{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T10:52:55Z","timestamp":1782298375179,"version":"3.54.5"},"reference-count":41,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T00:00:00Z","timestamp":1765843200000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>Functional\u00a0impairment\u00a0across degenerative dementias\u00a0remains understudied in Latin American contexts. We aimed to\u00a0assess total and item\u2010level functional performance,\u00a0determine specific instrumental activities,\u00a0and\u00a0identify differences in functional profiles between groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>In this cross\u2010sectional study, 1445 participants were classified\u00a0according to the\u00a0Pfeffer Functional Activities Questionnaire (PFAQ). Statistical comparisons were adjusted for age, sex, and education using linear regression residuals and corrected for multiple comparisons.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Functional impairment increased progressively from normal cognition to dementia. Alzheimer's disease (AD) and frontotemporal dementia (FTD) groups showed significantly greater total PFAQ scores compared to controls and mild cognitive impairment (MCI). Distinct profiles of impairment emerged: AD was more associated with memory\u2010dependent tasks, while FTD showed disproportionate deficits in executive and social activities.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Functional abilities are differentially impacted in AD and FTD within the Peruvian population. Our findings highlight the importance of item\u2010level functional evaluation to support early detection and subtype differentiation of dementia in underserved regions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>HIGHLIGHTS<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>We characterized and compared functional abilities among Peruvian older adults with normal cognition and neurodegenerative disease in different stages.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>PFAQ scores were analyzed across dementia stages in a Peruvian population.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Functional abilities were differentially impacted in Peruvian participants with AD compared to FTD.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>AD was more associated with memory\u2010dependent tasks, while FTD showed disproportional deficits in executive and social activities.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.70979","type":"journal-article","created":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T10:28:36Z","timestamp":1765880916000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Functional capacity in Peruvian people with Alzheimer's disease and frontotemporal dementia"],"prefix":"10.1002","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8025-3272","authenticated-orcid":false,"given":"Nilton","family":"Custodio","sequence":"first","affiliation":[{"name":"Instituto Peruano de Neurociencias Unidad de diagn\u00f3stico de deterioro cognitivo y prevenci\u00f3n de demencia  Lince Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory","family":"Brown","sequence":"additional","affiliation":[{"name":"Instituto Peruano de Neurociencias Unidad de diagn\u00f3stico de deterioro cognitivo y prevenci\u00f3n de demencia  Lince Peru"},{"name":"Department of Neurology University of California  San Francisco California USA"},{"name":"Department of Internal Medicine Medstar Washington Hospital Center  Washington District of Columbia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bel\u00e9n","family":"Custodio","sequence":"additional","affiliation":[{"name":"Instituto Peruano de Neurociencias Unidad de diagn\u00f3stico de deterioro cognitivo y prevenci\u00f3n de demencia  Lince Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa","family":"Montesinos","sequence":"additional","affiliation":[{"name":"Instituto Peruano de Neurociencias Unidad de diagn\u00f3stico de deterioro cognitivo y prevenci\u00f3n de demencia  Lince Peru"},{"name":"Centro de Investigaci\u00f3n del Envejecimiento, Facultad de Medicina Universidad de San Mart\u00edn de Porres  La Molina Peru"},{"name":"Equilibria Unidad de Investigaci\u00f3n y Docencia Santiago de Surco Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milagros","family":"Nu\u00f1ez\u2010Huanca","sequence":"additional","affiliation":[{"name":"Instituto Peruano de Neurociencias Unidad de diagn\u00f3stico de deterioro cognitivo y prevenci\u00f3n de demencia  Lince Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela","family":"Bartolo","sequence":"additional","affiliation":[{"name":"Instituto Peruano de Neurociencias Unidad de diagn\u00f3stico de deterioro cognitivo y prevenci\u00f3n de demencia  Lince Peru"},{"name":"Equilibria Unidad de Investigaci\u00f3n y Docencia Santiago de Surco Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zadith","family":"Yauri","sequence":"additional","affiliation":[{"name":"Instituto Peruano de Neurociencias Unidad de diagn\u00f3stico de deterioro cognitivo y prevenci\u00f3n de demencia  Lince Peru"},{"name":"Equilibria Unidad de Investigaci\u00f3n y Docencia Santiago de Surco Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine","family":"Ag\u00fcero","sequence":"additional","affiliation":[{"name":"Instituto Peruano de Neurociencias Unidad de diagn\u00f3stico de deterioro cognitivo y prevenci\u00f3n de demencia  Lince Peru"},{"name":"Equilibria Unidad de Investigaci\u00f3n y Docencia Santiago de Surco Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graciet","family":"Verastegui","sequence":"additional","affiliation":[{"name":"Instituto Peruano de Neurociencias Unidad de diagn\u00f3stico de deterioro cognitivo y prevenci\u00f3n de demencia  Lince Peru"},{"name":"Equilibria Unidad de Investigaci\u00f3n y Docencia Santiago de Surco Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agustin","family":"Iba\u00f1ez","sequence":"additional","affiliation":[{"name":"Latin American Brain Health Institute (BrainLat) Universidad Adolfo Iba\u00f1ez  Santiago de Chile Chile"},{"name":"Cognitive Neuroscience Center Universidad de San Andres  Buenos Aires Argentina"},{"name":"Global Brain Health Institute (GBHI) Trinity College Dublin  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,16]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1041610209009430"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2022.101703"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2017.00221"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10072\u2010024\u201007366\u20102"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD\u2010230376"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12877\u2010024\u201005381\u20108"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/15333175221104354"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1590\/1980\u201057642020dn14\u2010020006"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/gps.5531"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.15381\/anales.v69i4.1110"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2023.1228008"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2014.181"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.03.008"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.03.005"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awr179"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.4067\/S0034\u201098872009000500009"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0221717"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1041610204000043"},{"issue":"132","key":"e_1_2_10_20_1","first-page":"467","article-title":"Validaci\u00f3n de un test de tamizaje para el diagn\u00f3stico de demencia asociada a edad, en Chile (Validation of a screening test for age associated cognitive impairment, in Chile)","author":"Quiroga P","year":"2004","journal-title":"Rev M\u00e9d Chile"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.140.6.566"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.15381\/anales.v75i1.6951"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.17843\/rpmesp.2016.334.2549"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1177\/1533317519869709"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2020.00374"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2005.53221.x"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195\u2010020\u201000706\u20102"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1177\/07067437221147443"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1212\/CPJ.0000000000000264"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/dad2.70028"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1177\/0891988720901791"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/dad2.12452"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glx235"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12889\u2010025\u201022788\u2010z"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.14335"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1159\/000539335"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12916\u2010024\u201003492\u2010y"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000200781"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lana.2022.100387"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181e04070"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12877\u2010022\u201003476\u20108"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2025.1535146"}],"container-title":["Alzheimer's &amp; Dementia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alz.70979","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/alz.70979","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alz.70979","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T03:41:09Z","timestamp":1780285269000},"score":1,"resource":{"primary":{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/10.1002\/alz.70979"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":41,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10.1002\/alz.70979"],"URL":"https:\/\/doi.org\/10.1002\/alz.70979","archive":["Portico"],"relation":{},"ISSN":["1552-5260","1552-5279"],"issn-type":[{"value":"1552-5260","type":"print"},{"value":"1552-5279","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"2025-08-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-31","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70979"}}