{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T17:16:31Z","timestamp":1790270191033,"version":"4.1.0"},"reference-count":41,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T00:00:00Z","timestamp":1768435200000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp; Dementia"],"published-print":{"date-parts":[[2026,1]]},"abstract":"Abstract<\/jats:title>\n \n INTRODUCTION<\/jats:title>\n Alzheimer's disease (AD) is a major public health concern in Korea, with a high prevalence among older adults. A community\u2010based longitudinal study is essential for tracking disease progression, identifying biomarkers, and developing targeted prevention and treatment strategies. The Gwangju Alzheimer's & Related Dementias (GARD) cohort was established to address these needs through a multimodal approach.<\/jats:p>\n <\/jats:sec>\n \n METHODS<\/jats:title>\n Participants aged \u226560 years undergo comprehensive clinical evaluations, neuroimaging, and biospecimen collection for multi\u2010omics analyses (genomics, transcriptomics, proteomics, and metagenomics) at baseline and systematic follow\u2010up visits.<\/jats:p>\n <\/jats:sec>\n \n RESULTS<\/jats:title>\n \n From over 17,000 screened individuals, 12,877 were enrolled. Baseline diagnoses include 5,123 cognitively unimpaired (CU), 3,250 mild cognitive impairment (MCI), and 2,125 AD dementia. The resource includes magnetic resonance imaging scans (\n n\u00a0<\/jats:italic>\n =\u00a010,843) and extensive multi\u2010omics data: genomic (\n n\u00a0<\/jats:italic>\n =\u00a010,775), proteomic (\n n\u00a0<\/jats:italic>\n =\u00a0116), and microbiome (\n n\u00a0<\/jats:italic>\n =\u00a0595).\n <\/jats:p>\n <\/jats:sec>\n \n DISCUSSION<\/jats:title>\n The integrated GARD dataset provides a powerful and scalable resource for identifying novel biomarkers, understanding disease heterogeneity, and advancing precision medicine for AD.<\/jats:p>\n <\/jats:sec>\n \n Highlights<\/jats:title>\n \n \n \n Gwangju Alzheimer's & Related Dementias (GARD) is a large\u2010scale, longitudinal, community\u2010based cohort study in South Korea.<\/jats:p>\n <\/jats:list-item>\n \n The study focuses on early detection and monitoring of dementia progression.<\/jats:p>\n <\/jats:list-item>\n \n GARD includes cognitive testing, imaging, biospecimens, and multi\u2010omics data.<\/jats:p>\n <\/jats:list-item>\n \n We aim to identify Korean\u2010specific biomarkers predictive of cognitive decline.<\/jats:p>\n <\/jats:list-item>\n \n Supports East Asian insights and fills gaps in global Alzheimer's research.<\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/alz.70981","type":"journal-article","created":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T12:00:51Z","timestamp":1768478451000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The Gwangju Alzheimer's & Related Dementias (GARD) cohort: Over a decade of Asia's largest longitudinal multimodal study"],"prefix":"10.1002","volume":"22","author":[{"given":"Kyu Yeong","family":"Choi","sequence":"first","affiliation":[{"name":"Gwangju Alzheimer's and Related Dementia Cohort Research Center Chosun University Gwangju Republic of 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