevated t\u2010tau. High sum PRS\n                      <jats:sub>IMMUNE<\/jats:sub>\n                      score correlated with lower clusterin in cases with elevated NfL (\n                      <jats:italic>\u03b2\u00a0<\/jats:italic>\n                      =\u00a0\u22120.12,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Genetic predisposition for immune activation might cause unfavorable immune response in early AD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>High genetic risk relates to cerebrospinal fluid (CSF) immune markers amid evident neurodegeneration<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Immune polygenic risk scores (PRSs) capture genotype\u2010phenotype associations in Alzheimer's disease (AD) immune activation<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>AD PRSs and immune phenotype had an opposite relationship of the phenotype PRSs<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Importance of specific genetic predispositions in early AD immune phenotypes<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.70978","type":"journal-article","created":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T07:54:47Z","timestamp":1768031687000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Genotype\u2013phenotype interaction in Alzheimer's disease immune activation"],"prefix":"10.1002","volume":"22","author":[{"given":"Stephanie","family":"Knudtzon","sequence":"first","affiliation":[{"name":"Department of Neurology University Hospital of North Norway  Troms\u00f8 Norway"},{"name":"Department of Psychology Faculty of Health Sciences UiT The Arctic University of Norway  Troms\u00f8 Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bj\u00f8rn\u2010Eivind","family":"Kirsebom","sequence":"additional","affiliation":[{"name":"Department of Neurology University Hospital of North Norway  Troms\u00f8 Norway"},{"name":"Department of Psychology Faculty of Health Sciences UiT The Arctic University of Norway  Troms\u00f8 Norway"},{"name":"Department of Neurology Akershus University Hospital, Lorenskog  L\u00f8renskog Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lene","family":"P\u00e5lhaugen","sequence":"additional","affiliation":[{"name":"Department of Neurology Akershus University Hospital, Lorenskog  L\u00f8renskog Norway"},{"name":"Institute of Clinical Medicine University of Oslo  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Bettella","sequence":"additional","affiliation":[{"name":"Section for Precision Psychiatry Department of Psychiatry Oslo University Hospital  Oslo Norway"},{"name":"Department of Medical Genetics Oslo University Hospital Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berglind","family":"G\u00edslad\u00f3ttir","sequence":"additional","affiliation":[{"name":"Department of Neurology Akershus University Hospital, Lorenskog  L\u00f8renskog Norway"},{"name":"Clinical Molecular Biology (EpiGen) Medical Division Akershus University Hospital and University of Oslo  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shahram","family":"Bahrami","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medicine University of Oslo  Oslo Norway"},{"name":"Section for Precision Psychiatry Department of Psychiatry Oslo University Hospital  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lavinia","family":"Athanasiu","sequence":"additional","affiliation":[{"name":"Section for Precision Psychiatry Department of Psychiatry Oslo University Hospital  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arvid","family":"Rongve","sequence":"additional","affiliation":[{"name":"Department of Research and Innovation Haugesund Hospital  Haugesund Norway"},{"name":"Institute of Clinical Medicine (K1) University of Bergen  Bergen Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arne","family":"Nakling","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medicine (K1) University of Bergen  Bergen Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ina S.","family":"Almdahl","sequence":"additional","affiliation":[{"name":"Department of Neurology Akershus University Hospital, Lorenskog  L\u00f8renskog Norway"},{"name":"Institute of Clinical Medicine University of Oslo  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Kalheim","sequence":"additional","affiliation":[{"name":"Department of Neurology Akershus University Hospital, Lorenskog  L\u00f8renskog Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonas Alexander","family":"Jarholm","sequence":"additional","affiliation":[{"name":"Department of Neurology Akershus University Hospital, Lorenskog  L\u00f8renskog Norway"},{"name":"Institute of Clinical Medicine University of Oslo  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00f8ril Rolfseng","family":"Gr\u00f8ntvedt","sequence":"additional","affiliation":[{"name":"Department of Neurology and Clinical Neurophysiology University Hospital of Trondheim  Trondheim Norway"},{"name":"Department of Neuromedicine and Movement Science Faculty of Medicine and Health Sciences Norwegian University of Science and Technology  Trondheim Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ragnhild Eide","family":"Skogseth","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medicine (K1) University of Bergen  Bergen Norway"},{"name":"Department of Geriatric Medicine and the Neuro\u2010SysMed Centre Haraldsplass Deaconess Hospital  Bergen Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dag","family":"Aarsland","sequence":"additional","affiliation":[{"name":"Department of Old Age Psychiatry Institute of Psychiatry, Psychology and Neuroscience King's College London  London UK"},{"name":"Center for Age\u2010Related Diseases Stavanger University Hospital  Stavanger Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Knut","family":"Waterloo","sequence":"additional","affiliation":[{"name":"Department of Neurology University Hospital of North Norway  Troms\u00f8 Norway"},{"name":"Department of Psychology Faculty of Health Sciences UiT The Arctic University of Norway  Troms\u00f8 Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ole A.","family":"Andreassen","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medicine University of Oslo  Oslo Norway"},{"name":"Section for Precision Psychiatry Department of Psychiatry Oslo University Hospital  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tormod","family":"Fladby","sequence":"additional","affiliation":[{"name":"Department of Neurology Akershus University Hospital, Lorenskog  L\u00f8renskog Norway"},{"name":"Institute of Clinical Medicine University of Oslo  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5897-6394","authenticated-orcid":false,"given":"Kaja","family":"Nordengen","sequence":"additional","affiliation":[{"name":"Department of Neurology Akershus University Hospital, Lorenskog  L\u00f8renskog Norway"},{"name":"Institute of Clinical Medicine University of Oslo  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,9]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13016"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2023.104511"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-019-0358-2"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2802"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2014.05.041"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awv268"},{"issue":"1","key":"e_1_2_11_8_1","article-title":"Phenotype\u2010informed polygenic risk scores are associated with worse outcome in individuals at risk of Alzheimer's disease","volume":"14","author":"Nordengen K","year":"2022","journal-title":"Alzheimers Dement"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2017.08.013"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000002922"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/dds491"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0079771"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2021.650220"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.120.16471"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-020-0800-0"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2014.05.1757"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(15)70016-5"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-023-02973-w"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13024-018-0301-5"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12239"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-170231"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2014.01.001"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.03.008"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2024.05.016"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.201809712"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-99794-9"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature08185"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-018-0311-9"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3359"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature12873"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.543"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2012.02.020"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature10251"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2616"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3434"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2272"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2667"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-019-02060-2"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.381"},{"key":"e_1_2_11_40_1","volume-title":"R: A Language and Environment for Statistical Computing","author":"Team RC","year":"2022"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2023.12.005"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-020-01018-7"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.26891"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2310168"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.202012921"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000008081"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.12.056"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-47286-5"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2017.00008"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20041611"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI77983"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1211851"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddu277"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2021.834697"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.201506123"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-019-1399-2"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.201606540"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-018-0058-z"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-016-0182-1"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-012-8237-1"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004010050815"},{"key":"e_1_2_11_62_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-160889"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11011-018-0325-0"},{"key":"e_1_2_11_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/1357-2725(95)00027-M"},{"key":"e_1_2_11_65_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0128029"},{"key":"e_1_2_11_66_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0103351"},{"key":"e_1_2_11_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-5728(01)00259-4"},{"key":"e_1_2_11_68_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2009.06253.x"},{"key":"e_1_2_11_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(03)02867-1"},{"key":"e_1_2_11_70_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3639.2011.00550.x"},{"key":"e_1_2_11_71_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13024-017-0226-4"},{"key":"e_1_2_11_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2010.08.025"},{"key":"e_1_2_11_73_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aax3519"},{"key":"e_1_2_11_74_1","doi-asserted-by":"publisher","DOI":"10.1093\/braincomms\/fcz047"}],"container-title":["Alzheimer's &amp; Dementia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alz.70978","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/alz.70978","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alz.70978","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T15:28:55Z","timestamp":1785943735000},"score":1,"resource":{"primary":{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/10.1002\/alz.70978"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":73,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1002\/alz.70978"],"URL":"https:\/\/doi.org\/10.1002\/alz.70978","archive":["Portico"],"relation":{},"ISSN":["1552-5260","1552-5279"],"issn-type":[{"value":"1552-5260","type":"print"},{"value":"1552-5279","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2025-04-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70978"}}